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Molecular Cancer
Published in: Molecular Cancer 1/2018

Open Access 01-12-2018 | Review

Multipotent mesenchymal stromal cells play critical roles in hepatocellular carcinoma initiation, progression and therapy

Authors: Zeli Yin, Keqiu Jiang, Rui Li, Chengyong Dong, Liming Wang

Published in: Molecular Cancer | Issue 1/2018

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Abstract

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, with high morbidity, relapse and mortality rates. Multipotent mesenchymal stromal cells (MSCs) can be recruited to and become integral components of the HCC microenvironment and can influence tumor progression. This review discusses MSC migration to liver fibrosis and the HCC microenvironment, MSC involvement in HCC initiation and progression and the widespread application of MSCs in HCC-targeted therapy, thus clarifying the critical roles of MSCs in HCC.
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Metadata
Title
Multipotent mesenchymal stromal cells play critical roles in hepatocellular carcinoma initiation, progression and therapy
Authors
Zeli Yin
Keqiu Jiang
Rui Li
Chengyong Dong
Liming Wang
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Molecular Cancer / Issue 1/2018
Electronic ISSN: 1476-4598
DOI
https://doi.org/10.1186/s12943-018-0926-6

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