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Cancer Cell International
Published in: Cancer Cell International 1/2018

Open Access 01-12-2018 | Review

ZFAS1: a novel tumor-related long non-coding RNA

Authors: Dan Dong, Zhongyi Mu, Chenghai Zhao, Mingli Sun

Published in: Cancer Cell International | Issue 1/2018

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Abstract

Long non-coding RNAs (lncRNA) are classified as a kind of RNA, which are longer than 200 nucleotides in length and cannot be translated into proteins. Multiple studies have demonstrated that lncRNAs are involved in various cellular processes, including proliferation, differentiation, cell death, and metastasis. In addition, aberrant expression of lncRNAs has been discovered in human tumors, where they function as either oncogenes or tumor suppressor genes. Among numerous lncRNAs, we focus on ZNFX1 antisense RNA 1 (ZFAS1), a well-known lncRNA that is aberrant overexpression in various tumors, including melanoma, esophageal squamous cell carcinoma, non-small cell lung cancer, gastric cancer, colon cancer, and Hepatocellular carcinoma, in which it functions as oncogene. In contrast, ZFAS1 is downregulated in breast cancer, which may function as tumor suppressor gene. In this review, we provide an overview of current evidence concerning the role and potential clinical utilities of ZFAS1 in human cancers.
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Metadata
Title
ZFAS1: a novel tumor-related long non-coding RNA
Authors
Dan Dong
Zhongyi Mu
Chenghai Zhao
Mingli Sun
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Cancer Cell International / Issue 1/2018
Electronic ISSN: 1475-2867
DOI
https://doi.org/10.1186/s12935-018-0623-y

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