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Health and Quality of Life Outcomes
Published in: Health and Quality of Life Outcomes 1/2017

Open Access 01-01-2017 | Research

Measurement properties of the EQ-5D across four major geriatric conditions: Findings from TOPICS-MDS

Authors: Jennifer E. Lutomski, Paul F. M. Krabbe, Nienke Bleijenberg, Jeanett Blom, Gertrudis I. J. M. Kempen, Janet MacNeil-Vroomen, Maaike E. Muntinga, Ewout Steyerburg, Marcel G. M. Olde-Rikkert, René J. F. Melis, on behalf of TOPICS Consortium

Published in: Health and Quality of Life Outcomes | Issue 1/2017

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Abstract

Background

As populations age, chronic geriatric conditions linked to progressive organ failure jeopardize health-related quality of life (HRQoL). Thus, this research assessed the validity and applicability of the EQ-5D (a common HRQoL instrument) across four major chronic geriatric conditions: hearing issues, joint damage, urinary incontinence, or dizziness with falls.

Methods

The study sample comprised 25,637 community-dwelling persons aged 65 years and older residing in the Netherlands (Data source: TOPICS-MDS, www.​topics-mds.​eu). Floor and ceiling effects were examined. To assess convergent validity, random effects meta-correlations (Spearman’s rho) were derived between individual EQ-5D domains and related survey items. To further examine construct validity, the association between sociodemographic characteristics and EQ-5D summary scores were assessed using linear mixed models. Outcomes were compared to the overall study population as well as a ‘healthy’ subgroup reporting no major chronic conditions.

Results

Whereas ceiling effects were observed in the overall study population and the ‘healthy’ subgroup, such was not the case in the geriatric condition subgroups. The majority of hypotheses regarding correlations between survey items and sociodemographic associations were supported. EQ-5D summary scores were lower in respondents who were older, female, widowed/single, lower educated, and living alone. Increasing co-morbidity had a clear negative effect on EQ-5D scores.

Conclusion

This study supported the construct validity of the EQ-5D across four major geriatric conditions. For older persons who are generally healthy, i.e. reporting few to no chronic conditions, the EQ-5D confers poor discriminative ability due to ceiling effects. Although the overall dataset initially suggested poor discriminative ability for the EQ-5D, such was not the case within subgroups presenting with major geriatric conditions.
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Literature
1.
Steptoe A, Deaton A, Stone AA. Subjective wellbeing, health, and ageing. Lancet. 2015;385(9968):640–8.
2.
Coons SJ, Rao S, Keininger DL, Hays RD. A comparative review of generic quality-of-life instruments. Pharmacoeconomics. 2000;17:13–35.CrossRefPubMed
3.
Tamburini M. Health-related quality of life measures in cancer. Ann Oncol. 2001;12 Suppl 3:S7–10.CrossRefPubMed
4.
5.
Bharmal M, Thomas 3rd J. Comparing the EQ-5D and the SF-6D descriptive systems to assess their ceiling effects in the US general population. Value Health. 2006;9:262–71.CrossRefPubMed
6.
Hounsome N, Orrell M, Edwards RT. EQ-5D as a quality of life measure in people with dementia and their carers: evidence and key issues. Value Health. 2011;14:390–9.CrossRefPubMed
7.
Brazier J, Roberts J, Tsuchiya A, Busschbach J. A comparison of the EQ-5D and SF-6D across seven patient groups. Health Econ. 2004;13:873–84.CrossRefPubMed
8.
Tordrup D, Mossman J, Kanavos P. Responsiveness of the EQ-5D to clinical change: is the patient experience adequately represented? Int J Technol Assess Health Care. 2014;30:10–9.CrossRefPubMed
9.
Moller AH, Erntoft S, Vinding GR, Jemec GB. A systematic literature review to compare quality of life in psoriasis with other chronic diseases using EQ-5D-derived utility values. Patient Relat Outcome Meas. 2015;6:167–77.PubMedPubMedCentral
10.
Hunger M, Thorand B, Schunk M, Doring A, Menn P, Peters A, Holle R. Multimorbidity and health-related quality of life in the older population: results from the German KORA-age study. Health Qual Life Outcomes. 2011;9:53.CrossRefPubMedPubMedCentral
11.
12.
Grutters JP, Joore MA, van der Horst F, Verschuure H, Dreschler WA, Anteunis LJ. Choosing between measures: comparison of EQ-5D, HUI2 and HUI3 in persons with hearing complaints. Qual Life Res. 2007;16:1439–49.CrossRefPubMedPubMedCentral
13.
Streiner DL, Norman GR. Health measure scales: a pratical guide to their development and use. 4th ed. New York: Oxford University Press; 2008. 167–210; 247–276.CrossRef
14.
Inouye SK, Studenski S, Tinetti ME, Kuchel GA. Geriatric syndromes: clinical, research, and policy implications of a core geriatric concept. J Am Geriatr Soc. 2007;55:780–91.CrossRefPubMedPubMedCentral
15.
Lutomski JE, Baars MA, Schalk BW, Boter H, Buurman BM, den Elzen WP, Jansen AP, Kempen GI, Steunenberg B, Steyerberg EW, et al. The development of the older persons and informal caregivers survey minimum DataSet (TOPICS-MDS): a large-scale data sharing initiative. PLoS One. 2013;8:e81673.CrossRefPubMedPubMedCentral
16.
17.
Lamers LM, Stalmeier PFM, McDonnell J, Krabbe PFM, van Busschbach JJ. [Measuring the quality of life in cost-utility analyses: the Dutch EQ-5D tariff]. Ned Tijdschr Geneeskd. 2005;149:1574–8.PubMed
18.
19.
Katz S, Ford AB, Moskowitz RW, Jackson BA, Jaffe MW. Studies of illness in the aged. The index of Adl: a standardized measure of biological and psychosocial function. JAMA. 1963;185:914–9.CrossRefPubMed
20.
Weinberger M, Samsa GP, Schmader K, Greenberg SM, Carr DB, Wildman DS. Comparing proxy and patients’ perceptions of patients’ functional status: results from an outpatient geriatric clinic. J Am Geriatr Soc. 1992;40:585–8.CrossRefPubMed
21.
22.
Cantril H. The pattern of human concerns. New Brunswick: Rutgers University Press; 1965.
23.
Stewart LA, Tierney JF. To IPD or not to IPD? Advantages and disadvantages of systematic reviews using individual patient data. Eval Health Prof. 2002;25:76–97.CrossRefPubMed
24.
Terwee CB, Bot SD, de Boer MR, van der Windt DA, Knol DL, Dekker J, Bouter LM, de Vet HC. Quality criteria were proposed for measurement properties of health status questionnaires. J Clin Epidemiol. 2007;60:34–42.CrossRefPubMed
25.
26.
27.
Brazier J, Jones N, Kind P. Testing the validity of the Euroqol and comparing it with the SF-36 health survey questionnaire. Qual Life Res. 1993;2:169–80.CrossRefPubMed
28.
29.
Cherepanov D, Palta M, Fryback DG, Robert SA. Gender differences in health-related quality-of-life are partly explained by sociodemographic and socioeconomic variation between adult men and women in the US: evidence from four US nationally representative data sets. Qual Life Res. 2010;19:1115–24.CrossRefPubMedPubMedCentral
30.
Hawton A, Green C, Dickens AP, Richards SH, Taylor RS, Edwards R, Greaves CJ, Campbell JL. The impact of social isolation on the health status and health-related quality of life of older people. Qual Life Res. 2011;20:57–67.CrossRefPubMed
31.
Agborsangaya CB, Lau D, Lahtinen M, Cooke T, Johnson JA. Health-related quality of life and healthcare utilization in multimorbidity: results of a cross-sectional survey. Qual Life Res. 2013;22:791–9.CrossRefPubMed
32.
Mujica-Mota RE, Roberts M, Abel G, Elliott M, Lyratzopoulos G, Roland M, Campbell J. Common patterns of morbidity and multi-morbidity and their impact on health-related quality of life: evidence from a national survey. Qual Life Res. 2015;24:909–18.CrossRefPubMed
33.
Yang Y, Longworth L, Brazier J. An assessment of validity and responsiveness of generic measures of health-related quality of life in hearing impairment. Qual Life Res. 2013;22:2813–28.CrossRefPubMedPubMedCentral
34.
Kuthubutheen J, Mittmann N, Amoodi H, Qian W, Chen JM. The effect of different utility measures on the cost-effectiveness of bilateral cochlear implantation. Laryngoscope. 2015;125:442–7.CrossRefPubMed
35.
Kiely KM, Gopinath B, Mitchell P, Browning CJ, Anstey KJ. Evaluating a dichotomized measure of self-reported hearing loss against gold standard audiometry: prevalence estimates and age bias in a pooled national data set. J Aging Health. 2012;24:439–58.CrossRefPubMed
36.
37.
Branch LG, Walker LA, Wetle TT, DuBeau CE, Resnick NM. Urinary incontinence knowledge among community-dwelling people 65 years of age and older. J Am Geriatr Soc. 1994;42:1257–62.CrossRefPubMed
38.
Bird JC, Beynon GJ, Prevost AT, Baguley DM. An analysis of referral patterns for dizziness in the primary care setting. Br J Gen Pract. 1998;48:1828–32.PubMedPubMedCentral
39.
Baumeister H, Kriston L, Bengel J, Harter M. High agreement of self-report and physician-diagnosed somatic conditions yields limited bias in examining mental-physical comorbidity. J Clin Epidemiol. 2010;63:558–65.CrossRefPubMed
40.
Banerjee S. Multimorbidity-older adults need health care that can count past one. Lancet. 2015;385(9968):587–9.
Metadata
Title
Measurement properties of the EQ-5D across four major geriatric conditions: Findings from TOPICS-MDS
Authors
Jennifer E. Lutomski
Paul F. M. Krabbe
Nienke Bleijenberg
Jeanett Blom
Gertrudis I. J. M. Kempen
Janet MacNeil-Vroomen
Maaike E. Muntinga
Ewout Steyerburg
Marcel G. M. Olde-Rikkert
René J. F. Melis
on behalf of TOPICS Consortium
Publication date
01-01-2017
Publisher
BioMed Central
Published in
Health and Quality of Life Outcomes / Issue 1/2017
Electronic ISSN: 1477-7525
DOI
https://doi.org/10.1186/s12955-017-0616-x

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