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Behavioral and Brain Functions
Published in: Behavioral and Brain Functions 1/2015

Open Access 01-12-2016 | Research

Brain activation differences in schizophrenia during context-dependent processing of saccade tasks

Authors: A. L. Rodrigue, B. P. Austin, K. A. Dyckman, J. E. McDowell

Published in: Behavioral and Brain Functions | Issue 1/2015

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Abstract

Background

Brain function in schizophrenia has been probed using saccade paradigms and functional magnetic resonance imaging, but little information exists about how changing task context impacts saccade related brain activation and behavioral performance. We recruited schizophrenia and comparison subjects to perform saccade tasks in differing contexts: (1) two single task runs (anti- or pro-saccades alternating with fixation) and (2) one dual task run (antisaccades alternating with prosaccades).

Results

Context-dependent differences in saccade circuitry were evaluated using ROI analyses. Distinction between anti- and pro-saccade activation across contexts (single versus dual task) suggests that the schizophrenia group did not respond to context in the same way as the comparison group.

Conclusions

Further investigation of context processing effects on brain activation and saccade performance measures informs models of cognitive deficits in the disorder and enhances understanding of antisaccades as a potential endophenotype for schizophrenia.
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Metadata
Title
Brain activation differences in schizophrenia during context-dependent processing of saccade tasks
Authors
A. L. Rodrigue
B. P. Austin
K. A. Dyckman
J. E. McDowell
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Behavioral and Brain Functions / Issue 1/2015
Electronic ISSN: 1744-9081
DOI
https://doi.org/10.1186/s12993-016-0103-2

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