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Open Access 01-12-2016 | Short Report

Association between drug intake and incidence of malignancies in patients with Juvenile Idiopathic Arthritis: a nested case–control study

Authors: Swaantje Barth, Jenny Schlichtiger, Betty Bisdorff, Boris Hügle, Hartmut Michels, Katja Radon, Johannes-Peter Haas

Published in: Pediatric Rheumatology | Issue 1/2016

Abstract

Background

Several medications for treatment of Juvenile Idiopathic Arthritis (JIA) are considered to be carcinogenic. Therefore, the aim was to assess whether there is an association between therapeutic interventions and malignancies in JIA patients.

Findings

A nested case–control study was carried out within a retrospective cohort study of 3698 JIA patients diagnosed between 1952 and 2010. All 48 JIA patients with a diagnosis of a malignant tumour and up to four matched controls for each received a questionnaire about their use of medication. Subsequently treatment was compared between cases and controls and analyses performed for 37 cases and 125 controls (response 88.5 %). Treatment with DMARD (84 %) was most frequently used, followed by glucocorticoids (66 %) and immunosuppressives (65 %). Twenty percent reported to have ever been taking biologics. Medication use did not differ significantly between cases and controls.

Conclusions

Our results did not show an association between medications used and malignancies in JIA patients.

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Title: Association between drug intake and incidence of malignancies in patients with Juvenile Idiopathic Arthritis: a nested case–control study
Authors: Swaantje Barth
Jenny Schlichtiger
Betty Bisdorff
Boris Hügle
Hartmut Michels
Katja Radon
Johannes-Peter Haas
Publication date: 01-12-2016
Publisher: BioMed Central
Published in: Pediatric Rheumatology / Issue 1/2016
Electronic ISSN: 1546-0096
DOI: https://doi.org/10.1186/s12969-016-0066-8

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Association between drug intake and incidence of malignancies in patients with Juvenile Idiopathic Arthritis: a nested case–control study

Abstract

Background

Findings

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Findings

Conclusions

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