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Reproductive Biology and Endocrinology
Published in: Reproductive Biology and Endocrinology 1/2020

01-12-2020 | Fertility | Research

Does body mass index impact assisted reproductive technology treatment outcomes in gestational carriers

Authors: Noga Fuchs Weizman, Miranda K. Defer, Janice Montbriand, Julia M. Pasquale, Adina Silver, Clifford L. Librach

Published in: Reproductive Biology and Endocrinology | Issue 1/2020

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Abstract

Background

The purpose of this study was to assess whether increased body mass index (BMI) negatively affects assisted reproductive technology (ART) outcomes among gestational carriers.

Methods

A retrospective matched case-control cohort, including all gestational carrier (GC) cycles performed at CReATe Fertility Centre (Toronto, ON, Canada) between 2003 and 2016.

Setting

A Canadian fertility clinic, with a large surrogacy program.

Patients

All gestational carriers that had undergone a cycle completed to a transfer at our clinic, and had BMI and outcome data available, were matched by BMI to infertile patients treated at our clinic during the same years provided they had undergone a cycle completed to a transfer, and had outcomes data available.

Interventions

None.

Main outcome measures

Clinical pregnancies rates, miscarriage rates and live birth rates.

Results

BMI was not a reliable prediction factor of any of the measured outcomes. Importantly, the gestational carrier population had better outcomes and a significantly lower overall incidence of maternal, fetal and neonatal complications when compared with infertile patients, treated at our clinic during the same years.

Conclusion

BMI is not a reliable predictor of outcomes among gestational carriers.
Appendix
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Literature
1.
Utian WH, Sheean L, Goldfarb JM, Kiwi R. Successful pregnancy after in vitro fertilization and embryo transfer from an infertile woman to a surrogate. N Engl J Med. 1985;313(21):1351–2..PubMed
2.
White PM. Hidden from view: Canadian gestational surrogacy practices and outcomes, 2001-2012. Reprod Health Matters. 2016;24(47):205–17.PubMedCrossRef
3.
Perkins KM, Boulet SL, Levine AD, Jamieson DJ, Kissin DM. Differences in the utilization of gestational surrogacy between states in the U.S. Reprod Biomed Soc Online. 2018;5:1–4.PubMedCrossRef
4.
5.
Stein JC, Colditz AG. The epidemic of obesity. J Clin Endocrinol Metabol. 2004;89(6):2522–5.CrossRef
6.
Swinburn BA, Sacks G, Hall KD, McPherson K, Finegood DT, Moodie ML, et al. The global obesity pandemic: shaped by global drivers and local environments. Lancet. 2011;378(9793):804–14.PubMedCrossRef
7.
Marshall NE, Guild C, Cheng YW, Caughey AB, Halloran DR. Maternal superobesity and perinatal outcomes. Am J Obstet Gynecol. 2012;206(5):417.e1–6.CrossRef
8.
Xie YJ, Peng R, Han L, Zhou X, Xiong Z, Zhang Y, et al. Associations of neonatal high birth weight with maternal pre-pregnancy body mass index and gestational weight gain: a case-control study in women from Chongqing, China. BMJ Open. 2016;6(8):e010935.PubMedPubMedCentralCrossRef
9.
Fuchs F, Senat M-V, Rey E, Balayla J, Chaillet N, Bouyer J, et al. Impact of maternal obesity on the incidence of pregnancy complications in France and Canada. Sci Rep. 2017;7(1):10859.PubMedPubMedCentralCrossRef
10.
Lisonkova S, Muraca GM, Potts J, Liauw J, Chan W-S, Skoll A, et al. Association between Prepregnancy body mass index and severe maternal morbidity. JAMA. 2017;318(18):1777–86.PubMedPubMedCentralCrossRef
11.
Skurnik G, Hurwitz S, McElrath TF, Tsen LC, Duey S, Saxena AR, et al. Labor therapeutics and BMI as risk factors for postpartum preeclampsia: A case-control study. Pregnancy Hypertens. 2017;10:177–81.PubMedPubMedCentralCrossRef
12.
Cheney K, Farber R, Barratt AL, McGeechan K, de Vries B, Ogle R, et al. Population attributable fractions of perinatal outcomes for nulliparous women associated with overweight and obesity, 1990-2014. Med J Aust. 2018;208(3):119–25.PubMedCrossRef
13.
Mitanchez D, Chavatte-Palmer P. Review shows that maternal obesity induces serious adverse neonatal effects and is associated with childhood obesity in their offspring. Acta Paediatr. 2018;107(7):1156–65.PubMedCrossRef
14.
Luke B, Brown MB, Missmer SA, Bukulmez O, Leach R, Stern JE. The effect of increasing obesity on the response to and outcome of assisted reproductive technology: a national study. Fertil Steril. 2011;96(4):820–5.PubMedCrossRef
15.
Christofolini J, Bianco B, Santos G, Adami F, Christofolini D, Barbosa CP. Bariatric surgery influences the number and quality of oocytes in patients submitted to assisted reproduction techniques. Obesity. 2014;22(3):939.PubMedCrossRef
16.
Einarsson S, Bergh C, Friberg B, Pinborg A, Klajnbard A, Karlstrom PO, et al. Weight reduction intervention for obese infertile women prior to IVF: a randomized controlled trial. Hum Reprod. 2017;32(8):1621–30.PubMedCrossRef
17.
Espinós JJ, Polo A, Sánchez-Hernández J, Bordas R, Pares P, Martínez O, et al. Weight decrease improves live birth rates in obese women undergoing IVF: a pilot study. Reprod BioMed Online. 2017;35(4):417–24.PubMedCrossRef
18.
Friedler S, Cohen O, Liberty G, Saar-Ryss B, Meltzer S, Lazer T. Should high BMI be a reason for IVF treatment denial? Gynecol Endocrinol. 2017;33(11):853–6.PubMedCrossRef
19.
Wang J, Davies M, Norman R. Body mass and probability of pregnancy during assisted reproduction treatment: retrospective study. Br Med J. 2000;321(7272):1320–1.CrossRef
20.
Bellver J, Melo MAB, Bosch E, Serra V, Remohi J, Pellicer A. Obesity and poor reproductive outcome: the potential role of the endometrium. Fertil Steril. 2007;88(2):446–51.PubMedCrossRef
21.
Bellver J. Obesity and poor reproductive outcome: female and male body weight matter. Fertil Steril. 2013;99(6):1558.PubMedCrossRef
22.
Brewer CJ, Balen AH. The adverse effects of obesity on conception and implantation. Reproduction. 2010;140(3):347–64.PubMedCrossRef
23.
Luke B. Adverse effects of female obesity and interaction with race on reproductive potential. Fertil Steril. 2017;107(4):868–77.PubMedCrossRef
24.
Sampo AV, Palena C, Ganzer L, Maccari V, Estofan G, Hernandez M. The adverse effect of overweight in assisted reproduction treatment outcomes. JBRA Assist Reprod. 2017;21(3):212–6.PubMedPubMedCentralCrossRef
25.
Kasum M, Orešković S, Čehić E, Lila A, Ejubović E, Soldo D. The role of female obesity on in vitro fertilization outcomes. Gynecol Endocrinol. 2018;34(3):184–8.PubMedCrossRef
26.
Wattanakumtornkul S, Damario MA, Stevens Hall SA, Thornhill AR, Tummon IS. Body mass index and uterine receptivity in the oocyte donation model. Fertil Steril. 2003;80(2):336.PubMedCrossRef
27.
Vilarino FL, Christofolini DM, Rodrigues D, De Souza AMB, Christofolini J, Bianco B, et al. Body mass index and fertility: is there a correlation with human reproduction outcomes? Gynecol Endocrinol. 2011;27(4):232–6.PubMedCrossRef
28.
Insogna IG, Lee MS, Reimers RM, Toth TL. Neutral effect of body mass index on implantation rate after frozen-thawed blastocyst transfer. Fertil Steril. 2017;108(5):770–6.e1.PubMedCrossRef
29.
Ben-Haroush A, Sirota I, Salman L, Son W-Y, Tulandi T, Holzer H, et al. The influence of body mass index on pregnancy outcome following single-embryo transfer. J Am Soc Reprod Med. 2018;35(7):1295–300.
30.
Pfeifer S, Butts S. Recommendations for practices utilizing gestational carriers: a committee opinion. Fertil Steril. 2017;107(2):e3–e10.CrossRef
31.
Deugarte DA, Deugarte CM, Sahakian V. Surrogate obesity negatively impacts pregnancy rates in third-party reproduction. Fertil Steril. 2010;93(3):1008–10.PubMedCrossRef
32.
Coyne K, Whigham LD, O’Leary K, Yaklic JK, Maxwell RA, Lindheim S. Gestational carrier BMI and reproductive, fetal and neonatal outcomes: are the risks the same with increasing obesity? Int J Obesity. 2015;40(1):171–5.CrossRef
33.
Valckx SDM, De Pauw I, De Neubourg D, Inion I, Berth M, Fransen E, et al. BMI-related metabolic composition of the follicular fluid of women undergoing assisted reproductive treatment and the consequences for oocyte and embryo quality. Hum Reprod. 2012;27(12):3531–9.PubMedCrossRef
34.
Matias CV, Sara LW, Nashita P, Paul TS, Annette LB, Jane S, et al. Prediction of uncomplicated pregnancies in obese women: a prospective multicentre study. BMC Med. 2017;15(1):1–10.CrossRef
35.
Perichart-Perera O, Muñoz-Manrique C, Reyes-López A, Tolentino-Dolores M, y Sosa SE, Ramírez-González MC. Metabolic markers during pregnancy and their association with maternal and newborn weight status. PLoS ONE. 2017;12(7):e0180874.PubMedPubMedCentralCrossRef
36.
Provost MP, Acharya KS, Acharya CR, Yeh JS, Steward RG, Eaton JL, et al. Pregnancy outcomes decline with increasing body mass index: analysis of 239,127 fresh autologous in vitro fertilization cycles from the 2008–2010 Society for Assisted Reproductive Technology registry. Fertil Steril. 2016;105(3):663–9.PubMedCrossRef
37.
Faul F, Erdfelder E, Lang A-G, Buchner A. G*power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods. 2007;39(2):175–91.PubMedCrossRef
38.
39.
40.
Murugappan G, Farland LV, Missmer SA, Correia KF, Anchan RM, Ginsburg ES. Gestational carrier in assisted reproductive technology. Fertil Steril. 2018;109(3):420–8.PubMedCrossRef
41.
Cimadomo D, Fabozzi G, Vaiarelli A, Ubaldi N, Ubaldi FM, Rienzi L. Impact of maternal age on oocyte and embryo competence. Front Endocrinol. 2018;9:327.CrossRef
42.
Roque M, Lattes K, Serra S, Sola I, Geber S, Carreras R, et al. Fresh embryo transfer versus frozen embryo transfer in in vitro fertilization cycles: a systematic review and meta-analysis. Fertil Steril. 2013;99(1):156–62.PubMedCrossRef
43.
44.
Giampaoli S, Vannucchi S. Obesity and diabetes, a global problem: what does recent data tell us? Ig Sanita Pubbl. 2016;72(6):561–70.PubMed
45.
Organization for Economic Cooperation and Development. Obesity Update 2017. Paris: OECD; 2017.
46.
47.
48.
Gillett WR, Putt T, Farquhar CM. Prioritising for fertility treatments--the effect of excluding women with a high body mass index. BJOG. 2006;113(10):1218.PubMedCrossRef
49.
Zachariah M, Fleming R, Acharya U. Management of obese women in assisted conception units: A UK survey. Hum Fertil. 2006;9(2):101–5.CrossRef
50.
National Institute for Health and Clinical Excellence. Dietary interventions and physical activity interventions for weight management before, during and after pregnancy. London: NIH; 2010.
51.
Pandey S, Maheshwari A, Bhattacharya S. Should access to fertility treatment be determined by female body mass index? Hum Reprod. 2010;25(4):815–20.PubMedCrossRef
52.
Bhandari M, Lochner H, Tornetta P. Effect of continuous versus dichotomous outcome variables on study power when sample sizes of orthopaedic randomized trials are small. Arch Orthop Trauma Surg. 2002;122(2):96–8.PubMedCrossRef
53.
Lashen H, Fear K, Sturdee DW. Obesity is associated with increased risk of first trimester and recurrent miscarriage: matched casecontrol study. Hum Reprod. 2004;19(7):1644–6.PubMedCrossRef
54.
Brannian JD, Schmidt SM, Kreger DO, Hansen KA. Baseline non-fasting serum leptin concentration to body mass index ratio is predictive of IVF outcomes. Hum Reprod. 2001;16(9):1819.PubMedCrossRef
55.
Lin XH, Wang H, Wu DD, Ullah K, Yu TT, Ur Rahman T, et al. High Leptin level attenuates embryo development in overweight/obese infertile women by inhibiting proliferation and promotes apoptosis in granule cell. Horm Metab Res. 2017;49(7):534–41.PubMedCrossRef
Metadata
Title
Does body mass index impact assisted reproductive technology treatment outcomes in gestational carriers
Authors
Noga Fuchs Weizman
Miranda K. Defer
Janice Montbriand
Julia M. Pasquale
Adina Silver
Clifford L. Librach
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Reproductive Biology and Endocrinology / Issue 1/2020
Electronic ISSN: 1477-7827
DOI
https://doi.org/10.1186/s12958-020-00602-2

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