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Reproductive Biology and Endocrinology
Published in: Reproductive Biology and Endocrinology 1/2016

Open Access 01-12-2016 | Research

Which one has a better obstetric and perinatal outcome in singleton pregnancy, IVF/ICSI or FET?: a systematic review and meta-analysis

Authors: J. Zhao, B. Xu, Q. Zhang, Y. P. Li

Published in: Reproductive Biology and Endocrinology | Issue 1/2016

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Abstract

Background

The present study aims to compare which one has a better obstetric and perinatal outcome in singleton pregnancy, frozen embryo transfer (FET) or. in vitro fertilization treatment/intracytoplasmic sperm injection (IVF/ICSI)?

Methods

MEDLINE, Google Scholar and the Cochrane Library were searched for the obstetric and perinatal outcomes in singleton pregnancy after assisted reproductive technology (ART) from inception until July 2016. Clinical trials, which compared obstetric/perinatal outcomes in singleton pregnancy after FET and IVF/ICSI-ET, were included. The primary outcome was low birth weight, preterm birth, perinatal mortality, still birth, and cesarean section.

Results

Thirteen cohort studies with 126,911 women were included, of which 12, 11, 6, 6, 5 studies were used to analyze low birth weight, preterm birth, perinatal mortality, still birth, and cesarean section, respectively. IVF/ICSI is associated with a high risk of preterm birth (OR = 1.14, 95 % CI: 1.02, 1.28) and low birth rate (OR = 1.48, 95 % CI: 1.37, 1.60). There was no significant difference in the risk of the still birth (OR = 1.01, 95 % CI: 0.76, 1.35) and perinatal mortality (OR = 1.11, 95 % CI: 0.85, 1.46) between FET and IVF/ICSI. Singleton pregnancy after FET was associated with higher cesarean section rate compared with IVF/ICSI (OR = 0.85, 95 % CI: 0.80, 0.91).

Conclusions

Singleton pregnancy after FET seems to have a better perinatal outcome compared with that after IVF/ICSI. Further randomized controlled trials which adjust for a variety of meaningful confounders are needed in order to draw sound conclusions.
Appendix
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Literature
1.
Maheshwari A, Pandey S, Shetty A, Hamilton M, Bhattacharya S. Obstetric and perinatal outcomes in singleton pregnancies resulting from the transfer of frozen thawed versus fresh embryos generated through in vitro fertilization treatment: a systematic review and meta-analysis. Fertil Steril. 2012;98:368–77.CrossRefPubMed
2.
Talaulikar VS, Arulkumaran S. Maternal, perinatal and long-term outcomes after assisted reproductive techniques (ART): implications for clinical practice. Eur J Obstet Gynecol Reprod Biol. 2013;170:13–9.CrossRefPubMed
3.
4.
5.
Bloise E, Feuer SK, Rinaudo PF. Comparative intrauterine development and placental function of ART concept: implications for human reproductive medicine and animal breeding. Hum Reprod Update. 2014;20:822–39.CrossRefPubMedPubMedCentral
6.
Mainigi MA, Olalere D, Burd I, Sapienza C, Bartolomei M, Coutifaris C. Periimplantation hormonal milieu: elucidating mechanisms of abnormal placentation and fetal growth. Biol Reprod. 2014;90:1–9.CrossRef
7.
De Mouzon J, Goossens V, Bhattacharya S, Castilla JA, Ferraretti AP, Korsak V, et al. Assisted reproductive technology in Europe, 2006: results generated from European registers by ESHRE. Hum Reprod. 2010;25:1851–62.CrossRefPubMed
8.
Min JK, Hughes E, Young D, Gysler M, Hemmings R, Cheung AP, et al. Elective single embryo transfer following in vitro fertilization. J Obstet Gynaecol Can. 2010;32:363–77.CrossRefPubMed
9.
JOINT SOGC-CFAS. Guidelines for the number of embryos to transfer following in vitro fertilization No. 182, September 2006. Int J Gynaecol Obstet. 2008;102:203–16.CrossRef
10.
Wada I, Macnamee MC, Wick K, Bradfield JM, Brinsden PR. Birth characteristics and perinatal outcome of babies conceived from cryopreserved embryos. Hum Reprod. 1994;9:543–6.PubMed
11.
Wikland M, Hardarson T, Hillensjo T, Westin C, Westlander G, Wood M, et al. Obstetric outcomes after transfer of vitrified blastocysts. Hum Reprod. 2010;25:1699–707.CrossRefPubMed
12.
Aflatoonian A, Mansoori Moghaddam F, Mashayekhy M, Mohamadian F. Comparison of early pregnancy and neonatal outcomes after frozen and fresh embryo transfer in ART cycles. J Assist Reprod Genet. 2010;27:695–700.CrossRefPubMedPubMedCentral
13.
Wang YA, Sullivan EA, Black D, Dean J, Bryant J, Chapman M. Preterm birth and low birth weight after assisted reproductive technology-related pregnancy in Australia between 1996 and 2000. Fertil Steril. 2005;83:1650–8.CrossRefPubMed
14.
Belva F, Henriet S, van den Abbeel E, Camus M, Devroey P, van der Elst J, et al. Neonatal outcome of 937 children born after transfer of cryopreserved embryos obtained by ICSI and IVF and comparison with outcome data of fresh ICSI and IVF cycles. Hum Reprod. 2008;10:2227–38.CrossRef
15.
Wells G, SBOD. The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of non-randomised Studies in Meta-analysis. In: Proceedings or the Third Symposium on Systematic Reviews beyond the Basics. Improving Quality and Impact, Oxford: 3–5 July 2000.
16.
Ishihara O, Araki R, Kuwahara A, Itakura A, Saito H, Adamson GD. Impact of frozen-thawed single blastocyst transfer on maternal and neonatal outcome: an analysis of 277,042 single embryo transfer cycles from 2008 to 2010 in Japan. Fertil Steril. 2014;101:128–33.CrossRefPubMed
17.
Pinborg A, Loft A, Henningsen AA, Nyboe RS, Andersen A. Infant outcome of 957 singletons born after frozen embryo replacement: The Danish National Cohort Study 1995–2006. Fertil Steril. 2010;94:1320–7.CrossRefPubMed
18.
Wennerholm U-B, Henningsen A-KA, Romundstad LB, Bergh C, Pinborg A, Skjaerven R, et al. Perinatal outcomes of children born after frozen-thawed embryo transfer: a Nordic cohort study from the CoNARTaS group. Hum Reprod. 2013;28:2545–53.CrossRefPubMed
19.
Sazonova A, Kallen K, Thurin-Kjellberg A, Wennerholm U-B, Bergh C. Obstetric outcome in singletons after in vitro fertilization with cryopreserved/ thawed embryos. Hum Reprod. 2012;27:1343–50.CrossRefPubMed
20.
Pinborg A, Wennerholm UB, Romundstad LB, Loft A, Aittomaki K, Soderstrom-Anttila V, et al. Why do singletons conceived after assisted reproduction technology have adverse perinatal outcome? Systematic review and meta-analysis. Hum Reprod Update. 2013;19:87–104.CrossRefPubMed
21.
Evans J, Hannan NJ, Edgell TA, Vollenhoven BJ, Lutjen PJ, Osianlis T, et al. Fresh versus frozen embryo transfer: backing clinical decisions with scientific and clinical evidence. Hum Reprod Update. 2014;20:808–21.CrossRefPubMed
22.
Kansal Kalra S, Ratcliffe SJ, Milman L, Gracia CR, Coutifaris C, Barnhart KT. Perinatal morbidity after in vitro fertilization is lower with frozen embryo transfer. Fertil Steril. 2011;95:548–53.CrossRefPubMed
23.
Healy DL, Breheny S, Halliday J, Jaques A, Rushford D, Garrett C, et al. Prevalence and risk factors for obstetric haemorrhage in 6730 singleton births after assisted reproductive technology in Victoria. Australia Hum Reprod. 2010;25:265–74.CrossRefPubMed
24.
Amor DJ, Xu JX, Halliday JL, Francis I, Healy DL, Breheny S, et al. Pregnancies conceived using assisted reproductive technologies (ART) have low levels of pregnancy-associated plasma protein-A (PAPP-A) leading to a high rate of false-positive results in first trimester screening for Down syndrome. Hum Reprod. 2009;24:1330–8.CrossRefPubMed
25.
Shih W, Rushford DD, Bourne H, Garrett C, McBain JC, Healy DL, et al. Factors affecting low birth weight after assisted reproduction technology: difference between transfer of fresh and cryopreserved embryos suggests an adverse effect of oocyte collection. Hum Reprod. 2008;23:1644–53.CrossRefPubMed
Metadata
Title
Which one has a better obstetric and perinatal outcome in singleton pregnancy, IVF/ICSI or FET?: a systematic review and meta-analysis
Authors
J. Zhao
B. Xu
Q. Zhang
Y. P. Li
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Reproductive Biology and Endocrinology / Issue 1/2016
Electronic ISSN: 1477-7827
DOI
https://doi.org/10.1186/s12958-016-0188-3

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