Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Diagnostic Pathology
Published in: Diagnostic Pathology 1/2014

Open Access 01-12-2014 | Research

Genetic susceptibility to total hip arthroplasty failure: a case-control study on the influence of MMP 1 gene polymorphism

Authors: Yiguo Yan, Jianzhong Hu, Hongbin Lu, Wenjun Wang

Published in: Diagnostic Pathology | Issue 1/2014

Login to get access

Abstract

Background

Genetic factors plays an important role in early failure of total hip arthroplasty (THA) etiology and MMP-1 gene polymorphism rs5854 may be involved. The present study was conducted to reveal the possible association between MMP-1 rs5854 C/T polymorphism and the risk of early failure of THA (aseptic loosening).

Methods

The rs5854 single nucleotide polymorphism (SNP) in MMP-1 gene was genotyped in 63 subjects who were diagnosed as aseptic loosening after total hip arthroplasty within 10 years and in 81 age and gender matched controls.

Results

The genotype frequencies of the MMP-1 rs5854 C/T polymorphism were 57.1% (CC), 28.6% (CT), and 14.3% (TT) in patients with failure of THA, and 79.0% (CC), 17.3% (CT), and 3.7% (TT) in the controls (P = 0.0099). Rs5854 polymorphism was found to be significantly associated with increased risk of aseptic loosening.

Conclusion

The results showed the rs5854 SNP was associated with increased risk of the early aseptic loosening susceptibility.

Virtual Slides

The virtual slide(s) for this article can be found here: http://​www.​diagnosticpathol​ogy.​diagnomx.​eu/​vs/​13000_​2014_​177
Literature
1.
Schwarzkopf R, Mikhael B, Wright E, Estok DM, Katz JN: Treatment failure among infected periprosthetic total hip arthroplasty patients. Open Orthop J. 2014, 8: 118-124. 10.2174/1874325020140515002.PubMedPubMedCentralCrossRef
2.
Liu SS, Della Valle AG, Besculides MC, Gaber LK, Memtsoudis SG: Trends in mortality, complications, and demographics for primary hip arthroplasty in the United States. Int Orthop. 2009, 33: 643-651. 10.1007/s00264-008-0549-4.PubMedPubMedCentralCrossRef
3.
Ackerman IN, Graves SE, Bennell KL, Osborne RH: Evaluating quality of life in hip and knee replacement: Psychometric properties of the World Health Organization Quality of Life short version instrument. Arthritis Rheum. 2006, 55: 583-590. 10.1002/art.22107.PubMedCrossRef
4.
Barrett J, Losina E, Baron JA, Mahomed NN, Wright J, Katz JN: Survival following total hip replacement. J Bone Joint Surg Am. 2005, 87: 1965-1971. 10.2106/JBJS.D.02440.PubMedCrossRef
5.
Kurtz S, Ong K, Lau E, Mowat F, Halpern M: Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030. J Bone Joint Surg Am. 2007, 89: 780-785. 10.2106/JBJS.F.00222.PubMedCrossRef
6.
Crowninshield RD, Rosenberg AG, Sporer SM: Changing demographics of patients with total joint replacement. Clin Orthop Relat Res. 2006, 443: 266-272. 10.1097/01.blo.0000188066.01833.4f.PubMedCrossRef
7.
Buckwalter JA, Saltzman C, Brown T: The impact of osteoarthritis: implications for research. Clin Orthop Relat Res. 2004, 10: S6-15. 10.1097/01.blo.0000143938.30681.9d.CrossRef
8.
Glant TT, Jacobs JJ: Response of three murine macrophage populations to particulate debris: bone resorption in organ cultures. J Orthop Res. 1994, 12: 720-731. 10.1002/jor.1100120515.PubMedCrossRef
9.
Maloney WJ, Smith RL, Schmalzried TP, Chiba J, Huene D, Rubash H: Isolation and characterization of wear particles generated in patients who have had failure of a hip arthroplasty without cement. J Bone Joint Surg Am. 1995, 77: 1301-1310.PubMed
10.
Mulroy WF, Harris WH: Revision total hip arthroplasty with use of so-called second-generation cementing techniques for aseptic loosening of the femoral component. A fifteen-year-average follow-up study. J Bone Joint Surg Am. 1996, 78: 325-330.PubMed
11.
Gallo J, Raska M, Mrazek F, Petrek M: Bone remodeling, particle disease and individual susceptibility to periprosthetic osteolysis. Physiol Res. 2008, 57: 339-349.PubMed
12.
Goodman SB, Gomez Barrena E, Takagi M, Konttinen YT: Biocompatibility of total joint replacements: A review. J Biomed Mater Res A. 2009, 90: 603-618. 10.1002/jbm.a.32063.PubMedCrossRef
13.
Gallo J, Kaminek P, Ticha V, Rihakova P, Ditmar R: Particle disease. A comprehensive theory of periprosthetic osteolysis: a review. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2002, 146: 21-28. 10.5507/bp.2002.004.PubMedCrossRef
14.
Jacobs CA, Christensen CP, Berend ME: Sport activity after total hip arthroplasty: changes in surgical technique, implant design, and rehabilitation. J Sport Rehabil. 2009, 18: 47-59.PubMed
15.
Wang Z, Zhang Y, Kong X, Li S, Hu Y, Wang R, Li Y, Lu C, Lin N, Chen W: Association of a polymorphism in PON-1 gene with steroid-induced osteonecrosis of femoral head in Chinese Han population. Diagn Pathol. 2013, 8: 186-10.1186/1746-1596-8-186.PubMedPubMedCentralCrossRef
16.
Zhang Y, Wang R, Li S, Kong X, Wang Z, Chen W, Lin N: Genetic polymorphisms in plasminogen activator inhibitor-1 predict susceptibility to steroid-induced osteonecrosis of the femoral head in Chinese population. Diagn Pathol. 2013, 8: 169-10.1186/1746-1596-8-169.PubMedPubMedCentralCrossRef
17.
Lamblin N, Bauters C, Hermant X, Lablanche JM, Helbecque N, Amouyel P: Polymorphisms in the promoter regions of MMP-2, MMP-3, MMP-9 and MMP-12 genes as determinants of aneurysmal coronary artery disease. J Am Coll Cardiol. 2002, 40: 43-48. 10.1016/S0735-1097(02)01909-5.PubMedCrossRef
18.
Peters DG, Kassam A, St Jean PL, Yonas H, Ferrell RE: Functional polymorphism in the matrix metalloproteinase-9 promoter as a potential risk factor for intracranial aneurysm. Stroke. 1999, 30: 2612-2616. 10.1161/01.STR.30.12.2612.PubMedCrossRef
19.
de Souza AP, Trevilatto PC, Scarel-Caminaga RM, Brito RB, Line SR: MMP-1 promoter polymorphism: association with chronic periodontitis severity in a Brazilian population. J Clin Periodontol. 2003, 30: 154-158. 10.1034/j.1600-051X.2003.300202.x.PubMedCrossRef
20.
Kanamori Y, Matsushima M, Minaguchi T, Kobayashi K, Sagae S, Kudo R, Terakawa N, Nakamura Y: Correlation between expression of the matrix metalloproteinase-1 gene in ovarian cancers and an insertion/deletion polymorphism in its promoter region. Cancer Res. 1999, 59: 4225-4227.PubMed
21.
Fujimoto T, Parry S, Urbanek M, Sammel M, Macones G, Kuivaniemi H, Romero R, Strauss JF: A single nucleotide polymorphism in the matrix metalloproteinase-1 (MMP-1) promoter influences amnion cell MMP-1 expression and risk for preterm premature rupture of the fetal membranes. J Biol Chem. 2002, 277: 6296-6302. 10.1074/jbc.M107865200.PubMedCrossRef
22.
Gepstein A, Shapiro S, Arbel G, Lahat N, Livne E: Expression of matrix metalloproteinases in articular cartilage of temporomandibular and knee joints of mice during growth, maturation, and aging. Arthritis Rheum. 2002, 46: 3240-3250. 10.1002/art.10690.PubMedCrossRef
23.
Kerkela E, Bohling T, Herva R, Uria JA, Saarialho-Kere U: Human macrophage metalloelastase (MMP-12) expression is induced in chondrocytes during fetal development and malignant transformation. Bone. 2001, 29: 487-493. 10.1016/S8756-3282(01)00595-6.PubMedCrossRef
24.
Godoy-Santos AL, D'Elia CO, Teixeira WJ, Cabrita HB, Camanho GL: Aseptic loosening of total hip arthroplasty: preliminary genetic investigation. J Arthroplasty. 2009, 24: 297-302. 10.1016/j.arth.2008.08.006.PubMedCrossRef
25.
Malik MH, Jury F, Bayat A, Ollier WE, Kay PR: Genetic susceptibility to total hip arthroplasty failure: a preliminary study on the influence of matrix metalloproteinase 1, interleukin 6 polymorphisms and vitamin D receptor. Ann Rheum Dis. 2007, 66: 1116-1120. 10.1136/ard.2006.062018.PubMedPubMedCentralCrossRef
26.
Walsh PS, Metzger DA, Higuchi R: Chelex 100 as a medium for simple extraction of DNA for PCR-based typing from forensic material. Biotechniques. 1991, 10: 506-513.PubMed
27.
Golub LM, Lee HM, Greenwald RA, Ryan ME, Sorsa T, Salo T, Giannobile WV: A matrix metalloproteinase inhibitor reduces bone-type collagen degradation fragments and specific collagenases in gingival crevicular fluid during adult periodontitis. Inflamm Res. 1997, 46: 310-319. 10.1007/s000110050193.PubMedCrossRef
28.
Yamada Y, Ando F, Niino N, Shimokata H: Association of a polymorphism of the matrix metalloproteinase-1 gene with bone mineral density. Matrix Biol. 2002, 21: 389-392. 10.1016/S0945-053X(02)00030-6.PubMedCrossRef
29.
Dunleavey L, Beyzade S, Ye S: Rapid genotype analysis of the matrix metalloproteinase-1 gene 1G/2G polymorphism that is associated with risk of cancer. Matrix Biol. 2000, 19: 175-177. 10.1016/S0945-053X(00)00059-7.PubMedCrossRef
30.
Holliday LS, Welgus HG, Fliszar CJ, Veith GM, Jeffrey JJ, Gluck SL: Initiation of osteoclast bone resorption by interstitial collagenase. J Biol Chem. 1997, 272: 22053-22058. 10.1074/jbc.272.35.22053.PubMedCrossRef
31.
Vincenti MP, White LA, Schroen DJ, Benbow U, Brinckerhoff CE: Regulating expression of the gene for matrix metalloproteinase-1 (collagenase): mechanisms that control enzyme activity, transcription, and mRNA stability. Crit Rev Eukaryot Gene Expr. 1996, 6: 391-411. 10.1615/CritRevEukarGeneExpr.v6.i4.40.PubMedCrossRef
32.
Takagi M, Konttinen YT, Santavirta S, Sorsa T, Eisen AZ, Nordsletten L, Suda A: Extracellular matrix metalloproteinases around loose total hip prostheses. Acta Orthop Scand. 1994, 65: 281-286. 10.3109/17453679408995454.PubMedCrossRef
33.
Li TF, Santavirta S, Virtanen I, Kononen M, Takagi M, Konttinen YT: Increased expression of EMMPRIN in the tissue around loosened hip prostheses. Acta Orthop Scand. 1999, 70: 446-451. 10.3109/17453679909000979.PubMedCrossRef
34.
Imai S, Konttinen YT, Jumppanen M, Lindy O, Ceponis A, Kemppinen P, Sorsa T, Santavirta S, Xu JW, Lopez-Otin C: High levels of expression of collagenase-3 (MMP-13) in pathological conditions associated with a foreign-body reaction. J Bone Joint Surg (Br). 1998, 80: 701-710. 10.1302/0301-620X.80B4.7952.CrossRef
35.
Takei I, Takagi M, Santavirta S, Ida H, Ishii M, Ogino T, Ainola M, Konttinen YT: Messenger ribonucleic acid expression of 16 matrix metalloproteinases in bone-implant interface tissues of loose artificial hip joints. J Biomed Mater Res. 2000, 52: 613-620. 10.1002/1097-4636(20001215)52:4<613::AID-JBM5>3.0.CO;2-8.PubMedCrossRef
36.
Ma GF, Ali A, Verzijl N, Hanemaaijer R, TeKoppele J, Konttinen YT, Salo J: Increased collagen degradation around loosened total hip replacement implants. Arthritis Rheum. 2006, 54: 2928-2933. 10.1002/art.22064.PubMedCrossRef
37.
Bachmann HS, Hanenkamp S, Kornacki B, Frey UH, Bau M, Siffert W, Wedemeyer C: Gender-dependent association of the GNAS1 T393C polymorphism with early aseptic loosening after total hip arthroplasty. J Orthop Res. 2008, 26: 1562-1568. 10.1002/jor.20699.PubMedCrossRef
38.
Gallo J, Mrazek F, Petrek M: Variation in cytokine genes can contribute to severity of acetabular osteolysis and risk for revision in patients with ABG 1 total hip arthroplasty: a genetic association study. BMC Med Genet. 2009, 10: 109-10.1186/1471-2350-10-109.PubMedPubMedCentralCrossRef
39.
Rasquinha VJ, Dua V, Rodriguez JA, Ranawat CS: Fifteen-year survivorship of a collarless, cemented, normalized femoral stem in primary hybrid total hip arthroplasty with a modified third-generation cement technique. J Arthroplasty. 2003, 18: 86-94. 10.1016/S0883-5403(03)00300-0.PubMedCrossRef
40.
Hegemann N, Kohn B, Brunnberg L, Schmidt MF: Biomarkers of joint tissue metabolism in canine osteoarthritic and arthritic joint disorders. Osteoarthritis Cartilage. 2002, 10: 714-721. 10.1053/joca.2002.0820.PubMedCrossRef
41.
Malik MH, Gambhir AK, Bale L, Pradhan N, Porter ML: Primary total hip replacement: a comparison of a nationally agreed guide to best practice and current surgical technique as determined by the North West Regional Arthroplasty Register. Ann R Coll Surg Engl. 2004, 86: 113-118. 10.1308/003588404322827509.PubMedPubMedCentralCrossRef
Metadata
Title
Genetic susceptibility to total hip arthroplasty failure: a case-control study on the influence of MMP 1 gene polymorphism
Authors
Yiguo Yan
Jianzhong Hu
Hongbin Lu
Wenjun Wang
Publication date
01-12-2014
Publisher
BioMed Central
Published in
Diagnostic Pathology / Issue 1/2014
Electronic ISSN: 1746-1596
DOI
https://doi.org/10.1186/s13000-014-0177-9

Other articles of this Issue 1/2014

Diagnostic Pathology 1/2014 Go to the issue

Short report

HMG-CoA reductase expression in primary colorectal cancer correlates with favourable clinicopathological characteristics and an improved clinical outcome

Research

RETRACTED ARTICLE: Gene expression profiles analysis identifies key genes for acute lung injury in patients with sepsis

Research

Activation of P21-activated protein kinase 2 is an independent prognostic predictor for patients with gastric cancer

Research

Use of a standardized diagnostic approach improves the prognostic information of histopathologic factors in pancreatic and periampullary adenocarcinoma

Research

Serum level of DKK-1 and its prognostic potential in non–small cell lung cancer

Research

Up-regulation of miR-9 expression predicate advanced clinicopathological features and poor prognosis in patients with hepatocellular carcinoma