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Diagnostic Pathology

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Open Access 01-12-2015 | Case Report

Malignant perivascular epithelioid cell tumor (PEComa) of the femur: a case report and literature review

Authors: I Weng Lao, Lin Yu, Jian Wang

Published in: Diagnostic Pathology | Issue 1/2015

Abstract

Background

We describe a case of malignant perivascular epithelial cell tumor (PEComa) arising primarily in the distal left femur of a 47-year-old male.

Case presentation

The patient presented with pain accompanied by progressive swelling of his left thigh. Computed tomography (CT) scan and magnetic resonance imaging (MRI) revealed an osteolytic lesion. Curettage of the lesion was reported as a clear cell tumor with recommendation for exclusion of a metastatic clear cell carcinoma. However, thorough examinations did not find any primary site elsewhere, apart from the presence of bilateral pulmonary metastases. Evaluation of the submitted H & E slides identified a malignant PEComa which was further confirmed by subsequent immunohistochemical study.

Conclusions

The occurrence of PEComa as a primary bone lesion is extremely rare. We present here a malignant PEComa of the distal left femur, and summarize the clinicopathological characteristics of this rare entity with literature review.

Virtual slides

The virtual slide (s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/5729035221600545.

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Title: Malignant perivascular epithelioid cell tumor (PEComa) of the femur: a case report and literature review
Authors: I Weng Lao
Lin Yu
Jian Wang
Publication date: 01-12-2015
Publisher: BioMed Central
Published in: Diagnostic Pathology / Issue 1/2015
Electronic ISSN: 1746-1596
DOI: https://doi.org/10.1186/s13000-015-0292-2

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Springer Medicine

Malignant perivascular epithelioid cell tumor (PEComa) of the femur: a case report and literature review

Abstract

Background

Case presentation

Conclusions

Virtual slides

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Case presentation

Conclusions

Virtual slides

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