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Reproductive Biology and Endocrinology
Published in: Reproductive Biology and Endocrinology 1/2015

Open Access 01-12-2015 | Research

No association between polymorphisms in PTEN and primary ovarian insufficiency in a Han Chinese population

Authors: Weiwei Zou, Binbin Wang, Jing Wang, Zhiguo Zhang, Xiaofeng Xu, Beili Chen, Xu Ma, Yunxia Cao

Published in: Reproductive Biology and Endocrinology | Issue 1/2015

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Abstract

Background

The aim of our study was to investigate the possible relationship between polymorphisms in PTEN (the phosphatase and tensin homolog located on chromosome ten in humans) and POI (primary ovarian insufficiency) in Chinese women.

Methods

Seven tag SNPs (single nucleotide polymorphisms) - rs1234219, rs1903858, rs2299939, rs35352882, rs17107001, rs2299941 and rs12572106 - were chosen from the CHB (Han Chinese people in Beijing, China) HapMap database. MALDI-TOF-MS (matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry) was used to detect the genotype distribution of the seven SNPs among 148 POI patients and 230 controls.

Results

No statistically significant difference was found in an association analysis of the seven SNPs in the allele frequencies, genotype frequencies, or haplotype distributions.

Conclusions

In summary, this study explored the relationship between polymorphisms in PTEN and POI in a Han Chinese population and suggests that polymorphisms in PTEN may not be associated with a risk of POI.
Literature
1.
Welt CK. Primary ovarian insufficiency: a more accurate term for premature ovarian failure. Clin Endocrinol (Oxf). 2008;68:499–509.CrossRef
2.
Cordts EB, Christofolini DM, Dos Santos AA, Bianco B, Barbosa CP. Genetic aspects of premature ovarian failure: a literature review. Arch Gynecol Obstet. 2011;283:635–43.PubMedCrossRef
3.
Nelson LM. Clinical practice. Primary ovarian insufficiency. N Engl J Med. 2011;360:606–14.CrossRef
4.
McGee EA, Hsueh AJ. Initial and cyclic recruitment of ovarian follicles. Endocr Rev. 2000;21:200–14.PubMed
5.
Reddy P, Liu L, Adhikari D, Jagarlamudi K, Rajareddy S, Shen Y, et al. Oocyte-specific deletion of Pten causes premature activation of the primordial follicle pool. Science. 2000;319:611–3.CrossRef
6.
7.
Shen WH, Balajee AS, Wang J, Wu H, Eng C, Pandolfi PP, et al. Essential role for nuclear PTEN in maintaining chromosomal integrity. Cell. 2007;128:157–70.PubMedCrossRef
8.
Di Cristofano A, Pesce B, Cordon-Cardo C, Pandolfi PP. Pten is essential for embryonic development and tumour suppression. Nat Genet. 2007;19:348–55.
9.
Li J, Kawamura K, Cheng Y, Liu S, Klein C, Liu S, et al. Activation of dormant ovarian follicles to generate mature eggs. Proc Natl Acad Sci U S A. 2010;107:10280–4.PubMedCentralPubMedCrossRef
10.
11.
12.
Wandji SA, Srsen V, Voss AK, Eppig JJ, Fortune JE. Initiation in vitro of growth of bovine primordial follicles. Biol Reprod. 1996;55:942–8.PubMedCrossRef
13.
Reddy P, Zheng W, Liu K. Mechanisms maintaining the dormancy and survival of mammalian primordial follicles. Trends Endocrinol Metab. 2010;21:96–103.PubMedCrossRef
14.
Adhikari D, Liu K. Molecular mechanisms underlying the activation of mammalian primordial follicles. Endocr Rev. 2009;30:438–64.PubMedCrossRef
15.
John GB, Gallardo TD, Shirley LJ, Castrillon DH. Foxo3 is a PI3K-dependent molecular switch controlling the initiation of oocyte growth. Dev Biol. 2008;321:197–204.PubMedCentralPubMedCrossRef
16.
Jagarlamudi K, Liu L, Adhikari D, Reddy P, Idahl A, Ottander U, et al. Oocyte-specific deletion of Pten in mice reveals a stage-specific function of PTEN/PI3K signaling in oocytes in controlling follicular activation. PLoS One. 2009;4:e6186.PubMedCentralPubMedCrossRef
17.
Shimizu Y, Kimura F, Takebayashi K, Fujiwara M, Takakura K, Takahashi K. Mutational analysis of the PTEN gene in women with premature ovarian failure. Acta Obstet Gynecol Scand. 2009;88:824–5.PubMedCrossRef
18.
Zhao Z, Qin Y, Ma J, Zhao H, Li J, Wang L, et al. PTEN gene analysis in premature ovarian failure patients. Acta Obstet Gynecol Scand. 2011;90:678–9.PubMedCrossRef
Metadata
Title
No association between polymorphisms in PTEN and primary ovarian insufficiency in a Han Chinese population
Authors
Weiwei Zou
Binbin Wang
Jing Wang
Zhiguo Zhang
Xiaofeng Xu
Beili Chen
Xu Ma
Yunxia Cao
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Reproductive Biology and Endocrinology / Issue 1/2015
Electronic ISSN: 1477-7827
DOI
https://doi.org/10.1186/s12958-015-0057-5

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