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BMC Medicine
Published in: BMC Medicine 1/2022

Open Access 01-12-2022 | Heart Failure | Review

Diastolic dysfunction and sex-specific progression to HFpEF: current gaps in knowledge and future directions

Authors: A. M. L. N. van Ommen, E. Dal Canto, Maarten J. Cramer, F. H. Rutten, N. C. Onland-Moret, H. M. den Ruijter

Published in: BMC Medicine | Issue 1/2022

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Abstract

Diastolic dysfunction of the left ventricle (LVDD) is equally common in elderly women and men. LVDD is a condition that can remain latent for a long time but is also held responsible for elevated left ventricular filling pressures and high pulmonary pressures that may result in (exercise-induced) shortness of breath. This symptom is the hallmark of heart failure with preserved ejection fraction (HFpEF) which is predominantly found in women as compared to men within the HF spectrum. Given the mechanistic role of LVDD in the development of HFpEF, we review risk factors and mechanisms that may be responsible for this sex-specific progression of LVDD towards HFpEF from an epidemiological point-of-view and propose future research directions.
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Metadata
Title
Diastolic dysfunction and sex-specific progression to HFpEF: current gaps in knowledge and future directions
Authors
A. M. L. N. van Ommen
E. Dal Canto
Maarten J. Cramer
F. H. Rutten
N. C. Onland-Moret
H. M. den Ruijter
Publication date
01-12-2022
Publisher
BioMed Central
Keyword
Heart Failure
Published in
BMC Medicine / Issue 1/2022
Electronic ISSN: 1741-7015
DOI
https://doi.org/10.1186/s12916-022-02650-4

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