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Journal of Occupational Medicine and Toxicology
Published in: Journal of Occupational Medicine and Toxicology 1/2018

Open Access 01-12-2018 | Research

Association of plasma PCB levels and HbA1c concentration in Iran

Published in: Journal of Occupational Medicine and Toxicology | Issue 1/2018

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Abstract

Background

The rapid increase in prevalence of diabetes mellitus over the last decades warrants more attention to the effects of environmental and occupational exposures on glucose metabolism. Our study aimed to assess the association between the plasma levels of various congeners of polychlorinated biphenyls (PCBs) and the serum concentration of glycated haemoglobin (HbA1c).

Methods

Our study population consisted of 140 Iranian adults from seven different occupational groups and a group of non-occupationally exposed female participants. The plasma concentration of PCBs were determined at the laboratory of occupational toxicology at RWTH Aachen University, Germany. We considered an HbA1c concentration of 5.7% and more as indicating a disturbed glucose metabolism. Logistic regression was used to assess the association between quartiles of concentrations of PCB congeners and serum HbA1c.

Results

Participants with an increased HbA1c value had higher plasma levels of PCB 138, 153, 180 and the PCB sum, although this association was statistically not significant. There was no significant difference between the levels of PCB 138, 153, 180, the sum of these congeners, and PCB 118 in their quartiles when comparing with HbA1c concentrations.

Conclusions

For our cohort, we could not demonstrate a significant association between PCB and HbA1c concentrations indicating a disturbance of glucose metabolism.
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Metadata
Title
Association of plasma PCB levels and HbA1c concentration in Iran
Publication date
01-12-2018
Published in
Journal of Occupational Medicine and Toxicology / Issue 1/2018
Electronic ISSN: 1745-6673
DOI
https://doi.org/10.1186/s12995-018-0199-4

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