Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Health and Quality of Life Outcomes
Published in: Health and Quality of Life Outcomes 1/2016

Open Access 01-12-2016 | Research

Health-related quality of life in patients with Barrett’s esophagus

Authors: Chi-Yang Chang, Lukas Jyuhn-Hsiarn Lee, Jung-Der Wang, Ching-Tai Lee, Chi-Ming Tai, Tao-Qian Tang, Jaw-Town Lin

Published in: Health and Quality of Life Outcomes | Issue 1/2016

Login to get access

Abstract

Background

Gastroesophageal reflux disease (GERD) has become a major health problem globally, affecting patients’ health-related quality of life (HRQOL). Barrett’s esophagus (BE) is a precancerous lesion associated with GERD. BE patients might not only suffer from HRQOL losses by GERD but also face psychological distress due to the increased risk of developing cancer. However, the majority of patients in Asia have shorter BE segment which is different from the West. This study aimed to determine whether the HRQOL in BE patients were worse than in healthy referents in Taiwan.

Methods

Patients who received referral esophagogastroduodenoscopy for various symptoms were evaluated for the existence of BE. Lesions were judged as endoscopically suspected esophageal metaplasia (ESEM) if they showed morphological resemblances to BE by endoscopy. The diagnosis of BE was confirmed by histology with intestinal metaplasia or gastric metaplasia based on the Montreal definition. The World Health Organization Quality of Life (WHOQOL-BREF) was administered to BE patients before treatment. For each BE patient, we selected 2 age-, sex-, educational background and municipality-matched healthy referents, sampled by simple randomization method from a national survey in Taiwan. Multiple linear regression models were constructed to control the potential confounders.

Results

A total of 84 patients diagnosed with BE were enrolled as BE group and then compared with 168 healthy referents. The BE group had significantly lower WHOQOL-BREF scores than those of healthy referents in the physical domain (P < 0.05) but higher scores in the environment domain (P < 0.05). In the physical domain, the BE group had significantly lower scores in various facets, including pain, discomfort, sleep and rest and dependence on medications or treatments. There was no significant difference in social and psychological domains between the BE group and healthy referents.

Conclusions

BE patients suffer from poor sleep and rest and high dependence on medications, which significantly reduce their quality of life. Individual facets of each domain warrants a better clinical healthcare to improve quality of life of BE patients.
Literature
1.
2.
El-Serag HB. Time trends of gastroesophageal reflux disease: a systematic review. Clin Gastroenterol Hepatol. 2007;5:17–26.CrossRefPubMed
3.
Chang CY, Lee YC, Lee CT, Tu CH, Hwang JC, Chiang H, Tai CM, Chiang TH, Wu MS, Lin JT. The application of Prague C and M criteria in the diagnosis of Barrett’s esophagus in an ethnic Chinese population. Am J Gastroenterol. 2009;104:13–20.CrossRefPubMed
4.
Lee YC, Yen AM, Tai JJ, Chang SH, Lin JT, Chiu HM, Wang HP, Wu MS, Chen TH. The effect of metabolic risk factors on the natural course of gastro-oesophageal reflux disease. Gut. 2009;58:174–81.CrossRefPubMed
5.
Kaplan-Machlis B, Spiegler GE, Revicki DA. Health-related quality of life in primary care patients with gastroesophageal reflux disease. Ann Pharmacother. 1999;33:1032–6.CrossRefPubMed
6.
Revicki DA, Wood M, Maton PN, Sorensen S. The impact of gastroesophageal reflux disease on health-related quality of life. Am J Med. 1998;104:252–8.CrossRefPubMed
7.
El-Dika S, Guyatt GH, Armstrong D, Degl'innocenti A, Wiklund I, Fallone CA, Tanser L, Veldhuyzen van Zanten S, Heels-Ansdell D, Wahlqvist P, et al. The impact of illness in patients with moderate to severe gastro-esophageal reflux disease. BMC Gastroenterol. 2005;5:23.CrossRefPubMedPubMedCentral
8.
Winters Jr C, Spurling TJ, Chobanian SJ, Curtis DJ, Esposito RL, Hacker 3rd JF, Johnson DA, Cruess DF, Cotelingam JD, Gurney MS, et al. Barrett’s esophagus. A prevalent, occult complication of gastroesophageal reflux disease. Gastroenterology. 1987;92:118–24.CrossRefPubMed
9.
Study protocol for the World Health Organization project to develop a Quality of Life assessment instrument (WHOQOL). Qual Life Res. 1993;2:153–9.
10.
Lieberman DA, Oehlke M, Helfand M. Risk factors for Barrett’s esophagus in community-based practice. GORGE consortium. Gastroenterology Outcomes Research Group in Endoscopy. Am J Gastroenterol. 1997;92:1293–7.PubMed
11.
Csendes A, Smok G, Burdiles P, Korn O, Gradiz M, Rojas J, Recio M. Prevalence of intestinal metaplasia according to the length of the specialized columnar epithelium lining the distal esophagus in patients with gastroesophageal reflux. Dis Esophagus. 2003;16:24–8.CrossRefPubMed
12.
Shaheen N, Ransohoff DF. Gastroesophageal reflux, barrett esophagus, and esophageal cancer: scientific review. JAMA. 2002;287:1972–81.CrossRefPubMed
13.
Mann NS, Tsai MF, Nair PK. Barrett’s esophagus in patients with symptomatic reflux esophagitis. Am J Gastroenterol. 1989;84:1494–6.PubMed
14.
Crockett SD, Lippmann QK, Dellon ES, Shaheen NJ. Health-related quality of life in patients with Barrett’s esophagus: a systematic review. Clin Gastroenterol Hepatol. 2009;7:613–23.CrossRefPubMedPubMedCentral
15.
Lippmann QK, Crockett SD, Dellon ES, Shaheen NJ. Quality of life in GERD and Barrett’s esophagus is related to gender and manifestation of disease. Am J Gastroenterol. 2009;104:2695–703.CrossRefPubMedPubMedCentral
16.
Kulig M, Leodolter A, Vieth M, Schulte E, Jaspersen D, Labenz J, Lind T, Meyer-Sabellek W, Malfertheiner P, Stolte M, Willich SN. Quality of life in relation to symptoms in patients with gastro-oesophageal reflux disease-- an analysis based on the ProGERD initiative. Aliment Pharmacol Ther. 2003;18:767–76.CrossRefPubMed
17.
Eloubeidi MA, Provenzale D. Health-related quality of life and severity of symptoms in patients with Barrett’s esophagus and gastroesophageal reflux disease patients without Barrett’s esophagus. Am J Gastroenterol. 2000;95:1881–7.CrossRefPubMed
18.
Gerson LB, Ullah N, Hastie T, Goldstein MK. Does cancer risk affect health-related quality of life in patients with Barrett’s esophagus? Gastrointest Endosc. 2007;65:16–25.CrossRefPubMed
19.
Fisher D, Jeffreys A, Bosworth H, Wang J, Lipscomb J, Provenzale D. Quality of life in patients with Barrett’s esophagus undergoing surveillance. Am J Gastroenterol. 2002;97:2193–200.CrossRefPubMed
20.
Lagergren J, Bergstrom R, Lindgren A, Nyren O. Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma. N Engl J Med. 1999;340:825–31.CrossRefPubMed
21.
Farrow DC, Vaughan TL, Sweeney C, Gammon MD, Chow WH, Risch HA, Stanford JL, Hansten PD, Mayne ST, Schoenberg JB, et al. Gastroesophageal reflux disease, use of H2 receptor antagonists, and risk of esophageal and gastric cancer. Cancer Causes Control. 2000;11:231–8.CrossRefPubMed
22.
Ye W, Chow WH, Lagergren J, Yin L, Nyren O. Risk of adenocarcinomas of the esophagus and gastric cardia in patients with gastroesophageal reflux diseases and after antireflux surgery. Gastroenterology. 2001;121:1286–93.CrossRefPubMed
23.
Barrett’s esophagus: epidemiological and clinical results of a multicentric survey. Gruppo Operativo per lo Studio delle Precancerosi dell’Esofago (GOSPE). Int J Cancer. 1991;48:364–8.
24.
Gerson LB, Shetler K, Triadafilopoulos G. Prevalence of Barrett’s esophagus in asymptomatic individuals. Gastroenterology. 2002;123:461–7.CrossRefPubMed
25.
Rex DK, Cummings OW, Shaw M, Cumings MD, Wong RK, Vasudeva RS, Dunne D, Rahmani EY, Helper DJ. Screening for Barrett’s esophagus in colonoscopy patients with and without heartburn. Gastroenterology. 2003;125:1670–7.CrossRefPubMed
26.
The World Health Organization Quality of Life Assessment (WHOQOL): development and general psychometric properties. Soc Sci Med. 1998;46:1569–85.
27.
Anderson RT, Aaronson NK, Bullinger M, McBee WL. A review of the progress towards developing health-related quality-of-life instruments for international clinical studies and outcomes research. Pharmacoeconomics. 1996;10:336–55.CrossRefPubMed
28.
Development of the World Health Organization WHOQOL-BREF quality of life assessment. The WHOQOL Group. Psychol Med. 1998;28:551–8.
29.
Yang SC, Kuo PW, Wang JD, Lin MI, Su S. Quality of life and its determinants of hemodialysis patients in Taiwan measured with WHOQOL-BREF(TW). Am J Kidney Dis. 2005;46:635–41.CrossRefPubMed
30.
Chang CY, Huang CK, Chang YY, Tai CM, Lin JT, Wang JD. Prospective study of health-related quality of life after Roux-en-Y bypass surgery for morbid obesity. Br J Surg. 2010;97:1541–6.CrossRefPubMed
31.
Yang CY, Chiou SL, Wang JD, Guo YL. Health related quality of life and polychlorinated biphenyls and dibenzofurans exposure: 30 years follow-up of Yucheng cohort. Environ Res. 2015;137:59–64.CrossRefPubMed
32.
Vakil N, van Zanten SV, Kahrilas P, Dent J, Jones R, Global Consensus G. The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol. 2006;101:1900–20. quiz 1943.CrossRefPubMed
33.
Lin SH. Field collection and completeness of data in the national health interview survey. NHIS Brief Commun. 2002;4:1–8.
34.
Liou HH, Chen RC, Chen CC, Chiu MJ, Chang YY, Wang JD. Health related quality of life in adult patients with epilepsy compared with a general reference population in Taiwan. Epilepsy Res. 2005;64:151–9.CrossRefPubMed
35.
Chang CY, Hung CK, Chang YY, Tai CM, Lin JT, Wang JD. Health-related quality of life in adult patients with morbid obesity coming for bariatric surgery. Obes Surg. 2010;20:1121–7.CrossRefPubMed
36.
Jamali R, Jamali A, Poorrahnama M, Omidi A, Jamali B, Moslemi N, Ansari R, Dolatshahi S, Ebrahimi Daryani N. Evaluation of health related quality of life in irritable bowel syndrome patients. Health Qual Life Outcomes. 2012;10:12.CrossRefPubMedPubMedCentral
37.
Lee LJ, Chung CW, Chang YY, Lee YC, Yang CH, Liou SH, Liu PH, Wang JD. Comparison of the quality of life between patients with non-small-cell lung cancer and healthy controls. Qual Life Res. 2011;20:415–23.CrossRefPubMed
38.
Yang SC, Lai WW, Hsiue TR, Su WC, Lin CK, Hwang JS, Wang JD. Health-related quality of life after first-line anti-cancer treatments for advanced non-small cell lung cancer in clinical practice. Qual Life Res. 2016;25:1441–9.CrossRefPubMed
39.
Goh SG, Rusli BN, Khalid BA. Development and validation of the Asian Diabetes Quality of Life (AsianDQOL) Questionnaire. Diabetes Res Clin Pract. 2015;108:489–98.CrossRefPubMed
40.
Chung WS, Lan YL, Yang MC. Psychometric testing of the short version of the world health organization quality of life (WHOQOL-BREF) questionnaire among pulmonary tuberculosis patients in Taiwan. BMC Public Health. 2012;12:630.CrossRefPubMedPubMedCentral
41.
Tabatabaeian M, Afshar H, Roohafza HR, Daghaghzadeh H, Feizi A, Sharbafchi MR, Tabatabaeian M, Naji F, Adibi P. Psychological status in Iranian patients with ulcerative colitis and its relation to disease activity and quality of life. J Res Med Sci. 2015;20:577–84.CrossRefPubMedPubMedCentral
42.
Jamali R, Raisi M, Matini M, Moravveji A, Omidi A, Amini J. Health related quality of life in irritable bowel syndrome patients, Kashan, Iran: A case control study. Adv Biol Res. 2015;4:75.
43.
Jamali R, Biglari M. The comparison of WHOQOL-BREF with disease specific heath related quality of life questionnaire in irritable bowel syndrome. Acta Med Iran. 2015;53:717–24.PubMed
44.
Chang CY, Huang CK, Chang YY, Tai CM, Lin JT, Wang JD. Cross-validation of the Taiwan version of the Moorehead-Ardelt Quality of Life Questionnaire II with WHOQOL and SF-36. Obes Surg. 2010;20:1568–74.CrossRefPubMed
45.
Chang KC, Wang JD, Tang HP, Cheng CM, Lin CY. Psychometric evaluation, using Rasch analysis, of the WHOQOL-BREF in heroin-dependent people undergoing methadone maintenance treatment: further item validation. Health Qual Life Outcomes. 2014;12:148.CrossRefPubMedPubMedCentral
46.
Hung MC, Lu WS, Chen SS, Hou WH, Hsieh CL, Wang JD. Validation of the EQ-5D in Patients with Traumatic Limb Injury. J Occup Rehabil. 2015;25:387–93.CrossRefPubMed
Metadata
Title
Health-related quality of life in patients with Barrett’s esophagus
Authors
Chi-Yang Chang
Lukas Jyuhn-Hsiarn Lee
Jung-Der Wang
Ching-Tai Lee
Chi-Ming Tai
Tao-Qian Tang
Jaw-Town Lin
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Health and Quality of Life Outcomes / Issue 1/2016
Electronic ISSN: 1477-7525
DOI
https://doi.org/10.1186/s12955-016-0551-2

Other articles of this Issue 1/2016

Health and Quality of Life Outcomes 1/2016 Go to the issue

Erratum

Erratum to: Metformin improved health-related quality of life in ethnic Chinese women with polycystic ovary syndrome

Review

Systematic review reveals lack of quality in reporting health-related quality of life in patients with gastroenteropancreatic neuroendocrine tumours

Review

Knowledge, attitudes, beliefs, values, preferences, and feasibility in relation to the use of injection safety devices in healthcare settings: a systematic review

Research

Validation of PRISM (Pictorial Representation of Illness and Self Measure) as a novel visual assessment tool for the burden of suffering in tinnitus patients

Short report

An analysis of the complementarity of ICECAP-A and EQ-5D-3 L in an adult population of patients with knee pain

Research

Measuring the impact of migraine for evaluating outcomes of preventive treatments for migraine headaches