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Virology Journal
Published in: Virology Journal 1/2024

Open Access 01-12-2024 | SARS-CoV-2 | Review

Mechanisms and consequences of mRNA destabilization during viral infections

Authors: Soraya I. Shehata, J. Monty Watkins, James M. Burke, Roy Parker

Published in: Virology Journal | Issue 1/2024

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Abstract

During viral infection there is dynamic interplay between the virus and the host to regulate gene expression. In many cases, the host induces the expression of antiviral genes to combat infection, while the virus uses “host shut-off” systems to better compete for cellular resources and to limit the induction of the host antiviral response. Viral mechanisms for host shut-off involve targeting translation, altering host RNA processing, and/or inducing the degradation of host mRNAs. In this review, we discuss the diverse mechanisms viruses use to degrade host mRNAs. In addition, the widespread degradation of host mRNAs can have common consequences including the accumulation of RNA binding proteins in the nucleus, which leads to altered RNA processing, mRNA export, and changes to transcription.
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Metadata
Title
Mechanisms and consequences of mRNA destabilization during viral infections
Authors
Soraya I. Shehata
J. Monty Watkins
James M. Burke
Roy Parker
Publication date
01-12-2024
Publisher
BioMed Central
Published in
Virology Journal / Issue 1/2024
Electronic ISSN: 1743-422X
DOI
https://doi.org/10.1186/s12985-024-02305-1

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