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Journal of Neuroinflammation
Published in: Journal of Neuroinflammation 1/2016

Open Access 01-12-2016 | Short report

Repetitive transcranial magnetic stimulation reduces remote apoptotic cell death and inflammation after focal brain injury

Authors: Valeria Sasso, Elisa Bisicchia, Laura Latini, Veronica Ghiglieri, Fabrizio Cacace, Valeria Carola, Marco Molinari, Maria Teresa Viscomi

Published in: Journal of Neuroinflammation | Issue 1/2016

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Abstract

Background

After focal brain injuries occur, in addition to the effects that are attributable to the primary site of damage, the resulting functional impairments depend highly on changes that occur in regions that are remote but functionally connected to the site of injury. Such effects are associated with apoptotic and inflammatory cascades and are considered to be important predictors of outcome. Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive technique that is used to treat various central nervous system (CNS) pathologies and enhance functional recovery after brain damage.

Objective

This study examined the efficacy of rTMS in mitigating remote degeneration and inflammation and in improving functional recovery in a model of focal brain damage.

Methods

Rats that were undergoing hemicerebellectomy (HCb) were treated with an rTMS protocol for 7 days, and neuronal death indices, glial activation, and functional recovery were assessed.

Results

rTMS significantly reduced neuronal death and glial activation in remote regions and improved functional recovery.

Conclusions

Our finding opens up a completely new scenario for exploiting the potential of rTMS as an anti-apoptotic and anti-inflammatory treatment.
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Metadata
Title
Repetitive transcranial magnetic stimulation reduces remote apoptotic cell death and inflammation after focal brain injury
Authors
Valeria Sasso
Elisa Bisicchia
Laura Latini
Veronica Ghiglieri
Fabrizio Cacace
Valeria Carola
Marco Molinari
Maria Teresa Viscomi
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Journal of Neuroinflammation / Issue 1/2016
Electronic ISSN: 1742-2094
DOI
https://doi.org/10.1186/s12974-016-0616-5

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