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Cancer Cell International
Published in: Cancer Cell International 1/2019

Open Access 01-12-2019 | Cytostatic Therapy | Review

The diverse mechanisms and anticancer potential of naphthoquinones

Authors: Carolina Escardó Pereyra, Rafael Ferreira Dantas, Sabrina Baptista Ferreira, Luciano Pinho Gomes, Floriano Paes Silva-Jr

Published in: Cancer Cell International | Issue 1/2019

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Abstract

Cancer is one of the leading causes of death around the world and although the different clinical approaches have helped to increase survival rates, incidence is still high and so its mortality. Chemotherapy is the only approach which is systemic, reaching cancer cells in all body tissues and the search for new potent and selective drugs is still an attractive field within cancer research. Naphthoquinones, natural and synthetic, have garnered much attention in the scientific community due to their pharmacological properties, among them anticancer action, and potential therapeutic significance. Many mechanisms of action have been reported which also depend on structural differences among them. Here, we describe some of the most relevant mechanisms of action reported so far for naphthoquinones and highlight novel targets which are being described in the literature. Furthermore, we gather some of the most impressive efforts done by researchers to harness the anticancer properties of these compounds through specifically designed structural modifications.
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Metadata
Title
The diverse mechanisms and anticancer potential of naphthoquinones
Authors
Carolina Escardó Pereyra
Rafael Ferreira Dantas
Sabrina Baptista Ferreira
Luciano Pinho Gomes
Floriano Paes Silva-Jr
Publication date
01-12-2019
Publisher
BioMed Central
Published in
Cancer Cell International / Issue 1/2019
Electronic ISSN: 1475-2867
DOI
https://doi.org/10.1186/s12935-019-0925-8

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