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Journal of Cardiovascular Magnetic Resonance

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Open Access 01-12-2016 | Research

Ferumoxytol-enhanced magnetic resonance imaging methodology and normal values at 1.5 and 3T

Authors: Colin G. Stirrat, Shirjel R. Alam, Thomas J. MacGillivray, Calum D. Gray, Rachael Forsythe, Marc R. Dweck, John R. Payne, Sanjay K. Prasad, Mark C. Petrie, Roy S. Gardner, Saeed Mirsadraee, Peter A. Henriksen, David E. Newby, Scott I. K. Semple

Published in: Journal of Cardiovascular Magnetic Resonance | Issue 1/2017

Abstract

Background

Ultrasmall superparamagnetic particles of iron oxide (USPIO)-enhanced magnetic resonance imaging (MRI) can detect tissue-resident macrophage activity and identify cellular inflammation. Clinical studies using this technique are now emerging. We aimed to report a range of normal R2* values at 1.5 and 3 T in the myocardium and other tissues following ferumoxytol administration, outline the methodology used and suggest solutions to commonly encountered analysis problems.

Methods

Twenty volunteers were recruited: 10 imaged each at 1.5 T and 3 T. T2* and late gadolinium enhanced (LGE) MRI was conducted at baseline with further T2* imaging conducted approximately 24 h after USPIO infusion (ferumoxytol, 4 mg/kg). Regions of interest were selected in the myocardium and compared to other tissues.

Results

Following administration, USPIO was detected by changes in R2* from baseline (1/T2*) at 24 h in myocardium, skeletal muscle, kidney, liver, spleen and blood at 1.5 T, and myocardium, kidney, liver, spleen, blood and bone at 3 T (p < 0.05 for all). Myocardial changes in R2* due to USPIO were 26.5 ± 7.3 s-1 at 1.5 T, and 37.2 ± 9.6 s-1 at 3 T (p < 0.0001 for both). Tissues showing greatest ferumoxytol enhancement were the reticuloendothelial system: the liver, spleen and bone marrow (216.3 ± 32.6 s-1, 336.3 ± 60.3 s-1, 69.9 ± 79.9 s-1; p < 0.0001, p < 0.0001, p = ns respectively at 1.5 T, and 275.6 ± 69.9 s-1, 463.9 ± 136.7 s-1, 417.9 ± 370.3 s-1; p < 0.0001, p < 0.0001, p < 0.01 respectively at 3 T).

Conclusion

Ferumoxytol-enhanced MRI is feasible at both 1.5 T and 3 T. Careful data selection and dose administration, along with refinements to echo-time acquisition, post-processing and analysis techniques are essential to ensure reliable and robust quantification of tissue enhancement.

Trial registration

ClinicalTrials.gov Identifier - NCT02319278. Registered 03.12.2014.

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Title: Ferumoxytol-enhanced magnetic resonance imaging methodology and normal values at 1.5 and 3T
Authors: Colin G. Stirrat
Shirjel R. Alam
Thomas J. MacGillivray
Calum D. Gray
Rachael Forsythe
Marc R. Dweck
John R. Payne
Sanjay K. Prasad
Mark C. Petrie
Roy S. Gardner
Saeed Mirsadraee
Peter A. Henriksen
David E. Newby
Scott I. K. Semple
Publication date: 01-12-2016
Publisher: BioMed Central
Published in: Journal of Cardiovascular Magnetic Resonance / Issue 1/2017
Electronic ISSN: 1532-429X
DOI: https://doi.org/10.1186/s12968-016-0261-2

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Ferumoxytol-enhanced magnetic resonance imaging methodology and normal values at 1.5 and 3T

Abstract

Background

Methods

Results

Conclusion

Trial registration

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

Trial registration

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