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Molecular Cancer
Published in: Molecular Cancer 1/2015

Open Access 01-12-2015 | Review

MicroRNA modulators of epigenetic regulation, the tumor microenvironment and the immune system in lung cancer

Authors: Anna Maria Rusek, Mohammed Abba, Andrzej Eljaszewicz, Marcin Moniuszko, Jacek Niklinski, Heike Allgayer

Published in: Molecular Cancer | Issue 1/2015

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Abstract

Cancer is an exceedingly complex disease that is orchestrated and driven by a combination of multiple aberrantly regulated processes. The nature and depth of involvement of individual events vary between cancer types, and in lung cancer, the deregulation of the epigenetic machinery, the tumor microenvironment and the immune system appear to be especially relevant. The contribution of microRNAs to carcinogenesis and cancer progression is well established with many reports and investigations describing the involvement of microRNAs in lung cancer, however most of these studies have concentrated on single microRNA-target relations and have not adequately addressed the complexity of their interactions. In this review, we focus, in part, on the role of microRNAs in the epigenetic regulation of lung cancer where they act as active molecules modulating enzymes that take part in methylation-mediated silencing and chromatin remodeling. Additionally, we highlight their contribution in controlling and modulating the tumor microenvironment and finally, we describe their role in the critical alteration of essential molecules that influence the immune system in lung cancer development and progression.
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Metadata
Title
MicroRNA modulators of epigenetic regulation, the tumor microenvironment and the immune system in lung cancer
Authors
Anna Maria Rusek
Mohammed Abba
Andrzej Eljaszewicz
Marcin Moniuszko
Jacek Niklinski
Heike Allgayer
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Molecular Cancer / Issue 1/2015
Electronic ISSN: 1476-4598
DOI
https://doi.org/10.1186/s12943-015-0302-8

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