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Clinical and Molecular Allergy

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Open Access 01-12-2018 | Case Report

Tryptase as a marker of severity of aortic valve stenosis

Authors: Laura M. Losappio, Corrado Mirone, Michel Chevallard, Laura Farioli, Fabrizio De Luca, Elide A. Pastorello

Published in: Clinical and Molecular Allergy | Issue 1/2018

Abstract

Background

Severe aortic valve stenosis is one of the most common cause of mortality in adult patients affected with metabolic syndrome, a condition associated with an active inflammatory process involving also mast cells and their mediators, in particular tryptase. The aim of this study was to characterize the possible long-term prognostic role of tryptase in severe aortic valve stenosis.

Case presentation

The baseline serum tryptase was measured in 5 consecutive patients admitted to our Hospital to undergo aortic valve replacement for severe acquired stenosis. Within 2 years after, the patients were evaluated for the occurrence of major cardiovascular events (MACE). The tryptase measurements were higher in patients experiencing MACE (10.9, 11.7 and 9.32 ng/ml) than in non-MACE ones (5.69 and 5.58 ng/ml).

Conclusions

In patients affected with severe aortic stenosis, baseline serum tryptase may predict occurence of MACE. Further studies are needed to demonstrate the long-term prognostic role of this biomarker.

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Title: Tryptase as a marker of severity of aortic valve stenosis
Authors: Laura M. Losappio
Corrado Mirone
Michel Chevallard
Laura Farioli
Fabrizio De Luca
Elide A. Pastorello
Publication date: 01-12-2018
Publisher: BioMed Central
Published in: Clinical and Molecular Allergy / Issue 1/2018
Electronic ISSN: 1476-7961
DOI: https://doi.org/10.1186/s12948-018-0095-6

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Tryptase as a marker of severity of aortic valve stenosis

Abstract

Background

Case presentation

Conclusions

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Case presentation

Conclusions

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