Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
Clinical and Molecular Allergy
Published in: Clinical and Molecular Allergy 1/2017

Open Access 01-12-2017 | Research

Effects of specific allergen immunotherapy on biological markers and clinical parameters in asthmatic children: a controlled-real life study

Authors: I. Djuric-Filipovic, Marco Caminati, D. Filipovic, C. Salvottini, Z. Zivkovic

Published in: Clinical and Molecular Allergy | Issue 1/2017

Login to get access

Abstract

Background

Allergen-specific immunotherapy (AIT) is the only treatment able to change the natural course of allergic diseases. We aimed at investigating the clinical efficacy of SLITOR (Serbian registered vaccine for sublingual allergen specific immunotherapy).

Methods

7–18 years old children with allergic asthma and rhinitis were enrolled and addressed to the active (AIT plus pharmacological treatment) or control (standard pharmacological treatment only) group. Clinical and medications scores, lung function and exhaled FeNO were measured at baseline and at every follow-up.

Results

There was a significant improvement in both nasal and asthma symptom scores as well as in medication score in SLIT group. SLIT showed an important influence on lung function and airway inflammation.

Conclusions

Our data showed that SLITOR was effective not only in terms of patient reported outcomes but an improvement of pulmonary function and decrease of lower airway inflammation were also observed.
Literature
1.
Gough H, Grabenhenrich L, Reich A, et al. Allergic multimorbidity of asthma, rhinitis and eczema over 20 years in the German birth cohort MAS. Pediatr Allergy Immunol. 2015;26:431–7.CrossRefPubMedPubMedCentral
2.
Caminati M, Duric-Filipovic I, Arasi S, Peroni DG, Zivkovic Z, Senna G. Respiratory allergies in childhood: recent advances and future challenges. Pediatr Allergy Immunol. 2015;26:702–10.CrossRefPubMed
3.
Alduraywish SA, Lodge CJ, Campbell B, et al. The march from early life food sensitization to allergic disease: a systematic review and meta-analyses of birth cohort studies. Allergy. 2015. doi:10.​1111/​all.​1278.PubMed
4.
Arasi S, Passalacqua G, Caminiti L, Crisafulli G, Fiamingo C, Pajno GB. Efficacy and safety of sublingual immunotherapy in children. Expert Rev Clin Immunol. 2016;12(1):49–56.CrossRefPubMed
5.
6.
Caminati M, Dama AR, Djuric I, Montagni M, Schiappoli M, Ridolo E, Senna G, Canonica GW. Incidence and risk factors for subcutaneous immunotherapy anaphylaxis: the optimization of safety. Expert Rev Clin Immunol. 2015;11(2):233–45.CrossRefPubMed
7.
Đurić-Filipović I, Caminati M, Kostić G, Filipović Đ, Živković Z. Allergen specific sublingual immunotherapy in children with asthma and allergic rhinitis. World J Pediatr. 2016;12(3):283–90.CrossRefPubMed
8.
Živković Z, Djurić-Filipović I, Živanović S. Current issues on sublingual allergen-specific immunotherapy in children with asthma and allergic rhinitis. Srp Arh Celok Lek. 2016;144(5–6):345–50.
9.
10.
11.
Bannier MA, van de Kant KD, Jobsis Q, Dompeling E. Biomarkers to predict asthma in wheezing preschool children. Clin Exp Allergy. 2015;45:1040–50.CrossRefPubMed
12.
Moschino L, Zanconato S, Bozzetto S, Baraldi E, Carraro S. Childhood asthma biomarkers: present knowledge and future steps. Paediatr Respir Rev. 2015;12:S1526–42.
13.
Payne DN, Adcock IM, Wilson NM, Oates T, Scallan M, Bush A. Relationship between exhaled nitric oxide and mucosal eosinophilic inflammation in children with difficult asthma, after treatment with oral prednisolone. Am J Respir Crit Care Med. 2001;164:1376–81.CrossRefPubMed
14.
American Thoracic Society, European Respiratory Society. ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide. Am J Respir Crit Care Med. 2005;171:912–30.CrossRef
15.
Dweik RA, Boggs PB, Erzurum SC, on behalf of the American Thoracic Society Committee on Interpretation of Exhaled Nitric Oxide Levels (FeNO) for Clinical Applications, et al. An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FeNO) for clinical applications. Am J Respir Crit Care Med. 2011;184:602–15.CrossRefPubMedPubMedCentral
16.
Cristescu SM, Mandon J, Harren FJ, Meriläinen P, Högman M. Methods of NO detection in exhaled breath. J Breath Res. 2013;7:017104.CrossRefPubMed
17.
Kovesi T, Kulka R, Dales R. Exhaled nitric oxide concentration is affected by age, height, and race in healthy 9- to 12-year-old children. Chest. 2008;133:169–75.CrossRefPubMed
18.
Tari MG, Mancino M, Monti G. Efficacy of sublingual immunotherapy in patients with rhinitis and asthma due to house dust mite. A double blind study. Allergol Immunopathol. 1990;18:277–84.
19.
Hirsch T, Sahn M, Leupold W. Double blind placebo controlled study of sublingual immunotherapy with house dust mite extracts in children. Pediatr Allergy Immunol. 1997;8(1):21–7.CrossRefPubMed
20.
Vourdas D, Syrigou E, Potamianou P, Carat F, Batard T. Double -blind, placebo-controlled evaluation of sublingual immunotherapy with standardized olivepollen extract in pediatric patients with allergic rhinoconjunctivitis and mild asthma due to olive pollen sensitization. Allergy. 1998;53:662–72.CrossRefPubMed
21.
La Rosa M, Ranno C, Andre´ C, Carat F, Tosca MA, Canonica GW. Double-blind placebo-controlled evaluation of sublingual swallow immunotherapy with standardized Parietaria judaica extract in children with allergic rhinoconjunctivitis. J Allergy Clin Immunol. 1999;104:425–32.CrossRefPubMed
22.
Pajno GB, Morabito L, Barberio G, Parmiani S. Clinical and immunologic effects of long-term sublingual immunotherapy in asthmatic children sensitized to mites: a double-blind, placebo-controlled study. Allergy. 2000;55:842–9.CrossRefPubMed
23.
Caffarelli C, Sensi LG, Marcucci F, Cavagni C. Preseasonal local allergoid immunotherapy to grass pollen in children: a double-blind, placebo-controlled, randomized trial. Allergy. 2000;55:1142–7.CrossRefPubMed
24.
Yuksel H, Tanac R, Gousseinov A, Demir E. Sublingual immunotherapy and influence on urinary leukotrienes in season al pediatric allergy. J Investig Allergol Clin Immunol. 1999;9:305–13.PubMed
25.
Bahceciler NN, Isik U, Barlan IB, Basaran MM. Efficacy of sublingual immunotherapy in children with asthma and rhinitis: a double-blind, placebo-controlled study. Pediatr Pulmonol. 2001;32:49–55.CrossRefPubMed
26.
Bufe A, Ziegler-Kirbach E, Stoeckmann E, Heidemann P, Gehlhar K, Holland-Letz T, et al. Efficacy of sublingual swallow immunotherapy in children with severe grass pollen allergic symptoms: a double-blind placebo-controlled study. Allergy. 2004;59:498–504.CrossRefPubMed
27.
Rolinck-Werninghaus C, Wolf H, Liebke C, Baars JC, Lange J, Kopp MV, et al. A pros pective, randomized, double-blind, placebo-controlled multi-centre study on the efficacy and safety of sublingual immunotherapy (SLIT) in children with seasonal allergic rhinoconjunctivitis to grass pollen. Allergy. 2004;59:1285–93.CrossRefPubMed
28.
Stelmach I, Kaczmarek-Woz´niak J, Majak P, Olszowiec-Chlebna M, Jerzynska J. Efficacy and safety of high-doses sublingual immunotherapy in ultra-rush scheme in children allergic to grass pollen. Clin Exp Allergy. 2009;39:401–8.CrossRefPubMed
29.
Penagos M, Compalati E, Tarantini F, Baena-Cagnani R, Huerta J, Passalacqua G, et al. Efficacy of sublingual immunotherapy in the treatment of allergic rhinitis in pediatric patients 3 to 18 years of age: a meta-analysis of randomized, placebo-controlled, double-blind trials. Ann Allergy Asthma Immunol. 2006;97:141–8.CrossRefPubMed
30.
Radulovic S, Wilson D, Calderon M, Durham S. Systematic reviews of sublingual immunotherapy (SLIT). Allergy. 2011;66:740–52.CrossRefPubMed
31.
Wilson DR, Torres LI, Durham SR. Sublingual immunotherapy for allergic rhinitis. Cochrane Database Syst Rev. 2003;2:CD002893.
32.
Calamita Z, Saconato H, Pelá AB, Atallah AN. Efficacy of sublingual immunotherapy in asthma: systematic review of randomized-clinical trials using the Cochrane Collaboration method. Allergy. 2006;10:1162–72.CrossRef
33.
Penagos M, Passalacqua G, Compalati E, Baena-Cagnani CE, Orozco S, Pedroza A, et al. Metaanalysis of the efficacy of sublingual immunotherapy in the treatment of allergic asthma in pediatric patients, 3 to 18 years of age. Chest. 2008;133:599–609.CrossRefPubMed
34.
Nelson H, Blaiss M, Nolte H, Wu¨rtz SØ, Andersen JS, Durham SR. Efficacy and safety of the SQ-standardized grass allergy immunotherapy tablet in mono- and polysensitized subjects. Allergy. 2013;68:252–5.CrossRefPubMed
35.
Malling HJ, Montagut A, Melac M, Patriarca G, Panzner P, Seberova E, et al. Efficacy and safety of 5-grass pollen sublingual immunotherapy tablets in patients with different clinical profiles of allergic rhinoconjunctivitis. Clin Exp Allergy. 2009;39(3):387–93.CrossRefPubMedPubMedCentral
36.
Marogna M, Spadolini I, Massolo A, Canonica GW, Passalacqua G. Long-lasting effects of sublingual immunotherapy according to its duration: a 15-year prospective study. J Allergy Clin Immunol. 2010;126(5):969–75.CrossRefPubMed
37.
Kharitonov SA, Yates D, Robbins RA, Logan-Sinclair R, Shinebourne E, Barnes PJ. Increased nitric oxide in exhaled air of asthmatic patients. Lancet. 1994;343:133–5.CrossRefPubMed
38.
Massaro AF, Mehta S, Lilly CM, Kobzik L, Reilly JJ, Drazen JM. Elevated nitric oxide concentrations in isolated lower airway gas of asthmatic subjects. Am J Respir Crit Care Med. 1996;153:1510–4.CrossRefPubMed
39.
de Arruda-Chaves E, De Conti D, Tebaldi T. Nitric oxide sera levels as an inflammatory marker in asthma. J Investig Allergol Clin Immunol. 2002;12(2):120–3.PubMed
40.
Hung CH, Lee MY, Tsai YG, Cheng SN, Yang KD. Hyposensitization therapy reduced exhaled nitric oxide in asthmatic children with corticosteroid dependency. Acta Paediatr Taiwan. 2004;45:89–93.PubMed
41.
Inci D, Altintas DU, Kendirli SG, Yilmaz M, Karakoc GB. The effect of specifi c immunotherapy on exhaled breath condensate nitrite levels. Allergy. 2006;61:899–900.CrossRefPubMed
Metadata
Title
Effects of specific allergen immunotherapy on biological markers and clinical parameters in asthmatic children: a controlled-real life study
Authors
I. Djuric-Filipovic
Marco Caminati
D. Filipovic
C. Salvottini
Z. Zivkovic
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Clinical and Molecular Allergy / Issue 1/2017
Electronic ISSN: 1476-7961
DOI
https://doi.org/10.1186/s12948-017-0064-5

Other articles of this Issue 1/2017

Clinical and Molecular Allergy 1/2017 Go to the issue

Case Report

Anticonvulsant hypersensitivity syndrome after phenytoin administration in an adolescent patient: a case report and review of literature

Case Report

Avoiding misdiagnosis in patients with dyspnea and wheezing: a case report illustrating the clinical implications of fixation error

Review

Hypersensitivity pneumonitis: a complex lung disease

Review

Hypersensitivity reactions due to black henna tattoos and their components: are the clinical pictures related to the immune pathomechanism?

Research

A survey on the perception of allergy specialists about the reimbursed grass pollen tablets for seasonal allergic rhinitis in Italy

Commentary

SANI-Severe Asthma Network in Italy: a way forward to monitor severe asthma