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Reproductive Biology and Endocrinology
Published in: Reproductive Biology and Endocrinology 1/2016

Open Access 01-12-2016 | Review

Genetic, hormonal and metabolic aspects of PCOS: an update

Authors: V. De Leo, M. C. Musacchio, V. Cappelli, M. G. Massaro, G. Morgante, F. Petraglia

Published in: Reproductive Biology and Endocrinology | Issue 1/2016

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Abstract

Polycystic ovary syndrome (PCOS) is a complex endocrine disorder affecting 5–10 % of women of reproductive age. It generally manifests with oligo/anovulatory cycles, hirsutism and polycystic ovaries, together with a considerable prevalence of insulin resistance. Although the aetiology of the syndrome is not completely understood yet, PCOS is considered a multifactorial disorder with various genetic, endocrine and environmental abnormalities. Moreover, PCOS patients have a higher risk of metabolic and cardiovascular diseases and their related morbidity, if compared to the general population.
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Metadata
Title
Genetic, hormonal and metabolic aspects of PCOS: an update
Authors
V. De Leo
M. C. Musacchio
V. Cappelli
M. G. Massaro
G. Morgante
F. Petraglia
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Reproductive Biology and Endocrinology / Issue 1/2016
Electronic ISSN: 1477-7827
DOI
https://doi.org/10.1186/s12958-016-0173-x

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Reproductive Biology and Endocrinology 1/2016 Go to the issue

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