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Pediatric Rheumatology

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Open Access 01-12-2017 | Research article

Endothelial function in children with a history of henoch schonlein purpura

Authors: Yonatan Butbul Aviel, Lotem Dafna, Giora Pilar, Riva Brik

Published in: Pediatric Rheumatology | Issue 1/2017

Abstract

Background

Although Henoch-Schonlein purpura (HSP) is the most common form of systemic vasculitis in children, the long term effect of HSP on endothelial function is still not clear. The aim of our study was to evaluate the long term effect of HSP on endothelial function in children and adolescents.

Methods

This research was an observational prospective study. The study group comprised of 19 children diagnosed with HSP. The minimum interval between the diagnosis with HSP and endothelial testing was 5 months.

Endothelial function evaluation was assessed by a noninvasive technology named peripheral arterial tonometry, using an EndoPAT™ device. This method measures blood flow in the limb, in response to arterial occlusion, and calculates a Reactive Hyperemic Index (RHI) as an index of endothelial function. RHI values of the study group were compared to those of a known control group.

Results

Nineteen children and adolescents with HSP underwent endothelial function studies. Endothelial function was compared to that of a known control group comprising of 23 healthy children and adolescents. The two groups had similar characteristics, including age, male to female ratio, height, weight and BMI.

Mean RHI was 1.81 in the study group, and 1.87 in the control group (p = 0.18). Linear regression of the study group, showed a positive correlation between the time interval from HSP diagnosis to participation in the study, and between the RHI value (r = 0.542, p = 0.016). RHI levels were significantly higher in patients who had endothelial function measured more than 6 years since the diagnosis of HSP compared with those patients with less than 6 years follow up (1.98 + 0.74 vs. 1.38 ± 0.43 P = 0.037).

Conclusions

These results suggest that HSP causes short term endothelial dysfunction that improves with time.

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Title: Endothelial function in children with a history of henoch schonlein purpura
Authors: Yonatan Butbul Aviel
Lotem Dafna
Giora Pilar
Riva Brik
Publication date: 01-12-2017
Publisher: BioMed Central
Published in: Pediatric Rheumatology / Issue 1/2017
Electronic ISSN: 1546-0096
DOI: https://doi.org/10.1186/s12969-016-0135-z

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Endothelial function in children with a history of henoch schonlein purpura

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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