Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Annals of General Psychiatry
Published in: Annals of General Psychiatry 1/2019

Open Access 01-12-2019 | Suicide | Primary research

White matter abnormalities of corpus callosum in patients with bipolar disorder and suicidal ideation

Authors: Ran Zhang, Xiaowei Jiang, Miao Chang, Shengnan Wei, Yanqing Tang, Fei Wang

Published in: Annals of General Psychiatry | Issue 1/2019

Login to get access

Abstract

Objective

Although many studies have shown that the corpus callosum (CC) may play an important role in bipolar disorder (BD) and suicide, the pathophysiological mechanism of BD underlying suicidal behavior is still unclear. This study aimed to explore the relationship between the CC, and BD and suicidal ideation using diffusion tensor imaging (DTI).

Method

A total of 203 participants (47 BD patients with suicidal ideation, 59 with BD without suicidal ideation, and 97 healthy controls [HC]) underwent DTI scanning at a single site. We examined the white matter integrity of the CC in the three groups.

Results

A comparison among groups showed that BD patients with suicidal ideation had significant lower fractional anisotropy (FA) values than those of BD without suicidal ideation and HCs in the body and genu of the CC, and FA values of BD without suicidal ideation were significantly lower than those of HCs. However, in the splenium of corpus callosum, no difference was found between BD without suicidal ideation and HCs.

Conclusions

Our findings add to the evidence suggesting that the CC plays a key role in BD with suicidal ideation, especially with respect to the role of the genu and body of the CC subserving emotion regulation.
Appendix
Available only for authorised users
Literature
1.
Gliatto MF, Rai AK. Evaluation and treatment of patients with suicidal ideation. Am Fam Physician. 1999;59(6):1500–6.PubMed
2.
Baldessarini RJ, Faedda GL. Antidepressant-associated mood-switching and transition from unipolar major depression to bipolar disorder: a review. J Affect Disord. 2013;148(1):129–35.PubMedCrossRef
3.
Kutcher S, Chehil S. Suicide risk management: a manual for health professionals. New York: Wiley; 2007.CrossRef
4.
5.
Pompili M, Ehrlich S, De PE, Mann JJ, Innamorati M, Cittadini A, Montagna B, Iliceto P, Romano A, Amore M. White matter hyperintensities and their associations with suicidality in patients with major affective disorders. Eur Arch Psychiatry Clin Neurosci. 2007;257(8):494–9.PubMedCrossRef
6.
Pompili M, Innamorati M, Mann JJ, Oquendo MA, Lester D, Del Casale A, Serafini G, Rigucci S, Romano A, Tamburello A, et al. Periventricular white matter hyperintensities as predictors of suicide attempts in bipolar disorders and unipolar depression. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32(6):1501–7.PubMedCrossRef
7.
Pompili M, Serafini G, Innamorati M, Serra G, Forte A, Lester D, Ducci G, Girardi P, Tatarelli R. White matter hyperintensities, suicide risk and late-onset affective disorders: an overview of the current literature. La Clinica terapeutica. 2010;161(6):555–63.PubMed
8.
Serafini G, Pompili M, Innamorati M, Fusarpoli P, Akiskal HS, Rihmer Z, Lester D, Romano A, de Oliveira IR, Strusi L. Affective temperamental profiles are associated with white matter hyperintensity and suicidal risk in patients with mood disorders. J Affect Disord. 2011;129(1):47–55.PubMedCrossRef
9.
Lijffijt M, Rourke ED, Swann AC, Zuntasoares GB, Soares JC. Illness-course modulates suicidality-related prefrontal gray matter reduction in women with bipolar disorder. Acta Psychiatr Scand. 2014;130(5):374–87.PubMedCrossRef
10.
Benedetti F, Riccaboni R, Poletti S, Radaelli D, Locatelli C, Lorenzi C, Pirovano A, Smeraldi E, Colombo C. The serotonin transporter genotype modulates the relationship between early stress and adult suicidality in bipolar disorder. Bipolar Disord. 2014;16(8):857–66.PubMedCrossRef
11.
Giakoumatos CI, Tandon N, Shah J, Mathew IT, Brady RO, Clementz BA, Pearlson GD, Thaker GK, Tamminga CA, Sweeney JA. Are structural brain abnormalities associated with suicidal behavior inpatients with psychotic disorders? J Psychiatr Res. 2013;47(10):1389–95.PubMedPubMedCentralCrossRef
12.
Dgg D, Mcl N, Albuquerque MR, Turecki G, Ding Y, de SouzaDuran FL, Busatto G, Correa H. Structural brain abnormalities in patients with type I bipolar disorder and suicidal behavior. Psychiatry Res. 2017;265:9.CrossRef
13.
Johnston JA, Wang F, Liu J, Blond BN, Wallace A, Liu J, Spencer L, Cox Lippard ET, Purves KL, Landerosweisenberger A. Multimodal neuroimaging of frontolimbic structure and function associated with suicide attempts in adolescents and young adults with bipolar disorder. Am J Psychiatry. 2017;174(7):667–75.PubMedPubMedCentralCrossRef
14.
Rueckert L, Levy J. Further evidence that the callosum is involved in sustaining attention. Neuropsychologia. 1996;34(9):927–35.PubMedCrossRef
15.
Schutter DJ, Harmon-Jones E. The corpus callosum: a commissural road to anger and aggression. Neurosci Biobehav Rev. 2013;37(10):2481–8.PubMedCrossRef
16.
Bloom JS, Hynd GW. The role of the corpus callosum in interhemispheric transfer of information: excitation or inhibition? Neuropsychol Rev. 2005;15(2):59–71.PubMedCrossRef
17.
Paul LK, Van LD, Schieffer B, Dietrich R, Brown WS. Communicative deficits in agenesis of the corpus callosum: nonliteral language and affective prosody. Brain Lang. 2003;85(2):313–24.PubMedCrossRef
18.
19.
Bellani M, Yeh PH, Tansella M, Balestrieri M, Soares JC, Brambilla P. DTI studies of corpus callosum in bipolar disorder. Biochem Soc Trans. 2009;37(Pt 5):1096.PubMedCrossRef
20.
Cyprien F, Champfleur NMD, Deverdun J, Olié E, Bars EL, Bonafé A, Mura T, Jollant F, Courtet P, Artero S. Corpus callosum integrity is affected by mood disorders and also by the suicide attempt history: a diffusion tensor imaging study. J Affect Disord. 2016;206:115–24.PubMedCrossRef
21.
Matsuo K, Nielsen N, Nicoletti MA, Hatch JP, Monkul ES, Watanabe Y, Zuntasoares GB, Nery FG, Soares JC. Anterior genu corpus callosum and impulsivity in suicidal patients with bipolar disorder. Neurosci Lett. 2010;469(1):75–80.PubMedCrossRef
22.
Yasar AS, Monkul ES, Sassi RB. MRI study of corpus callosum in children and adolescents with bipolar disorder. Psychiatry Res Neuroimaging. 2015;146(1):83–5.CrossRef
23.
Beck AT, Kovacs M, Weissman A. Assessment of suicidal ideation: the scale for suicide ideation. J Consult Clin Psychol. 1979;47(2):343–52.PubMedCrossRef
24.
Cui Z, Zhong S, Xu P, He Y, Gong G. PANDA: a pipeline toolbox for analyzing brain diffusion images. Front Hum Neurosci. 2013;7(42):42.PubMedPubMedCentral
25.
Desikan RS, Ségonne F, Fischl B, Quinn BT, Dickerson BC, Blacker D, Buckner RL, Dale AM, Maguire RP, Hyman BT. An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest. Neuroimage. 2006;31(3):968–80.PubMedCrossRef
26.
Rushton A. Gray’s anatomy: the anatomical basis of clinical practice. Int J Ther Rehabil. 2006;13(5):237.
27.
Arnone D, McIntosh AM, Chandra P, Ebmeier KP. Meta-analysis of magnetic resonance imaging studies of the corpus callosum in bipolar disorder. Acta Psychiatr Scand. 2008;118(5):357–62.PubMedCrossRef
28.
Brambilla P, Nicoletti MA, Sassi RB, Mallinger AG, Frank E, Kupfer DJ, Keshavan MS, Soares JC. Magnetic resonance imaging study of corpus callosum abnormalities in patients with bipolar disorder. Biol Psychiat. 2003;54(11):1294–7.PubMedCrossRef
29.
Lloyd AJ, Ali HE, Nesbitt D, Moore PB, Young AH, Ferrier IN. Corpus callosum changes in euthymic bipolar affective disorder. Br J Psychiatry J Ment Sci. 2014;204(2):129–36.CrossRef
30.
Sarrazin S, d’Albis MA, McDonald C, Linke J, Wessa M, Phillips M, Delavest M, Emsell L, Versace A, Almeida J, et al. Corpus callosum area in patients with bipolar disorder with and without psychotic features: an international multicentre study. J Psychiatry Neurosci. 2015;40(5):352–9.PubMedPubMedCentralCrossRef
31.
Nau JY. Suicidal behavior associated with atrophied corpus callosum in the elderly. Revue Medicale Suisse. 2011;7(295):1114–5.PubMed
32.
Cyprien F, Courtet P, Malafosse A, Maller J, Meslin C, Bonafé A, Bars EL, Champfleur NMD, Ritchie K, Artero S. Suicidal behavior is associated with reduced corpus callosum area. Biol Psychiat. 2011;70(4):320–6.PubMedCrossRef
33.
Gifuni AJ, Olie E, Ding Y, Cyprien F, le Bars E, Bonafe A, Courtet P, Jollant F. Corpus callosum volumes in bipolar disorders and suicidal vulnerability. Psychiatry Res Neuroimaging. 2017;262:47–54.PubMedCrossRef
34.
Serafini G, Solano P, Amore M. Suicidal ideation: a comprehensive overview. New York: Nova Science Publishers Inc.; 2015.
35.
Amelia V, Almeida JRC, Stefanie H, Walsh ND, Massimiliano N, Klein CR, Kupfer DJ, Phillips ML. Elevated left and reduced right orbitomedial prefrontal fractional anisotropy in adults with bipolar disorder revealed by tract-based spatial statistics. Arch Gen Psychiatry. 2008;65(9):1041.CrossRef
36.
Sussmann J, Lymer K, Mckirdy J, Moorhead W, Maniega SM, Job D, Hall J, Bastin M, Johnstone E, Lawrie S. White matter abnormalities in bipolar disorder and schizophrenia detected using diffusion tensor magnetic resonance imaging. Bipolar Disord. 2009;98(1):6.
37.
Macritchie KA, Lloyd AM. White matter microstructural abnormalities in euthymic bipolar disorder. Br J Psychiatry. 2010;196(1):52–8.PubMedCrossRef
Metadata
Title
White matter abnormalities of corpus callosum in patients with bipolar disorder and suicidal ideation
Authors
Ran Zhang
Xiaowei Jiang
Miao Chang
Shengnan Wei
Yanqing Tang
Fei Wang
Publication date
01-12-2019
Publisher
BioMed Central
Keywords
Suicide
Suicide
Published in
Annals of General Psychiatry / Issue 1/2019
Electronic ISSN: 1744-859X
DOI
https://doi.org/10.1186/s12991-019-0243-5

Other articles of this Issue 1/2019

Annals of General Psychiatry 1/2019 Go to the issue

Primary research

Suicide prevention by emergency nurses: perceived self-efficacy in assessment, management and referral at Kenyatta National Hospital in Kenya

Primary research

A comparison of sexual desire in opiate-dependent men receiving methadone and buprenorphine maintenance treatment

Case report

Tuberculum sellae meningioma with possible tacrolimus neurotoxicity manifesting as manic-like psychosis after kidney transplantation

Primary research

Positive psychological well-being predicts lower severe pain in the general population: a 2-year follow-up study of the SwePain cohort

Primary research

Prevalence and correlates of common mental disorder among HIV patients attending antiretroviral therapy clinics in Hawassa City, Ethiopia

Primary research

Alcohol consumption in Austrian physicians