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Molecular Cancer
Published in: Molecular Cancer 1/2015

Open Access 01-12-2015 | Review

RUNX2 and the PI3K/AKT axis reciprocal activation as a driving force for tumor progression

Authors: Karine A. Cohen-Solal, Rajeev K. Boregowda, Ahmed Lasfar

Published in: Molecular Cancer | Issue 1/2015

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Abstract

From the first reported role of the transcription factor RUNX2 in osteoblast and chondrocyte differentiation and migration to its involvement in promigratory/proinvasive behavior of breast, prostate, and thyroid cancer cells, osteosarcoma, or melanoma cells, RUNX2 currently emerges as a key player in metastasis. In this review, we address the interaction of RUNX2 with the PI3K/AKT signaling pathway, one of the critical axes controlling cancer growth and metastasis. AKT, either by directly phosphorylating/activating RUNX2 or phosphorylating/inactivating regulators of RUNX2 stability or activity, contributes to RUNX2 transcriptional activity. Reciprocally, the activation of the PI3K/AKT pathway by RUNX2 regulation of its different components has been described in non-transformed and transformed cells. This mutual activation in the context of cancer cells exhibiting constitutive AKT activation and high levels of RUNX2 might constitute a major driving force in tumor progression and aggressiveness.
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Metadata
Title
RUNX2 and the PI3K/AKT axis reciprocal activation as a driving force for tumor progression
Authors
Karine A. Cohen-Solal
Rajeev K. Boregowda
Ahmed Lasfar
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Molecular Cancer / Issue 1/2015
Electronic ISSN: 1476-4598
DOI
https://doi.org/10.1186/s12943-015-0404-3

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