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Cancer Cell International
Published in: Cancer Cell International 1/2018

Open Access 01-12-2018 | Primary Research

Downregulation of microRNA-21 inhibited radiation-resistance of esophageal squamous cell carcinoma

Authors: Fang Li, Jia-Hua Lv, Long Liang, Jun-chao Wang, Chu-Rong Li, Lei Sun, Tao Li

Published in: Cancer Cell International | Issue 1/2018

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Abstract

Background

MicroRNA-21 (miR-21) was previously reported being dysregulated in many kinds of cancer including esophageal squamous cell carcinoma (ESCC). In the present study, we aimed to investigate the role of miR-21 in ESCC, especially in its effects on radiation-sensitivity of ESCC.

Methods

Expression of miR-21 was detected in 63 pairs ESCC tumor and adjacent non-tumoral tissues using qRT-PCR, correlation between miR-21 and clinicopathological feature of ESCC was analyzed. The role of miR-21 in the proliferation, cell cycle and apoptosis of ESCC cells during irradiation were studied.

Results

MicroRNA-21 expression was significantly increased in ESCC tumor tissues. Expression of miR-21 was positively associated with advanced clinical stage. Under irradiation, overexpression of miR-21 increased cell proliferation and cells in S phase, and inhibited cell apoptosis of ESCC cells. In contrast, knockdown of miR-21 had an opposite effect.

Conclusions

Downregulation of miR-21 inhibited the radiation-resistance of ESCC, whereas overexpression of miR-21 increased the radiation-resistance. MiR-21 is a potential novel target for developing specific treatment interventions in ESCC in future.
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Metadata
Title
Downregulation of microRNA-21 inhibited radiation-resistance of esophageal squamous cell carcinoma
Authors
Fang Li
Jia-Hua Lv
Long Liang
Jun-chao Wang
Chu-Rong Li
Lei Sun
Tao Li
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Cancer Cell International / Issue 1/2018
Electronic ISSN: 1475-2867
DOI
https://doi.org/10.1186/s12935-018-0502-6

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