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Open Access 01-12-2019 | Review

Reproductive functions of Kisspeptin/KISS1R Systems in the Periphery

Authors: Yubin Cao, Zeping Li, Wenyu Jiang, Yan Ling, Haibin Kuang

Published in: Reproductive Biology and Endocrinology | Issue 1/2019

Abstract

Kisspeptin and its G protein-coupled receptor KISS1R play key roles in mammalian reproduction due to their involvement in the onset of puberty and control of the hypothalamic-pituitary-gonadal axis. However, recent studies have indicated a potential role of extra-hypothalamic kisspeptin in reproductive function. Here, we summarize recent advances in our understanding of the physiological significance of kisspeptin/KISS1R in the peripheral reproductive system (including the ovary, testis, uterus, and placenta) and the potential role of kisspeptin/KISS1R in reproductive diseases. A comprehensive understanding of the expression, function, and potential molecular mechanisms of kisspeptin/KISS1R in the peripheral reproductive system will contribute to the diagnosis, treatment and prevention of reproductive diseases.

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Title: Reproductive functions of Kisspeptin/KISS1R Systems in the Periphery
Authors: Yubin Cao
Zeping Li
Wenyu Jiang
Yan Ling
Haibin Kuang
Publication date: 01-12-2019
Publisher: BioMed Central
Published in: Reproductive Biology and Endocrinology / Issue 1/2019
Electronic ISSN: 1477-7827
DOI: https://doi.org/10.1186/s12958-019-0511-x

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Reproductive functions of Kisspeptin/KISS1R Systems in the Periphery

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