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Annals of General Psychiatry
Published in: Annals of General Psychiatry 1/2019

Open Access 01-12-2019 | Tic Disorder | Primary research

Randomized controlled clinical trial comparing the efficacy and tolerability of aripiprazole and sodium valproate in the treatment of Tourette syndrome

Authors: Deshuang Tao, Tangwu Zhong, Shuxia Ma, Jialin Li, Xiaojie Li

Published in: Annals of General Psychiatry | Issue 1/2019

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Abstract

Objective

This study compared the efficacy and tolerability of sodium valproate and aripiprazole in the treatment of Tourette syndrome (TS).

Method

24 children and adolescents with a diagnosis of TS from the Jiamusi Central Hospital between January 2014 and August 2017 were randomly divided into sodium valproate group and aripiprazole group according to the order of clinic visits and treated for 10 days. Tic severity was rated using the Yale Global Tic Severity Scale (YGTSS) and the Clinical Global Impressions Scale for tics (CGI-Tics) and the adverse reactions were valued using the Treatment Emergent Symptom Scale (TESS) at baseline and at each follow-up visit.

Results

The TTS score in the YGTSS scale decreased over time in both groups while the aripiprazole group was significantly higher on the 5th day (p < 0.05) and 10th day (p < 0.05) than the sodium valproate group. There was no significant difference in TESS score between the two groups.

Conclusions

The study indicates that the patients treated with sodium valproate injection have a faster onset time than the patients treated with oral aripiprazole in controlling tics.
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Metadata
Title
Randomized controlled clinical trial comparing the efficacy and tolerability of aripiprazole and sodium valproate in the treatment of Tourette syndrome
Authors
Deshuang Tao
Tangwu Zhong
Shuxia Ma
Jialin Li
Xiaojie Li
Publication date
01-12-2019
Publisher
BioMed Central
Published in
Annals of General Psychiatry / Issue 1/2019
Electronic ISSN: 1744-859X
DOI
https://doi.org/10.1186/s12991-019-0245-3

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