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Reproductive Health
Published in: Reproductive Health 1/2018

Open Access 01-12-2018 | Commentary

Features of randomised trials designed by the NPEU Perinatal Trials Service during Adrian Grant’s directorship

Author: Diana Elbourne

Published in: Reproductive Health | Issue 1/2018

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Abstract

Adrian Grant pioneered methodological innovations in the randomised trials organised by the Perinatal Trials Service established at the national Perinatal Epidemiology Unit in Oxford, UK. This Commentary discusses these innovations, and shows the wide range of trials designed under his directorship.
Appendix
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Literature
1.
2.
Chalmers I, Elbourne D, Grant A. Phenobarbitone and periventricular haemorrhage. Lancet. 1984;1:286.
3.
4.
The Eclampsia Trial Collaborative Group. Which anticonvulsant for women with eclampsia? Evidence from the collaborative eclampsia trial. Lancet. 1995;345:1455–63.CrossRef
5.
MRC Working Party on the Evaluation of Chorion Villus Sampling. Medical Research Council European trial of chorion villus sampling. Lancet. 1991;337:1491–9.CrossRef
6.
Chalmers I, Grant AM. Cervical cerclage. Br J Obstet Gynaecol. 1982;89(7):497–8.CrossRef
7.
Rush RW, Isaacs S, McPherson K, Jones L, Chalmers I, Grant AM. A randomized controlled trial of cervical cerclage in women at high risk of spontaneous preterm delivery. Br J Obstet Gynaecol. 1984;91(8):724–30.CrossRefPubMed
8.
Alexander JM, Grant AM, Campbell MJ. Randomized controlled trial of breast shells and Hoffman's exercises for inverted and non-protractile nipples. Br Med J. 1992;304:1030–2.CrossRef
9.
Grant AM, Elbourne DR, Valentin L, Alexander S. Routine formal fetal movement counting and risk of antepartum late death in normally-formed singletons. Lancet. 1989;2:345–9.CrossRefPubMed
10.
Proud J, Grant AM. Third trimester placental grading by ultrasonography as a test of fetal wellbeing. Br Med J. 1987;294:1641–4.CrossRef
11.
CLASP (Collaborative Low-dose Aspirin Study in Pregnancy) Collaborative Group. CLASP: a randomised trial of low-dose aspirin for the prevention and treatment of pre-eclampsia among 9364 pregnant women. Lancet. 1994;343:619–29.CrossRef
12.
Rotchell YE, Cruickshank JK, Phillips Gay M, Griffiths J, Stewart A, Farrell B, Ayers S, Hennis A, Grant AM, Duley L, Collins RE. Barbados low dose aspirin study in pregnancy (BLASP): a randomised trial for the prevention of pre-eclampsia and its complications. Br J Obstet Gynaecol. 1998;105:286–92.CrossRefPubMed
13.
Olsen SF, Sorensen JD, Secher NJ, Hedegaard M, Henriksen TB, Hansen HS, Grant AM. Randomized controlled trial of the effect of fish-oil supplementation on pregnancy duration. The lancet. 1992. 1992;339(8800):1003–7.
14.
Flint C, Poulengeris P, Grant AM. The ‘Know your Midwife’ scheme - a randomised trial of continuity of care by a team of midwives. Midwifery. 1989;5:11–6.CrossRefPubMed
15.
Oakley A, Rajan L, Grant AM. Social support and pregnancy outcome. Br J Obstet Gynaecol. 1990;97:155–62.CrossRefPubMed
16.
MacDonald D, Grant AM, Sheridan-Pereira M, Boylan P, Chalmers I. The Dublin randomized controlled trial of intrapartum fetal heart rate monitoring. Am J Obstet Gynecol 1985. 1985;152(5):524–39.CrossRef
17.
Garcia J, Corry M, MacDonald D, Elbourne DR, Grant AM. Mothers’ views of continuous electronic fetal heart monitoring and intermittent auscultation in a randomized controlled trial. Birth. 1985;12(2):79–86.CrossRefPubMed
18.
Grant AM. Some answers to questions raised about the Dublin trial. Birth. 1986;13(4):255–6.CrossRef
19.
Grant AM, O'Brien N, Joy M-T, Hennessy E, MacDonald D. Cerebral palsy among children born during the Dublin randomized trial of intrapartum monitoring. Lancet 1989;ii(8674):1233–1236.
20.
Vacca A, Grant AM, Wyatt G, Chalmers I. Portsmouth operative delivery trial: a comparison of vacuum extraction and forceps delivery. Br J Obstet Gynaecol. 1983;90(12):1107–12.CrossRefPubMed
21.
Garcia J, Anderson J, Vacca A, Elbourne DR, Grant AM, Chalmers I. Views of women and their medical and midwifery attendants about instrumental delivery using vacuum extraction and forceps. J Psychosom Obstet Gynaecol. 1985;4:1–9.CrossRef
22.
Carmody F, Grant AM, Mutch LM, Vacca A, Chalmers I. Follow up of babies delivered in a randomized controlled comparison of vacuum extraction and forceps delivery. Acta Obstet Gynecol Scand. 1986;65(7):763–6.CrossRefPubMed
23.
Carmody F, Grant AM, Somchiwong M. Vacuum extraction: a randomized controlled comparison of the new generation cup with the original bird cup. J Perinat Med. 1986;14:95–100.CrossRefPubMed
24.
Needs L, Grant AM, Sleep J, Ayers S, Henson G. A randomized controlled trial to compare three types of fetal scalp electrode. Br J Obstet Gynaecol. 1992;99:302–6.CrossRefPubMed
25.
Sleep J, Grant AM, Garcia J, Elbourne DR, Spencer JAD, Chalmers I. West Berkshire perineal management trial. Br Med J. 1984;289:587–90.CrossRef
26.
Sleep J, Grant AM. West Berkshire perineal management trial: three year follow up. Br Med J. 1987;295:749–51.CrossRef
27.
Mahomed K, Grant AM, Ashurst H, James D. The Southmead perineal suture study. A randomized comparison of suture materials and suturing techniques for repair of perineal trauma. Br J Obstet Gynaecol 1989 1989;96(11):1272–1280.
28.
Spencer JAD, Grant AM, Elbourne DR, Garcia J, Sleep J. A randomized comparison of glycerol-impregnated chromic catgut with untreated chromic catgut for the repair of perineal trauma. Br J Obstet Gynaecol. 1986;93:426–30.CrossRefPubMed
29.
Grant AM, Sleep J, Ashurst H, Spencer JAD. Dyspareunia associated with the use of glycerol-impregnated catgut to repair perineal trauma - report of a three-year follow-up study. Br J Obstet Gynaecol. 1989;96:741–3.CrossRefPubMed
30.
Mackrodt C, Gordon B, Fern E, Ayers S, Truesdale A, Grant AM. The Ipswich childbirth study: 2. A randomised comparison of polyglactin 910 with chromic catgut for postpartum perineal repair. Br J Obstet Gynaecol. 1998;105(4):441–5.CrossRefPubMed
31.
Gordon B, Mackrodt C, Fern E, Truesdale A, Ayers S, Grant AM. The Ipswich childbirth study: 1. A randomised evaluation of two stage postpartum perineal repair leaving the skin unsutured. Br J Obstet Gynaecol. 1998;105(4):435–40.CrossRefPubMed
32.
Grant AM, Gordon B, Mackrodt C, Fern E, Truesdale A, Ayers S. The Ipswich childbirth study: one year follow-up of alternative methods used in perineal repair. Br J Obstet Gynaecol. 2001;108:34–40.
33.
Petrou S, Gordon B, Mackrodt C, Fern E, Ayers S, Grant AM, Truesdale A, McCandlish R. How cost-effective is it to leave perineal skin unsutured? British J Midwifery. 2001;9(4):209–14.CrossRef
34.
35.
Sleep J, Grant AM. Effects of salt and Savlon bath concentrate postpartum. Nurs Times. 1988;84:55–7.PubMed
36.
Everett T, McIntosh J, Grant AM. Ultrasound therapy for persistent postnatal perineal pain and dyspareunia: a randomised placebo-controlled trial. Physiotherapy. 1992;78:263–7.CrossRef
37.
Grant AM, Sleep J, McIntosh J, Ashurst H. Ultrasound and pulsed electromagnetic energy treatment for perineal trauma. A randomized placebo-controlled trial. Br J Obstet Gynaecol. 1989;96:434–9.CrossRefPubMed
38.
Ventriculomegaly Trial Group. Randomised trial of early tapping in neonatal posthaemorrhagic ventricular dilatation. Arch dis child. 1990. 1990;65(1):3–10.
39.
Ventriculomegaly Trial Group. Randomised trial of early tapping in neonatal posthaemorrhagic ventricular dilatation: results at 30 months. Arch dis child. 1994. 1994;70(2):F129–36.
40.
Collaborative Dexamethasone Trial Group. Dexamethasone therapy in neonatal chronic lung disease: an international placebo controlled trial. Pediatrics. 1991;88:421–7.
41.
Jones RAK, Wincott E, Elbourne DR, Grant AM. Controlled trial of dexamethasone in neonatal chronic lung disease: a 3-year follow-up. Pediatrics. 1995;96:897–906.PubMed
42.
The EC Ethamsylate Trial Group. The EC randomised controlled trial of prophylatic ethamsylate for very preterm neonates: early mortality and morbidity. Arch Dis Child. 1994;70:F201–5.CrossRef
43.
Elbourne DR, Ayers S, Dellagrammaticas H, Johnson A, Leloup M, Lenoir-Piat S. EC Ethamsylate trial group. Randomised controlled trial of prophylactic ethamsylate: follow up at 2 years of age. Arch Dis Child. 2001;84:F183–7.CrossRef
44.
OSIRIS Collaborative Group. Early versus delayed neonatal administration of a synthetic surfactant - the judgment of OSIRIS. Lancet. 1992;340:1363–9.CrossRef
45.
UK Collaborative ECMO Trial Group. UK collaborative randomised trial of neonatal extracorporeal membrane oxygenation. Lancet. 1996;348:75–82.CrossRef
46.
Howard S, Mugford M, Normand C, Elbourne DR, Grant AM, Field DJ, Johnson A. A cost effectiveness analysis of neonatal ECMO using existing evidence. Int J Technol Assess Health Care. 1996;12:80–92.CrossRefPubMed
47.
Snowdon C, Garcia J, Elbourne DR. Making sense of randomization: responses of parents of critically ill babies to random allocation of treatment in a clinical trial. Soc Sci Med. 1997;45:1337–55.CrossRefPubMed
48.
Snowdon C, Garcia J, Elbourne DR. Reactions of participants to the results of a randomised controlled trial: exploratory study. Br Med J. 1998;317:21–6.CrossRef
49.
Snowdon C, Elbourne DR, Garcia J. Zelen randomization: attitudes of parents participating in a neonatal clinical trial. Control Clin Trials. 1999;20:149–71.CrossRefPubMed
50.
Bennett CC, Johnson A, Field DJ, Elbourne DR. For the UK collaborative ECMO trial group. UK collaborative randomised trial of neonatal extracorporeal membrane oxygenation: follow-up to age 4 years. Lancet. 2001;357:1094–6.CrossRefPubMed
51.
Petrou S, Edwards L. Cost-effectiveness analysis of neonatal extracorporeal membrane oxygenation based on four year results from the UK collaborative ECMO trial. Arch Dis Child. 2004;89:F263–F8.CrossRef
52.
Petrou S, Bischof M, Bennett CC, Elbourne DR, Field DJ, McNally H. Cost-effectiveness of neonatal extracorporeal membrane oxygenation based on 7 year results from the United Kingdom collaborative ECMO trial. Pediatrics. 2006;117:1640–9.CrossRefPubMed
53.
McNally H, Bennett CC, Elbourne DR, Field DJ. For the UK collaborative ECMO trial group. United Kingdom collaborative randomized trial of neonatal extracorporeal membrane oxygenation: follow-up to age 7 years. Pediatrics. 2006;117:845–54.CrossRef
Metadata
Title
Features of randomised trials designed by the NPEU Perinatal Trials Service during Adrian Grant’s directorship
Author
Diana Elbourne
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Reproductive Health / Issue 1/2018
Electronic ISSN: 1742-4755
DOI
https://doi.org/10.1186/s12978-018-0567-7

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