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Open Access 01-12-2022 | COVID-19 | Research article

Is living in a household with children associated with SARS-CoV-2 seropositivity in adults? Results from the Swiss national seroprevalence study Corona Immunitas

Authors: Jacob Blankenberger, Marco Kaufmann, Emiliano Albanese, Rebecca Amati, Daniela Anker, Anne-Linda Camerini, Patricia Chocano-Bedoya, Stéphane Cullati, Alexia Cusini, Jan Fehr, Erika Harju, Philipp Kohler, Susi Kriemler, Gisela Michel, Nicolas Rodondi, Pierre-Yves Rodondi, Alexandre Speierer, Stefano Tancredi, Milo A. Puhan, Christian R. Kahlert, on behalf of the Corona Immunitas Research Group

Published in: BMC Medicine | Issue 1/2022

Abstract

Background

We aimed to determine whether living in a household with children is associated with SARS-CoV-2 seropositivity in adults and investigated interacting factors that may influence this association.

Methods

SARS-CoV-2 serology testing was performed in randomly selected individuals from the general population between end of October 2020 and February 2021 in 11 cantons in Switzerland. Data on sociodemographic and household characteristics, employment status, and health-related history was collected using questionnaires. Multivariable logistic regression was used to examine the association of living with children <18 years of age (number, age group) and SARS-CoV-2 seropositivity. Further, we assessed the influence of reported non-household contacts, employment status, and gender.

Results

Of 2393 working age participants (18–64 years), 413 (17.2%) were seropositive. Our results suggest that living with children and SARS-CoV-2 seropositivity are likely to be associated (unadjusted odds ratio (OR) 1.22, 95% confidence interval [0.98–1.52], adjusted OR 1.25 [0.99–1.58]). A pattern of a positive association was also found for subgroups of children aged 0–11 years (OR 1.21 [0.90–1.60]) and 12–17 years (OR 1.14 [0.78–1.64]). Odds of seropositivity were higher with more children (OR 1.14 per additional child [1.02–1.27]). Men had higher risk of SARS-CoV-2 infection when living with children than women (interaction: OR 1.74 [1.10–2.76]).

Conclusions

In adults from the general population living with children seems associated with SARS-CoV-2 seropositivity. However, child-related infection risk is not the same for every subgroup and depends on factors like gender. Further factors determining child-related infection risk need to be identified and causal links investigated.

Trial registration

https://www.isrctn.com/ISRCTN18181860 .

Available only for authorised users

Viner RM, Mytton OT, Bonell C, Melendez-Torres GJ, Ward J, Hudson L, et al. Susceptibility to SARS-CoV-2 infection among children and adolescents compared with adults: a systematic review and meta-analysis [Internet]. JAMA Pediatr. 175:143–56 American Medical Association; 2021 [cited 2021 Apr 30]. Available from: https://jamanetwork.com/.

The role of children (≤12 years of age) and adolescents (13-17 years of age) in the SARS-CoV-2 pandemic: a rapid review – Swiss National COVID-19 Science Task Force [Internet]. [cited 2021 Sep 27]. Available from: https://sciencetaskforce.ch/en/policy-brief/the-role-of-children-and-adolescents-0-18-years-of-age-in-the-transmission-of-sars-cov-2-a-rapid-review-09-04-2021/

O’Driscoll M, Ribeiro Dos Santos G, Wang L, Cummings DAT, Azman AS, Paireau J, et al. Age-specific mortality and immunity patterns of SARS-CoV-2. Nature. 2021;590(7844):140–5. [cited 2021 Aug 30];Available from. https://doi.org/10.1038/s41586-020-2918-0.CrossRefPubMed

Radtke T, Ulyte A, Puhan MA, Kriemler S. Long-term symptoms after SARS-CoV-2 infection in children and adolescents [Internet]. JAMA. 2021;326:869–71 [cited 2021 Sep 27]. Available from: https://pubmed.ncbi.nlm.nih.gov/34264266/.CrossRef

Miller F, Nguyen V, Navaratnam A, Shrotri M, Kovar J, Hayward AC, et al. Prevalence of persistent symptoms in children during the COVID-19 pandemic: evidence from a household cohort study in England and Wales. medRxiv. 2021 2021.05.28.21257602. [cited 2021 Sep 27];Available from. https://doi.org/10.1101/2021.05.28.21257602.

Molteni E, Sudre CH, Canas LS, Bhopal SS, Hughes RC, Antonelli M, et al. Illness duration and symptom profile in symptomatic UK school-aged children tested for SARS-CoV-2. Lancet Child Adolesc Health. 2021;5(10):708–18 Oct [cited 2021 Sep 27];Available from: www.thelancet.com/child-adolescent.CrossRef

Curmei M, Ilyas A, Evans O, Steinhardt J. Estimating household transmission of SARS-CoV-2. Available from: https://doi.org/10.1101/2020.05.23.20111559

Lewis NM, Chu VT, Ye D, Conners EE, Gharpure R, Laws RL, et al. Household transmission of severe acute respiratory syndrome coronavirus-2 in the United States. Clin Infect Dis. 2020; Aug 16 [cited 2021 Apr 30]; Available from: https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciaa1166/5893024.

Madewell ZJ, Yang Y, Longini IM, Halloran ME, Dean NE. Household transmission of SARS-CoV-2. JAMA Network Open. 2020;3(12):e2031756 14 [cited 2021 Jan 11];Available from: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2774102.CrossRef

10.

Spielberger BD, Goerne T, Geweniger A, Henneke P, Elling R. Intra-household and close-contact SARS-CoV-2 transmission among children – a systematic review. Front Pediatr. 2021;9:95.CrossRef

11.

Forbes H, Morton CE, Bacon S, McDonald HI, Minassian C, Brown JP, et al. Association between living with children and outcomes from covid-19: OpenSAFELY cohort study of 12 million adults in England. BMJ. 2021;372. [cited 2021 May 3]Available from:. https://doi.org/10.1136/bmj.n628.

12.

Husby A, Corn G, Grove KT. SARS-CoV-2 infection in households with and without young children: nationwide cohort study. medRxiv. 2021:2021.02.28.21250921. [cited 2021 May 3]. Available from. https://doi.org/10.1101/2021.02.28.21250921.

13.

Carrat F, de Lamballerie X, Rahib D, Blanché H, Lapidus N, Artaud F, et al. Antibody status and cumulative incidence of SARS-CoV-2 infection among adults in three regions of France following the first lockdown and associated risk factors: a multicohort study. Int J Epidemiol. 2021;2021:1–15 19 [cited 2021 Sep 15]. Available from: https://academic.oup.com/ije/advance-article/doi/10.1093/ije/dyab110/6323645.

14.

Galmiche S, Charmet T, Schaeffer L, Paireau J, Grant R, Chény O, et al. Exposures associated with SARS-CoV-2 infection in France: a nationwide online case-control study. Lancet Regional Health. 2021;7:100148 Aug [cited 2021 Sep 27]Available from: https://pubmed.ncbi.nlm.nih.gov/34124709/.CrossRef

15.

Wood R, Thomson E, Galbraith R, Gribben C, Caldwell D, Bishop J, et al. Sharing a household with children and risk of COVID-19: a study of over 300 000 adults living in healthcare worker households in Scotland. Arch Dis Childhood. 2021;0:1–6 18 [cited 2021 May 3]. Available from: http://adc.bmj.com/.

16.

Kahlert CR, Persi R, Güsewell S, Egger T, Leal-Neto OB, Sumer J, et al. Non-occupational and occupational factors associated with specific SARS-CoV-2 antibodies among hospital workers – a multicentre cross-sectional study. Clin Microbiol Infect. 2021;27(9):1336–44[cited 2021 Sep 13]. Available from. https://doi.org/10.1016/j.cmi.2021.05.0141198-743X/.CrossRefPubMedPubMedCentral

17.

Murhekar MV, Clapham H. COVID-19 serosurveys for public health decision making. Lancet Global Health. 2021;9:e559–60 Elsevier Ltd; [cited 2021 Jul 8]. Available from: www.thelancet.com/lancetgh.CrossRef

18.

Buonsenso D, Zampino G, Valentini P. Novel coronavirus disease 2019 infection in children: the dark side of a worldwide outbreak. Front Pediatr. 2020;8:215 Apr 30 [cited 2021 Jun 15]Available from: https://www.frontiersin.org/article/10.3389/fped.2020.00215/full.CrossRef

19.

West EA, Anker D, Amati R, Richard A, Wisniak A, Butty A, et al. Corona Immunitas: study protocol of a nationwide program of SARS-CoV-2 seroprevalence and seroepidemiologic studies in Switzerland. Int J Public Health. 2020;65(9):1529–48 1 [cited 2021 Jan 22]. Available from: https://pubmed.ncbi.nlm.nih.gov/33098441/.CrossRef

20.

Horby PW, Laurie KL, Cowling BJ, Engelhardt OG, Sturm-Ramirez K, Sanchez JL, et al. CONSISE statement on the reporting of seroepidemiologic studies for influenza (ROSES-I statement): an extension of the STROBE statement. Influenza Other Respir Virus. 2017;11(1):2–14 1 [cited 2021 Nov 23]. Available from: https://onlinelibrary.wiley.com/doi/10.1111/irv.12411.CrossRef

21.

COVID-⁠19 Switzerland | Coronavirus | Dashboard [Internet]. [cited 2021 Nov 28]. Available from: https://www.covid19.admin.ch/en/epidemiologic/virus-variants

22.

Fenwick C, Croxatto A, Coste AT, Pojer F, André C, Pellaton C, et al. Changes in SARS-CoV-2 spike versus nucleoprotein antibody responses impact the estimates of infections in population-based seroprevalence studies. J Virol. 2020;95(3):1828–48 3 [cited 2021 May 18]. Available from: http://jvi.asm.org/.

23.

Venables WN, Ripley BD. Modern applied statistics with S [Internet]. Fourth. Springer: New York; 2002. Available from: https://www.stats.ox.ac.uk/pub/MASS4/CrossRef

24.

Wickham H, Averick M, Bryan J, Chang W, McGowan L, François R, et al. Welcome to the tidyverse. J Open Source Software. 2019;4(43):1686.CrossRef

25.

Xie Y. knitr: a general-purpose tool for dynamic report generation in R [Internet]. Documentation. 2012;8:1–12 Available from: http://cloud.github.com/downloads/yihui/knitr/knitr-manual.pdf%5Cnpapers3://publication/uuid/50886732-8AFE-4961-8CDD-186D699DFB3A.

26.

Yoshida K, Bartel A. Create “Table 1” to describe baseline characteristics with or without propensity score weights [R package tableone version 0.13.0] [Internet]. 2021. Available from: https://cran.r-project.org/package=tableone

27.

Fleischer NL, Diez Roux A, v. Using directed acyclic graphs to guide analyses of neighbourhood health effects: an introduction. J Epidemiol Comm Health. 2008;62(9):842–6 Sep [cited 2022 Mar 1]. Available from: https://pubmed.ncbi.nlm.nih.gov/18701738/.CrossRef

28.

Lipsky AM, Greenland S. Causal directed acyclic graphs. JAMA [Internet]. 2022; Feb 28 [cited 2022 Mar 1]; Available from: https://jamanetwork.com/journals/jama/fullarticle/2789646.

29.

Rothman KJ, Greenland S, Lash TL. Modern epidemiology [Internet]. Wolters Kluwer Health/Lippincott Williams \& Wilkins; 2015. Available from: https://books.google.ch/books?id=MSTgnQAACAAJ

30.

Galmiche S, Charmet T, Schaeffer L, Paireau J, Grant R, Chény O, et al. Exposures associated with SARS-CoV-2 infection in France: a nationwide online case-control study. Lancet Regional Health Eur. 2021;7:100148 Aug 1 [cited 2021 Jun 26]. Available from: https://linkinghub.elsevier.com/retrieve/pii/S2666776221001253.CrossRef

31.

Sherman A, Reuben J, David N, Quasie-Woode DP, Gunn JK, Nielsen CF, et al. SARS-CoV-2 seroprevalence survey among district residents presenting for serologic testing at three community-based test sites — Washington, DC, July–August, 2020. medRxiv. 2021:2021.02.15.21251764. Feb 18 [cited 2021 Jun 26]. Available from. https://doi.org/10.1101/2021.02.15.21251764.

32.

Bi Q, Lessler J, Eckerle I, Lauer SA, Kaiser L, Vuilleumier N, et al. Insights into household transmission of SARS-CoV-2 from a population-based serological survey. Nat Commu. 2021;12(1):12. [cited 2021 Nov 28]. Available from. https://doi.org/10.1038/s41467-021-23733-5.CrossRef

33.

del Boca D, Oggero N, Profeta P, Cristina Rossi M, Alberto C. Did COVID-19 affect the division of labor within the household? Evidence from two waves of the pandemic in Italy 1; 2021.

34.

Grundy E, Tomassini C. Fertility history and health in later life: a record linkage study in England and Wales. Soc Sci Med. 2005;61(1):217–28 [cited 2021 Nov 24]. Available from: https://pubmed.ncbi.nlm.nih.gov/15847974/.CrossRef

35.

Grundy E, Kravdal O. Reproductive history and mortality in late middle age among Norwegian men and women. Am J Epidemiol. 2007;167(3):271–9 27 [cited 2021 Nov 24]. Available from: https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwm295.CrossRef

36.

Jaffe DH, Neumark YD, Eisenbach Z, Manor O. Parity-related mortality: shape of association among middle-aged and elderly men and women. Eur J Epidemiol. 2009;24(1):9–16 13 [cited 2021 Nov 24]. Available from: https://link.springer.com/article/10.1007/s10654-008-9310-y.CrossRef

37.

Li F, Li YY, Liu MJ, Fang LQ, Dean NE, Wong GWK, et al. Household transmission of SARS-CoV-2 and risk factors for susceptibility and infectivity in Wuhan: a retrospective observational study. Lancet Infect Dis. 2021;0(0) [cited 2021 Jan 27]. Available from. https://doi.org/10.1016/S1473-3099.

38.

Park Y, Choe Y, Park O, Park SY, Kim YM, Kim J, et al. Contact tracing during coronavirus disease outbreak, South Korea, 2020. Emerg Infect Dis. 2020;26(10) [cited 2021 May 3]. Available from. https://doi.org/10.3201/eid2610.201315.

39.

Dong Y, Dong Y, Mo X, Hu Y, Qi X, Jiang F, et al. Epidemiology of COVID-19 among children in China. Pediatrics. 2020;145:20200702. [cited 2021 Jan 3]. Available from. https://doi.org/10.1542/peds.2020-0702.CrossRef

40.

Castagnoli R, Votto M, Licari A, Brambilla I, Bruno R, Perlini S, et al. Severe Acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children and adolescents: a systematic review. JAMA Pediatr. 2020;174:882–9 [cited 2021 Jan 25]. p. Available from: https://jamanetwork.com/.CrossRef

41.

Hoang A, Chorath K, Moreira A, Evans M, Burmeister-Morton F, Burmeister F, et al. COVID-19 in 7780 pediatric patients: a systematic review. EClinicalMedicine. 2020;24. [cited 2021 Jan 25]. Available from. https://doi.org/10.1016/j.eclinm.2020.100433.

42.

Ulyte A, Radtke T, Abela IA, Haile SR, Berger C, Huber M, et al. Clustering and longitudinal change in SARS-CoV-2 seroprevalence in school children in the canton of Zurich, Switzerland: prospective cohort study of 55 schools. BMJ. 2021;372:n616. Mar 17 [cited 2021 Mar 21]. Available from:. https://doi.org/10.1136/bmj.n616.CrossRefPubMed

43.

Paul LA, Daneman N, Schwartz KL, Science M, Brown KA, Whelan M, et al. Association of age and pediatric household transmission of SARS-CoV-2 Infection. JAMA Pediatr. 2021; [cited 2021 Sep 13]; Available from: https://jamanetwork.com/.

44.

Mossong J, Hens N, Jit M, Beutels P, Auranen K, Mikolajczyk R, et al. Social contacts and mixing patterns relevant to the spread of infectious diseases. Riley S, editor. PLoS Med. 2008;5(3):e74. 25 [cited 2021 May 3]. Available from. https://doi.org/10.1371/journal.pmed.0050074.CrossRefPubMedPubMedCentral

45.

Soriano-Arandes A, Gatell A, Serrano P, Biosca M, Campillo F, Capdevila R, et al. Household SARS-CoV-2 transmission and children: a network prospective study. Clin Infect Dis. 2021 Mar 12 [cited 2021 Jun 25]; Available from:. https://doi.org/10.1093/cid/ciab228/6168547.

46.

Telle K, Jørgensen SB, Hart R, Greve-Isdahl M, Kacelnik O. Secondary attack rates of COVID-19 in Norwegian families: a nation-wide register-based study. Eur J Epidemiol. 2021;1:3. May 25 [cited 2021 Jun 26]. Available from. https://doi.org/10.1007/s10654-021-00760-6.CrossRef

47.

Thelwall S, Zaidi A, Nsonwu O, Rice W, Chudasama D, Lamagni T, et al. The role of multi-generational household clusters in COVID-19 in England. medRxiv. 2021:2021.11.22.21266540 [cited 2021 Nov 28]. Available from: https://orcid.org/0000-0002-6420-2539.

48.

Zhu Y, Bloxham CJ, Hulme KD, Sinclair JE, Tong ZWM, Steele LE, et al. A meta-analysis on the role of children in severe acute respiratory syndrome coronavirus 2 in household transmission clusters. Clin Infect Dis. 2020 Dec 6 [cited 2021 Apr 26]; Available from:. https://doi.org/10.1093/cid/ciaa1825/6024998.

49.

Zimmermann P, Curtis N. Why is COVID-19 less severe in children? A review of the proposed mechanisms underlying the age-related difference in severity of SARS-CoV-2 infections [Internet]. Arch Dis Childhood. 2020;106:429–39 [cited 2021 May 25]. Available from: http://adc.bmj.com/.CrossRef

50.

Ng KW, Faulkner N, Cornish GH, Rosa A, Harvey R, Hussain S, et al. Preexisting and de novo humoral immunity to SARS-CoV-2 in humans. Science (1979). 2020;370(6522):1339–43 11 [cited 2021 May 3]. Available from: http://science.sciencemag.org/.

51.

Mutambudzi M, Niedwiedz C, Macdonald EB, Leyland A, Mair F, Anderson J, et al. Occupation and risk of severe COVID-19: prospective cohort study of 120 075 UK Biobank participants. Occup Environ Med. 2021;78(5):307–14 1 [cited 2021 Jun 26]. Available from: http://oem.bmj.com/.CrossRef

52.

Piccoli L, Ferrari P, Piumatti G, Jovic S, Rodriguez BF, Mele F, et al. Risk assessment and seroprevalence of SARS-CoV-2 infection in healthcare workers of COVID-19 and non-COVID-19 hospitals in Southern Switzerland. Lancet Regional Health Eur. 2021;1:–100013. Feb 1 [cited 2021 Nov 24]. Available from. https://doi.org/10.1016/j.lanepe.2020.100013.

53.

Chu VT, Yousaf AR, Chang K, Schwartz NG, McDaniel CJ, Lee SH, et al. Household transmission of SARS-CoV-2 from children and adolescents. New Engl J Med. 2021;385(10):954–6. 2 [cited 2021 Sep 13]. Available from. https://doi.org/10.1056/NEJMc2031915.CrossRefPubMed

54.

Allen H, Vusirikala A, Flannagan J, Twohig KA, Zaidi A, Chudasama D, et al. Household transmission of COVID-19 cases associated with SARS-CoV-2 delta variant (B.1.617.2): national case-control study. Lancet Regional Health Eur. 2021:100252 [cited 2021 Nov 28]. Available from: https://linkinghub.elsevier.com/retrieve/pii/S2666776221002386.

55.

Jalali N, Brustad HK, Frigessi A, MacDonald E, Meijerink H, Feruglio S, et al. Increased household transmission and immune escape of the SARS-CoV-2 Omicron variant compared to the Delta variant: evidence from Norwegian contact tracing and vaccination data. medRxiv. 2022:2022.02.07.22270437. [cited 2022 Mar 2]. Available from. https://doi.org/10.1101/2022.02.07.22270437.

56.

Nordström P, Ballin M, Nordström A. Association between risk of COVID-19 infection in nonimmune individuals and COVID-19 immunity in their family members. JAMA Int Med. 2021; Oct 11 [cited 2021 Oct 19]; Available from: https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2785141.

Title: Is living in a household with children associated with SARS-CoV-2 seropositivity in adults? Results from the Swiss national seroprevalence study Corona Immunitas
Authors: Jacob Blankenberger
Marco Kaufmann
Emiliano Albanese
Rebecca Amati
Daniela Anker
Anne-Linda Camerini
Patricia Chocano-Bedoya
Stéphane Cullati
Alexia Cusini
Jan Fehr
Erika Harju
Philipp Kohler
Susi Kriemler
Gisela Michel
Nicolas Rodondi
Pierre-Yves Rodondi
Alexandre Speierer
Stefano Tancredi
Milo A. Puhan
Christian R. Kahlert
on behalf of the Corona Immunitas Research Group
Publication date: 01-12-2022
Publisher: BioMed Central
Keywords: COVID-19
SARS-CoV-2
COVID-19
Published in: BMC Medicine / Issue 1/2022
Electronic ISSN: 1741-7015
DOI: https://doi.org/10.1186/s12916-022-02431-z

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Is living in a household with children associated with SARS-CoV-2 seropositivity in adults? Results from the Swiss national seroprevalence study Corona Immunitas

Abstract

Background

Methods

Results

Conclusions

Trial registration

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

Trial registration

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