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Pediatric Rheumatology

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Open Access 01-12-2016 | Research article

Vitamin D levels in children with familial Mediterranean fever

Authors: Hatice Onur, Hale Aral, Vefik Arica, Gamze Atalay Bercem, Ozgur Kasapcopur

Published in: Pediatric Rheumatology | Issue 1/2016

Abstract

Background

This study aimed to determine whether vitamin D deficiency is more common in children with familial Mediterranean fever (FMF) than in healthy individuals.

Methods

The study group consisted of 100 patients diagnosed with FMF and 50 healthy children. Serum baseline 25-hydroxyvitamin D levels and other related parameters were evaluated.

Results

The mean (standard deviation [SD]) vitamin D levels in patients with FMF and healthy controls were 24.78 (8.35) and 28.70 (11.70) ng/mL, respectively. Patients with FMF had significantly decreased vitamin D levels compared with those in healthy controls (P = 0.039). Vitamin D levels were similar in patients with FMF with different MEFV mutations (P = 0.633). Age was significantly correlated with vitamin D levels (r = −0.235, P = 0.019). In addition, a negative correlation between parathyroid hormone and vitamin D levels was detected (r_s = −0.382, P < 0.0001).

Conclusion

This study demonstrated that vitamin D levels are lower in children with FMF than in healthy controls. We speculate that vitamin D levels should be carefully examined, and nutritional supplementation may be required in patients with FMF. Further studies with larger patient populations are needed to confirm the frequency of vitamin D deficiency in patients with FMF.

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Title: Vitamin D levels in children with familial Mediterranean fever
Authors: Hatice Onur
Hale Aral
Vefik Arica
Gamze Atalay Bercem
Ozgur Kasapcopur
Publication date: 01-12-2016
Publisher: BioMed Central
Published in: Pediatric Rheumatology / Issue 1/2016
Electronic ISSN: 1546-0096
DOI: https://doi.org/10.1186/s12969-016-0089-1

At a glance: The STEP trials

Springer Medicine

Vitamin D levels in children with familial Mediterranean fever

Abstract

Background

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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