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Journal of Neuroinflammation
Published in: Journal of Neuroinflammation 1/2015

Open Access 01-12-2015 | Research

Malibatol A regulates microglia M1/M2 polarization in experimental stroke in a PPARγ-dependent manner

Authors: Jie Pan, Jia-li Jin, Hui-ming Ge, Kai-lin Yin, Xiang Chen, Li-juan Han, Yan Chen, Lai Qian, Xiao-xi Li, Yun Xu

Published in: Journal of Neuroinflammation | Issue 1/2015

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Abstract

Background

Activation of microglia plays a crucial role in immune and inflammatory processes after ischemic stroke. Microglia is reported with two opposing activated phenotypes, namely, classic phenotype (M1) and the alternative phenotype (M2). Inhibiting M1 while stimulating M2 has been suggested as a potential therapeutic approach in the treatment of stroke.

Findings

In this study, we indicated that a novel natural anti-oxidant extracted from the Chinese plant Hopea hainanensis, malibatol A (MA), decreased the infarct size and alleviated the brain injury after mice middle cerebral artery occlusion (MCAO). MA inhibited expression inflammatory cytokines in not only MCAO mice but also lipopolysaccharide (LPS)-stimulated microglia. Moreover, treatment of MA decreased M1 markers (CD16, CD32, and CD86) and increased M2 markers (CD206, YM-1) while promoting the activation of nuclear receptor PPARγ.

Conclusions

MA has anti-inflammatory effects in MCAO mice in a PPARγ-dependent manner, making it a potential candidate for stroke treatment.
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Metadata
Title
Malibatol A regulates microglia M1/M2 polarization in experimental stroke in a PPARγ-dependent manner
Authors
Jie Pan
Jia-li Jin
Hui-ming Ge
Kai-lin Yin
Xiang Chen
Li-juan Han
Yan Chen
Lai Qian
Xiao-xi Li
Yun Xu
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Journal of Neuroinflammation / Issue 1/2015
Electronic ISSN: 1742-2094
DOI
https://doi.org/10.1186/s12974-015-0270-3

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