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Fluids and Barriers of the CNS
Published in: Fluids and Barriers of the CNS 1/2022

Open Access 01-12-2022 | Review

Cerebrospinal fluid production by the choroid plexus: a century of barrier research revisited

Authors: Nanna MacAulay, Richard F. Keep, Thomas Zeuthen

Published in: Fluids and Barriers of the CNS | Issue 1/2022

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Abstract

Cerebrospinal fluid (CSF) envelops the brain and fills the central ventricles. This fluid is continuously replenished by net fluid extraction from the vasculature by the secretory action of the choroid plexus epithelium residing in each of the four ventricles. We have known about these processes for more than a century, and yet the molecular mechanisms supporting this fluid secretion remain unresolved. The choroid plexus epithelium secretes its fluid in the absence of a trans-epithelial osmotic gradient, and, in addition, has an inherent ability to secrete CSF against an osmotic gradient. This paradoxical feature is shared with other ‘leaky’ epithelia. The assumptions underlying the classical standing gradient hypothesis await experimental support and appear to not suffice as an explanation of CSF secretion. Here, we suggest that the elusive local hyperosmotic compartment resides within the membrane transport proteins themselves. In this manner, the battery of plasma membrane transporters expressed in choroid plexus are proposed to sustain the choroidal CSF secretion independently of the prevailing bulk osmotic gradient.
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Metadata
Title
Cerebrospinal fluid production by the choroid plexus: a century of barrier research revisited
Authors
Nanna MacAulay
Richard F. Keep
Thomas Zeuthen
Publication date
01-12-2022
Publisher
BioMed Central
Published in
Fluids and Barriers of the CNS / Issue 1/2022
Electronic ISSN: 2045-8118
DOI
https://doi.org/10.1186/s12987-022-00323-1

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