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Published in: Health and Quality of Life Outcomes 1/2018

Open Access 01-12-2018 | Research

Vitamin D deficiency is associated with poorer satisfaction with diabetes-related treatment and quality of life in patients with type 2 diabetes: a cross-sectional study

Authors: Nuria Alcubierre, Esmeralda Castelblanco, Montserrat Martínez-Alonso, Minerva Granado-Casas, Aureli Esquerda, Alicia Traveset, Dolores Martinez-Gonzalez, Josep Franch-Nadal, Didac Mauricio

Published in: Health and Quality of Life Outcomes | Issue 1/2018

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Abstract

Background

In this cross-sectional study, we assessed the possible association of vitamin D deficiency with self-reported treatment satisfaction and health-related quality of life in patients with type 2 diabetes.

Methods

We performed a sub-analysis of a previous study and included a total of 292 type 2 diabetic patients. We evaluated treatment satisfaction and health-related quality of life through specific tools: the Diabetes Treatment Satisfaction Questionnaire and the Audit of Diabetes-Dependent Quality of Life. Vitamin D deficiency was defined as 25 (OH) D serum levels < 15 ng/mL.

Results

Multivariable linear regression models were used to estimate the relationship of vitamin D deficiency with both outcomes once adjusted for self-reported patient characteristics. Vitamin D deficiency was significantly associated with the final score of the Diabetes Treatment Satisfaction Questionnaire and the single “diabetes-specific quality of life” dimension of the Audit of Diabetes-Dependent Quality of Life (p = 0.0198 and p = 0.0070, respectively). However, lower concentrations of 25-OH vitamin D were not associated with the overall quality of life score or the perceived frequency of hyperglycaemia and hypoglycaemia.

Conclusions

Our study shows the association between vitamin D deficiency and both the self-reported diabetes treatment satisfaction and the diabetes-specific quality of life in patients with type 2 diabetes.
Literature
1.
2.
go back to reference Alcubierre N, Rubinat E, Traveset A, Martínez-Alonso M, Hernandez M, Jurjo C, et al. A prospective cross-sectional study on quality of life and treatment satisfaction in type 2 diabetic patients with retinopathy without other major late diabetic complications. Health Qual Life Outcomes. 2014;12:131.CrossRefPubMedPubMedCentral Alcubierre N, Rubinat E, Traveset A, Martínez-Alonso M, Hernandez M, Jurjo C, et al. A prospective cross-sectional study on quality of life and treatment satisfaction in type 2 diabetic patients with retinopathy without other major late diabetic complications. Health Qual Life Outcomes. 2014;12:131.CrossRefPubMedPubMedCentral
3.
go back to reference Biderman A, Noff E, Harris SB, Friedman N, Levy A. Treatment satisfaction of diabetic patients: what are the contributing factors? Fam Pract. 2009;26:102–8.CrossRefPubMed Biderman A, Noff E, Harris SB, Friedman N, Levy A. Treatment satisfaction of diabetic patients: what are the contributing factors? Fam Pract. 2009;26:102–8.CrossRefPubMed
4.
go back to reference Ahmadieh H, Azar ST, Najla L, Arabi A. Hypovitaminosis D in patients with type 2 diabetes mellitus: a relation to disease control and complications. ISRN Endocrinol. 2013;2013:641098.PubMedPubMedCentral Ahmadieh H, Azar ST, Najla L, Arabi A. Hypovitaminosis D in patients with type 2 diabetes mellitus: a relation to disease control and complications. ISRN Endocrinol. 2013;2013:641098.PubMedPubMedCentral
5.
go back to reference Dusso AS. Update on the biological role of the vitamin D endocrine system. Curr Vas Pharmacol. 2014;12(2):272–7.CrossRef Dusso AS. Update on the biological role of the vitamin D endocrine system. Curr Vas Pharmacol. 2014;12(2):272–7.CrossRef
6.
go back to reference Sung CC, Liao MT, Lu KC, Wu CC. Role of vitamin D in insulin resistance. J Biomed Biotechnol. 2012;2012:634.195. Sung CC, Liao MT, Lu KC, Wu CC. Role of vitamin D in insulin resistance. J Biomed Biotechnol. 2012;2012:634.195.
7.
go back to reference Muscogiuri G, Mitri J, Mathieu C, Badenhoop, K, Tamer G, Orio F, et al. Vitamin D as a potential contributor in endocrine health and disease. Eur J Endocrinol 2014 Sep; 171(3):R101–R110. Muscogiuri G, Mitri J, Mathieu C, Badenhoop, K, Tamer G, Orio F, et al. Vitamin D as a potential contributor in endocrine health and disease. Eur J Endocrinol 2014 Sep; 171(3):R101–R110.
8.
go back to reference Joergensen C, Gall MA, Schmedes A, Tarnow L, Parving HH, Rossing P. Vitamin D levels and mortality in type 2 diabetes. Diabetes Care. 2010;33(10):2238–43.CrossRefPubMedPubMedCentral Joergensen C, Gall MA, Schmedes A, Tarnow L, Parving HH, Rossing P. Vitamin D levels and mortality in type 2 diabetes. Diabetes Care. 2010;33(10):2238–43.CrossRefPubMedPubMedCentral
9.
go back to reference Alcubierre N, Valls J, Rubinat E, Cao G, Esquerda A, Traveset A, et al. Vitamin D deficiency is associated with the presence and severity of diabetic retinopathy in type 2 diabetes mellitus. Journal of Diabetes Research 2015. 2015;374:178. Alcubierre N, Valls J, Rubinat E, Cao G, Esquerda A, Traveset A, et al. Vitamin D deficiency is associated with the presence and severity of diabetic retinopathy in type 2 diabetes mellitus. Journal of Diabetes Research 2015. 2015;374:178.
10.
go back to reference Fernández-Juárez G, Luño J, Barrio V, de Vinuesa SG, Praga M, Goicoechea M, et al. 25(OH) vitamin D levels and renal disease progression in patients with type 2 diabetic nephropathy and blockade of the rennin-angiotensin system. Clin J Am Soc Nephrol. 2013;8:1870–6.CrossRefPubMedPubMedCentral Fernández-Juárez G, Luño J, Barrio V, de Vinuesa SG, Praga M, Goicoechea M, et al. 25(OH) vitamin D levels and renal disease progression in patients with type 2 diabetic nephropathy and blockade of the rennin-angiotensin system. Clin J Am Soc Nephrol. 2013;8:1870–6.CrossRefPubMedPubMedCentral
11.
go back to reference Anand S, Kaysen GA, Chertow GM, Johansen KL, Grimes B, Dalrymple LS, et al. Vitamin D deficiency, self-reported physical activity and health-related quality of life: the comprehensive Dialysis study. Nephrol Dial Transplant. 2011;26:3683–8.CrossRefPubMedPubMedCentral Anand S, Kaysen GA, Chertow GM, Johansen KL, Grimes B, Dalrymple LS, et al. Vitamin D deficiency, self-reported physical activity and health-related quality of life: the comprehensive Dialysis study. Nephrol Dial Transplant. 2011;26:3683–8.CrossRefPubMedPubMedCentral
12.
go back to reference Basaran S, Guzel R, Coskun-Benlidayi I, Guler-Uysal F. Vitamin D status: effects on quality of life in osteoporosis among Turkish women. Qual Life Res. 2007;16(9):1491.CrossRefPubMed Basaran S, Guzel R, Coskun-Benlidayi I, Guler-Uysal F. Vitamin D status: effects on quality of life in osteoporosis among Turkish women. Qual Life Res. 2007;16(9):1491.CrossRefPubMed
13.
go back to reference Ulitsky A, Ananthakrishnan AN, Skaros S, Zadvornova Y, Binion DG, Mazen I. Vitamin D deficiency in patients with inflammatory bowel disease: association with disease activity and quality of life. J Parenter Enter Nutr. 2011;35:308.CrossRef Ulitsky A, Ananthakrishnan AN, Skaros S, Zadvornova Y, Binion DG, Mazen I. Vitamin D deficiency in patients with inflammatory bowel disease: association with disease activity and quality of life. J Parenter Enter Nutr. 2011;35:308.CrossRef
14.
go back to reference Ohta H, Uemura Y, Nakamura T, Fukunaga M, Ohashi Y, Hosoi T, et al. Serum 25-hydroxyvitamin D level as an independent determinant of quality of life in osteoporosis with a high risk for fracture. Clin Ther. 2014;36(2):225–35.CrossRefPubMed Ohta H, Uemura Y, Nakamura T, Fukunaga M, Ohashi Y, Hosoi T, et al. Serum 25-hydroxyvitamin D level as an independent determinant of quality of life in osteoporosis with a high risk for fracture. Clin Ther. 2014;36(2):225–35.CrossRefPubMed
15.
go back to reference Hye-Jung K, Jee-Yon l, Tae-Jong K an Ji-Won L. Association between serum vitamin D status and health-related quality of life (HRQOL) in an older Korean population with radiographic knee osteoarthritis: data from the Korean national health and nutrition examination survey (2010-2011). Health Qual Life Outcomes 2015; 13:48. Hye-Jung K, Jee-Yon l, Tae-Jong K an Ji-Won L. Association between serum vitamin D status and health-related quality of life (HRQOL) in an older Korean population with radiographic knee osteoarthritis: data from the Korean national health and nutrition examination survey (2010-2011). Health Qual Life Outcomes 2015; 13:48.
16.
go back to reference Rafiq R, Swart KMA, van Schoor NM, Deeg DJ, Lips P, de Jongh RT. Associations of serum 25-hydroxyvitamin D concentrations with quality of life and self-rated health in an older population. J Clin Endocrinol Metab. 2014;99(9):3136–43.CrossRefPubMed Rafiq R, Swart KMA, van Schoor NM, Deeg DJ, Lips P, de Jongh RT. Associations of serum 25-hydroxyvitamin D concentrations with quality of life and self-rated health in an older population. J Clin Endocrinol Metab. 2014;99(9):3136–43.CrossRefPubMed
17.
go back to reference Chao YS, Ekwaru JP, Ohinmaa A, Griener G, Veugelers PJ. Vitamin D and health-related quality of life in a community sample of older Canadians. Qual Life Res. 2014;23:2569–75.CrossRefPubMedPubMedCentral Chao YS, Ekwaru JP, Ohinmaa A, Griener G, Veugelers PJ. Vitamin D and health-related quality of life in a community sample of older Canadians. Qual Life Res. 2014;23:2569–75.CrossRefPubMedPubMedCentral
18.
go back to reference Tepper S, Dabush Y, Shahar DR, Endevelt R, Geva D, Ish-Shalom S. Vitamin D status and quality of life in healthy male high-tech employees. Nutrients. 2016;8:366.CrossRefPubMedCentral Tepper S, Dabush Y, Shahar DR, Endevelt R, Geva D, Ish-Shalom S. Vitamin D status and quality of life in healthy male high-tech employees. Nutrients. 2016;8:366.CrossRefPubMedCentral
19.
go back to reference De Rui M, Toffanello ED, Veronese N, Zambon S, Bolzetta F, Sartori L, et al. Vitamin D deficiency and leisure time activities in the elderly: are all pastimes the same? PLoS One. 2014;9(4):e94805.CrossRefPubMedPubMedCentral De Rui M, Toffanello ED, Veronese N, Zambon S, Bolzetta F, Sartori L, et al. Vitamin D deficiency and leisure time activities in the elderly: are all pastimes the same? PLoS One. 2014;9(4):e94805.CrossRefPubMedPubMedCentral
20.
go back to reference Valderas JM, Alonso J. Patient reported outcome measures: a model-based classification system for research and clinical practice. Qual Life Res. 2008;17:1125–35.CrossRefPubMed Valderas JM, Alonso J. Patient reported outcome measures: a model-based classification system for research and clinical practice. Qual Life Res. 2008;17:1125–35.CrossRefPubMed
22.
go back to reference Westra S, Krul-Poel YH, van Wijland HJ, ter Wee MM, Stam F, Lips P, et al. Effect of vitamin D supplementation on health status in non-vitamin D deficient people with type 2 diabetes mellitus. Endocr Connect. 2016;5:61–9.CrossRefPubMedPubMedCentral Westra S, Krul-Poel YH, van Wijland HJ, ter Wee MM, Stam F, Lips P, et al. Effect of vitamin D supplementation on health status in non-vitamin D deficient people with type 2 diabetes mellitus. Endocr Connect. 2016;5:61–9.CrossRefPubMedPubMedCentral
24.
go back to reference Bradley C, Todd C, Gorton T, Symonds E, Martin A, Plowright R. The development of an individualised questionnaire measure of perceived impact of diabetes on quality of life: the ADDQoL. Qual Life Res. 1999;8(1–2):79–91.CrossRefPubMed Bradley C, Todd C, Gorton T, Symonds E, Martin A, Plowright R. The development of an individualised questionnaire measure of perceived impact of diabetes on quality of life: the ADDQoL. Qual Life Res. 1999;8(1–2):79–91.CrossRefPubMed
25.
go back to reference Bradley C, De Pablos-Velasco P, Parhofer KG, Eschwège E, Gönder-Frederick, et al. PANORAMA: a European study to evaluate quality of life and treatment satisfaction in patients with type 2 diabetes mellitus-study design. Prim Care Diabetes. 2011;5(4):231–9.CrossRefPubMed Bradley C, De Pablos-Velasco P, Parhofer KG, Eschwège E, Gönder-Frederick, et al. PANORAMA: a European study to evaluate quality of life and treatment satisfaction in patients with type 2 diabetes mellitus-study design. Prim Care Diabetes. 2011;5(4):231–9.CrossRefPubMed
26.
go back to reference De Pablos-Velasco P, Salguero-Chaves E, Maya-Poyo J, Derivas-Otero B, García-Sánchez R, Viguera-Esther P. Quality of life and satisfaction with treatment in subjects with type 2 diabetes: results in Spain of the PANORAMA study. Endocrinol Nutr. 2014;61(1):18–26.CrossRef De Pablos-Velasco P, Salguero-Chaves E, Maya-Poyo J, Derivas-Otero B, García-Sánchez R, Viguera-Esther P. Quality of life and satisfaction with treatment in subjects with type 2 diabetes: results in Spain of the PANORAMA study. Endocrinol Nutr. 2014;61(1):18–26.CrossRef
27.
go back to reference Bradley C: Diabetes treatment satisfaction questionnaire (DTSQ). In handbook of psychology and diabetes: a guide to psychological measurement in diabetes research and practice. Editated by Bradley C. New York: Harwood Academic Publishers; 1994. p 111–132. Bradley C: Diabetes treatment satisfaction questionnaire (DTSQ). In handbook of psychology and diabetes: a guide to psychological measurement in diabetes research and practice. Editated by Bradley C. New York: Harwood Academic Publishers; 1994. p 111–132.
28.
go back to reference Gomis R, Herrera-Pombo J, Calderón A, Rubio-Terrés C, Sarasa P. Validación del cuestionario “Diabetes treatment satisfaction questionnaire” (DTSQ) en la población española. Pharmacoeconomics Spanish Research Articles. 2006;3(1):7–18.CrossRef Gomis R, Herrera-Pombo J, Calderón A, Rubio-Terrés C, Sarasa P. Validación del cuestionario “Diabetes treatment satisfaction questionnaire” (DTSQ) en la población española. Pharmacoeconomics Spanish Research Articles. 2006;3(1):7–18.CrossRef
29.
go back to reference Bradley C, Gamsu DS. Guidelines for encouraging psychological well-being. Report of a working group of the World Health Organization Regional Office for Europe and International Diabetes Federation European Region St Vincent Declaration Action Programme for Diabetes Diabet Med. 1994;11(5):510–6. Bradley C, Gamsu DS. Guidelines for encouraging psychological well-being. Report of a working group of the World Health Organization Regional Office for Europe and International Diabetes Federation European Region St Vincent Declaration Action Programme for Diabetes Diabet Med. 1994;11(5):510–6.
30.
go back to reference Hoffmann MR, Senior PA, Mager DR. Vitamin D supplementation and health-related quality of life: a systematic review of the literature. J Acad Nutr Diet. 2015;115(3):406–18.CrossRefPubMed Hoffmann MR, Senior PA, Mager DR. Vitamin D supplementation and health-related quality of life: a systematic review of the literature. J Acad Nutr Diet. 2015;115(3):406–18.CrossRefPubMed
31.
go back to reference Mira JJ, Aranaz J. Patient satisfaction as an outcome measure in heathcare. Med Clin (Barc). 2010;114(3):26–33. Mira JJ, Aranaz J. Patient satisfaction as an outcome measure in heathcare. Med Clin (Barc). 2010;114(3):26–33.
32.
go back to reference Vinagre I, Mata-Cases M, Hermosilla E, Morros R, Fina F, Rosell M, et al. Control of Glycemia and cardiovascular risk factors in patients with type 2 diabetes in primary Care in Catalonia (Spain). Diabetes Care. 2012;35(4):774–9.CrossRefPubMedPubMedCentral Vinagre I, Mata-Cases M, Hermosilla E, Morros R, Fina F, Rosell M, et al. Control of Glycemia and cardiovascular risk factors in patients with type 2 diabetes in primary Care in Catalonia (Spain). Diabetes Care. 2012;35(4):774–9.CrossRefPubMedPubMedCentral
Metadata
Title
Vitamin D deficiency is associated with poorer satisfaction with diabetes-related treatment and quality of life in patients with type 2 diabetes: a cross-sectional study
Authors
Nuria Alcubierre
Esmeralda Castelblanco
Montserrat Martínez-Alonso
Minerva Granado-Casas
Aureli Esquerda
Alicia Traveset
Dolores Martinez-Gonzalez
Josep Franch-Nadal
Didac Mauricio
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Health and Quality of Life Outcomes / Issue 1/2018
Electronic ISSN: 1477-7525
DOI
https://doi.org/10.1186/s12955-018-0873-3

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