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Molecular Cancer
Published in: Molecular Cancer 1/2016

Open Access 01-12-2016 | Letter to the Editor

Small non-coding RNA biomarkers in sputum for lung cancer diagnosis

Authors: Yun Su, Maria A. Guarnera, HongBin Fang, Feng Jiang

Published in: Molecular Cancer | Issue 1/2016

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Abstract

The early detection of lung cancer can reduce the mortality. However, there is no effective means in clinical settings for noninvasively detecting lung cancer. We previously developed 3 sputum miRNA biomarkers and 2 sputum small nucleolar RNA (snoRNA) biomarkers that can potentially be used for noninvasively diagnosing lung cancer. Here we evaluate the individual and combined applications of the two types of biomarkers in different sets of lung cancer patients and controls. Combined analysis of the miRNAs and snoRNAs has a synergistic effect with 89 % sensitivity and 89 % specificity, and may provide a useful tool for lung cancer early detection.
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Metadata
Title
Small non-coding RNA biomarkers in sputum for lung cancer diagnosis
Authors
Yun Su
Maria A. Guarnera
HongBin Fang
Feng Jiang
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Molecular Cancer / Issue 1/2016
Electronic ISSN: 1476-4598
DOI
https://doi.org/10.1186/s12943-016-0520-8

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