Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Annals of General Psychiatry
Published in: Annals of General Psychiatry 1/2019

Open Access 01-12-2019 | Autism Spectrum Disorder | Primary research

Analysis of the SNP rs3747333 and rs3747334 in NLGN4X gene in autism spectrum disorder: a meta-analysis

Authors: Hongli Sun, Ying Yang, Liyu Zhang, Haibin Wu, Huifang Zhang, Hui Li

Published in: Annals of General Psychiatry | Issue 1/2019

Login to get access

Abstract

Background

The SNP rs3747333 and rs3747334 in Neuroligin 4X (NLGN4X) gene have been demonstrated to be associated with the susceptibility to Autism spectrum disorder (ASDs; MIM 209850), but the results are inconsistent. Therefore, a meta-analysis of eligible studies reporting the association between rs3747333 and rs3747334 and ASD was carried out to enhance the reliability of published results.

Methods

A systematic literature search was performed using PubMed, Web of Science, Cochrane Library to search English articles concerning the relation between rs3747333, rs3747334 and ASD up to Sep. 21th, 2017. Summary odds ratios (OR) and 95% confidence interval (CI) were used to evaluate the risk of rs3747333, rs3747334 in the ASD. The heterogeneity and publication bias of the eligible studies were also evaluated.

Results

Six eligible studies involving 1284 subjects (735 patients and 549 healthy controls) were included in this meta-analysis. Overall, the results indicated that there was no significant risk elevation between rs3747333, rs3747334 variants and ASD (OR = 0.39, 95% CI 0.10–1.60). Furthermore, sensitivity analysis and publication bias analysis confirmed this result.

Conclusions

In conclusion, our meta-analysis suggests that the rs3747333, rs3747334 in NLGN4X gene are not frequent causes of ASD.
Appendix
Available only for authorised users
Literature
1.
DSM-5 American Psychiatric Association. Diagnostic and statistical manual of mental disorders. Arlington: American Psychiatric Publishing; 2013.CrossRef
2.
Gauthier J, Bonnel A, Stonge J, Karemera L, Laurent S, Mottron L, Fombonne E, Joober R, Rouleau GA. NLGN3/NLGN4 gene mutations are not responsible for autism in the Quebec population. Am J Med Genet Part B Neuropsychiatr Genet. 2005;132B:74.CrossRef
3.
Xu X, Xiong Z, Zhang L, Liu Y, Lu L, Peng Y, Guo H, Zhao J, Xia K, Hu Z. Variations analysis of NLGN3 and NLGN4X gene in Chinese autism patients. Mol Biol Rep. 2014;41:4133–40.CrossRef
4.
Südhof TC. Neuroligins and neurexins link synaptic function to cognitive disease. Nature. 2008;455:903–11.CrossRef
5.
Volaki K, Pampanos A, Kitsioutzeli S, Vrettou C, Oikonomakis V, Sofocleous C, Kanavakis E. Mutation screening in the Greek population and evaluation of NLGN3 and NLGN4X genes causal factors for autism. Psychiatr Genet. 2013;23:198.CrossRef
6.
Elsabbagh M, Divan G, Koh YJ, Kim YS, Kauchali S, Marcín C, Montiel-Nava C, Patel V, Paula CS, Wang C. Global prevalence of autism and other pervasive developmental disorders. Autism Res. 2012;5:160–79.CrossRef
7.
Liu Y, Du Y, Liu W, Yang C, Liu Y, Wang H, Gong X. Lack of association between NLGN3, NLGN4, SHANK2 and SHANK3 gene variants and autism spectrum disorder in a Chinese population. PLoS ONE. 2013;8:e56639.CrossRef
8.
Wermter AK, Kamp-Becker I, Strauch K, Schulte-Körne G, Remschmidt H. No evidence for involvement of genetic variants in the X-linked neuroligin genes NLGN3 and NLGN4X in probands with autism spectrum disorder on high functioning level. Am J Med Genet B Neuropsychiatr Genet. 2008;147B:535–7.CrossRef
9.
Underwood E. People on autism spectrum die 18 years younger than average. Science. 2016.
10.
Francesca B, Bacchelli E, Pesaresi G, Carone S, Bailey AJ, Maestrini E. Absence of coding mutations in the X-linked genes neuroligin 3 and neuroligin 4 in individuals with autism from the IMGSAC collection. Am J Med Genet Part B Neuropsychiatr Genet. 2006;141B:220.CrossRef
11.
Gauthier J, Bonnel A, St-Onge J, Karemera L, Laurent S, Mottron L, Fombonne E, Joober R, Rouleau GA. NLGN3/NLGN4 gene mutations are not responsible for autism in the Quebec population. Am J Med Genet B Neuropsychiatr Genet. 2005;132B:74–5.CrossRef
12.
Chaste P, Leboyer M. Autism risk factors: genes, environment, and gene-environment interactions. Dialogues Clin Neurosci. 2012;14:281.PubMedPubMedCentral
13.
Avdjieva-Tzavella DM, Todorov TP, Todorova AP, Kirov AV, Hadjidekova SP, Rukova BB, Litvinenko IO, Hristova-Naydenova DN, Tincheva RS, Toncheva DI. Analysis of the genes encoding neuroligins NLGN3 and NLGN4 in Bulgarian patients with autism. Genet Couns. 2012;23:505–11.PubMed
14.
Mikhailov A, Fennell A, Plong-On O, Sripo T, Hansakunachai T, Roongpraiwan R, Sombuntham T, Ruangdaraganon N, Vincent JB, Limprasert P. Screening of NLGN3 and NLGN4X genes in Thai children with autism spectrum disorder. Psychiatr Genet. 2014;24:42–3.CrossRef
15.
Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions, vol. 5. Wiley Online Library; 2008.
16.
Holmans P. Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia. Mol Autism. 2017;8:21.CrossRef
17.
Lawson-Yuen A, Saldivar JS, Sommer S, Picker J. Familial deletion within NLGN4 associated with autism and Tourette syndrome. Eur J Hum Genet. 2008;16:614–8.CrossRef
18.
Laumonnier F, Bonnet-Brilhault F, Gomot M, Blanc R, David A, Moizard MP, Raynaud M, Ronce N, Lemonnier E, Calvas P, Laudier B, Chelly J, Fryns JP, Ropers HH, Hamel BC, Andres C, Barthelemy C, Moraine C, Briault S. X-linked mental retardation and autism are associated with a mutation in the NLGN4 gene, a member of the neuroligin family. Am J Hum Genet. 2004;74:552–7.CrossRef
19.
Blasi F, Bacchelli E, Pesaresi G, Carone S, Bailey AJ, Maestrini E. Absence of coding mutations in the X-linked genes neuroligin 3 and neuroligin 4 in individuals with autism from the IMGSAC collection. Am J Med Genet B Neuropsychiatr Genet. 2006;141B:220–1.CrossRef
Metadata
Title
Analysis of the SNP rs3747333 and rs3747334 in NLGN4X gene in autism spectrum disorder: a meta-analysis
Authors
Hongli Sun
Ying Yang
Liyu Zhang
Haibin Wu
Huifang Zhang
Hui Li
Publication date
01-12-2019
Publisher
BioMed Central
Published in
Annals of General Psychiatry / Issue 1/2019
Electronic ISSN: 1744-859X
DOI
https://doi.org/10.1186/s12991-019-0227-5

Other articles of this Issue 1/2019

Annals of General Psychiatry 1/2019 Go to the issue

Primary research

Modeling human temperament and character on the basis of combined theoretical approaches

Primary research

Socio-demographic and substance-related factors associated with mental distress among Wollo university students: institution-based cross-sectional study

Primary research

Alcohol consumption in Austrian physicians

Primary research

Factor structure and diagnostic efficiency of the Myanmar version BDI-II among substance users

Primary research

Mental health profile and its relation with parental alcohol use problems and/or the experience of abuse in a sample of Moroccan high school students: an explorative study

Primary research

Randomized controlled clinical trial comparing the efficacy and tolerability of aripiprazole and sodium valproate in the treatment of Tourette syndrome