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Open Access 01-12-2015 | Research

The HDL receptor SR-BI is associated with human prostate cancer progression and plays a possible role in establishing androgen independence

Authors: David Schörghofer, Katharina Kinslechner, Andrea Preitschopf, Birgit Schütz, Clemens Röhrl, Markus Hengstschläger, Herbert Stangl, Mario Mikula

Published in: Reproductive Biology and Endocrinology | Issue 1/2015

Abstract

Background

Human prostate cancer represents one of the most frequently diagnosed cancers in men worldwide. Currently, diagnostic methods are insufficient to identify patients at risk for aggressive prostate cancer, which is essential for early treatment. Recent data indicate that elevated cholesterol levels in the plasma are a prerequisite for the progression of prostate cancer. Here, we analyzed clinical prostate cancer samples for the expression of receptors involved in cellular cholesterol uptake.

Methods

We screened mRNA microarray files of prostate cancer samples for alterations in the expression levels of cholesterol transporters. Furthermore, we performed immunohistochemistry analysis on human primary prostate cancer tissue sections derived from patients to investigate the correlation of SR-BI with clinicopathological parameters and the mTOR target pS6.

Results

In contrast to LDLR, we identified SR-BI mRNA and protein expression to be induced in high Gleason grade primary prostate cancers. Histologic analysis of prostate biopsies revealed that 53.6 % of all cancer samples and none of the non-cancer samples showed high SR-BI staining intensity. The disease-free survival time was reduced (P = 0.02) in patients expressing high intra-tumor levels of SR-BI. SR-BI mRNA correlated with HSD17B1 and HSD3B1 and SR-BI protein staining showed correlation with active ribosomal protein S6 (RS = 0.828, P < 0.00001).

Conclusions

We identified SR-BI to indicate human prostate cancer formation, suggesting that increased levels of SR-BI may be involved in the generation of a castration-resistant phenotype.

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Title: The HDL receptor SR-BI is associated with human prostate cancer progression and plays a possible role in establishing androgen independence
Authors: David Schörghofer
Katharina Kinslechner
Andrea Preitschopf
Birgit Schütz
Clemens Röhrl
Markus Hengstschläger
Herbert Stangl
Mario Mikula
Publication date: 01-12-2015
Publisher: BioMed Central
Published in: Reproductive Biology and Endocrinology / Issue 1/2015
Electronic ISSN: 1477-7827
DOI: https://doi.org/10.1186/s12958-015-0087-z

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

The HDL receptor SR-BI is associated with human prostate cancer progression and plays a possible role in establishing androgen independence

Abstract

Background

Methods

Results

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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