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Cancer Cell International
Published in: Cancer Cell International 1/2019

Open Access 01-12-2019 | Gastric Cancer | Primary research

A new Schiff base coordinated copper(II) compound induces apoptosis and inhibits tumor growth in gastric cancer

Authors: Yan Xia, Xingkai Liu, Luping Zhang, Jinzhu Zhang, Chaoying Li, Nan Zhang, Hong Xu, Yan Li

Published in: Cancer Cell International | Issue 1/2019

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Abstract

Background

Gastric cancer, as a multifactorial disorders, shows cytological and architectural heterogeneity compared to other gastrointestinal cancers, making it therapeutically challenging. Cisplatin is generally used in clinic for gastric cancer treatment but with toxic side effects and develops resistance. Anti-tumor properties of copper and its coordinated compounds have been explored intensively in recent years.

Methods

In this study, we synthesized a novel Schiff base copper coordinated compound (SBCCC) and examined its antitumor effects in two gastric cancer cell lines SGC-7901 and BGC-823 as well as a mouse model of gastric cancer.

Results

The results show that SBCCC can significantly inhibit the proliferation of gastric cancer cells in a dose- and time-dependent manner. The IC50 of SBCCC in SGC-7901 and BGC-823 cells is 1 μM, which is much less than cisplatin’s IC50. SBCCC induces apoptosis and causes cell cycle arrest at the G1 phase. SBCCC induces apoptosis via multiple pathways including inhibition of NF-κB, ROS production and autophagy.

Conclusions

The synthesized SBCCC induced cancer cell death via inhibition of NF-κB, ROS production and autophagy. The multiple cell-killing mechanisms were important to overcome therapeutic failure because of multidrug-resistance of cancer cells. SBCCC, with a lower IC50 compared to cisplatin, could render it the potential to overcome the side-effect for clinical application.
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Metadata
Title
A new Schiff base coordinated copper(II) compound induces apoptosis and inhibits tumor growth in gastric cancer
Authors
Yan Xia
Xingkai Liu
Luping Zhang
Jinzhu Zhang
Chaoying Li
Nan Zhang
Hong Xu
Yan Li
Publication date
01-12-2019
Publisher
BioMed Central
Published in
Cancer Cell International / Issue 1/2019
Electronic ISSN: 1475-2867
DOI
https://doi.org/10.1186/s12935-019-0801-6

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