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BMC Medicine
Published in: BMC Medicine 1/2022

01-12-2022 | Kidney Cancer | Research article

The role of diet in renal cell carcinoma incidence: an umbrella review of meta-analyses of observational studies

Authors: Zhanchen Liao, Zhitao Fang, Siqi Gou, Yong Luo, Yiqi Liu, Zhun He, Xin Li, Yansong Peng, Zheng Fu, Dongjin Li, Haiyun Chen, Zhigang Luo

Published in: BMC Medicine | Issue 1/2022

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Abstract

Background

Evidence associating diet with the incidence of renal cell carcinoma (RCC) is inconclusive. We aimed to summarize evidence associating dietary factors with RCC incidence and assess the strength and validity of this evidence.

Methods

We conducted an umbrella review of systematic reviews or meta-analyses (SRoMAs) that assessed the association between diet and RCC incidence. Through April 2021, PubMed, Web of Science, Embase, The Cochrane Library, Scopus, and WCRF were searched. Two independent reviewers selected studies, extracted data, and appraised the quality of SRoMAs. According to credibility assessment criteria, evidence can be divided into five categories: convincing (class I), highly suggestive (class II), suggestive (class III), weak (class IV), and nonsignificant (class V).

Results

Twenty-nine meta-analyses were obtained after screening. After excluding 7 overlapping meta-analyses, 22 meta-analyses including 502 individual studies and 64 summary hazard ratios for RCC incidence were included: dietary patterns or dietary quality indices (n = 6), foods (n = 13), beverages (n = 4), alcohol (n = 7), macronutrients (n =15), and micronutrients (n =19). No meta-analyses had high methodological quality. Five meta-analyses exhibited small study effects; one meta-analysis showed evidence of excess significance bias. No dietary factors showed convincing or highly suggestive evidence of association with RCC in the overall analysis. Two protective factors had suggestive evidence (vegetables (0.74, 95% confidence interval 0.63 to 0.86) and vitamin C (0.77, 0.66 to 0.90)) in overall analysis. One protective factor had convincing evidence (moderate drinking (0.77, 0.70 to 0.84)) in Europe and North America and one protective factor had highly suggestive evidence (cruciferous vegetables (0.78, 0.70 to 0.86)) in North America.

Conclusions

Although many meta-analyses have assessed associations between dietary factors and RCC, no high-quality evidence exists (classes I and II) in the overall analysis. Increased intake of vegetables and vitamin C is negatively associated with RCC risk. Moderate drinking might be beneficial for Europeans and North Americans, and cruciferous vegetables might be beneficial to North Americans, but the results should be interpreted with caution. More researches are needed in the future.

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Appendix
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Literature
1.
Capitanio U, Bensalah K, Bex A, Boorjian SA, Bray F, Coleman J, et al. Epidemiology of renal cell carcinoma. Eur Urol. 2019;75(1):74–84.PubMedCrossRef
2.
Ferlay J, Colombet M, Soerjomataram I, Dyba T, Randi G, Bettio M, et al. Cancer incidence and mortality patterns in Europe: estimates for 40 countries and 25 major cancers in 2018. Eur J Cancer. 2018;103:356–87.PubMedCrossRef
3.
Motzer RJ, Agarwal N, Beard C, Bolger GB, Boston B, Carducci MA, et al. NCCN clinical practice guidelines in oncology: kidney cancer. J Natl Compr Canc Netw. 2009;7(6):618–30.PubMedCrossRef
4.
5.
Islami F, Ward EM, Sung H, Cronin KA, Tangka FKL, Sherman RL, et al. Annual report to the nation on the status of cancer, part 1: national cancer statistics. J Natl Cancer Inst. 2021.
6.
Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–49.PubMedCrossRef
7.
Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer Statistics, 2021. CA Cancer J Clin. 2021;71(1):7–33.PubMedCrossRef
8.
Maroun R, Fleury L, Nachbaur G, Maunoury F, Vanhille JL, Durand-Zaleski I. Real-world costs and outcomes in metastatic renal cell carcinoma patients treated with targeted therapies: a cohort study from the French health insurance database. Curr Med Res Opin. 2017;33(10):1755–62.PubMedCrossRef
9.
Tahbaz R, Schmid M, Merseburger AS. Prevention of kidney cancer incidence and recurrence: lifestyle, medication and nutrition. Curr Opin Urol. 2018;28(1):62–79.PubMedCrossRef
10.
Schouten LJ, van Dijk BA, Oosterwijk E, van Engeland M. Hulsbergen-van de Kaa CA, Kiemeney LA, et al. Alcohol consumption and mutations or promoter hypermethylation of the von Hippel-Lindau gene in renal cell carcinoma. Cancer Epidemiol Biomarkers Prev. 2008;17(12):3543–50.PubMedCrossRef
11.
Karami S, Brennan P, Navratilova M, Mates D, Zaridze D, Janout V, et al. Vitamin D pathway genes, diet, and risk of renal cell carcinoma. Int J Endocrinol. 2010;2010:879362.PubMedCrossRef
12.
Rhee J, Loftfield E. Freedman ND. Sinha R, Purdue MP. Coffee consumption and risk of renal cell carcinoma in the NIH-AARP Diet and Health Study. Int J Epidemiol: Liao LM; 2021.
13.
van de Pol JAA, George L, van den Brandt PA, Baldewijns M, Schouten LJ. Etiologic heterogeneity of clear-cell and papillary renal cell carcinoma in the Netherlands Cohort Study. Int J Cancer. 2021;148(1):67–76.PubMedCrossRef
14.
Daniel CR, Park Y, Chow WH, Graubard BI, Hollenbeck AR, Sinha R. Intake of fiber and fiber-rich plant foods is associated with a lower risk of renal cell carcinoma in a large US cohort. Am J Clin Nutr. 2013;97(5):1036–43.PubMedPubMedCentralCrossRef
15.
Faramawi MF, Johnson E, Fry MW, Sall M, Zhou Y. Consumption of different types of meat and the risk of renal cancer: meta-analysis of case-control studies. Cancer Causes Control. 2007;18(2):125–33.PubMedCrossRef
16.
Lee JE, Spiegelman D, Hunter DJ, Albanes D, Bernstein L, van den Brandt PA, et al. Fat, protein, and meat consumption and renal cell cancer risk: a pooled analysis of 13 prospective studies. J Natl Cancer Inst. 2008;100(23):1695–706.PubMedPubMedCentralCrossRef
17.
Zhang S, Wang Q, He J. Intake of red and processed meat and risk of renal cell carcinoma: a meta-analysis of observational studies. Oncotarget. 2017;8(44):77942–56.PubMedPubMedCentralCrossRef
18.
Alexander DD, Cushing CA. Quantitative assessment of red meat or processed meat consumption and kidney cancer. Cancer Detect Prev. 2009;32(5-6):340–51.PubMedCrossRef
19.
Ioannidis JP. Why most discovered true associations are inflated. Epidemiology. 2008;19(5):640–8.PubMedCrossRef
20.
21.
Dwan K, Gamble C, Williamson PR, Kirkham JJ. Systematic review of the empirical evidence of study publication bias and outcome reporting bias - an updated review. PLoS One. 2013;8(7):e66844.PubMedPubMedCentralCrossRef
22.
Boffetta P, McLaughlin JK, La Vecchia C, Tarone RE, Lipworth L, Blot WJ. False-positive results in cancer epidemiology: a plea for epistemological modesty. J Natl Cancer Inst. 2008;100(14):988–95.PubMedPubMedCentralCrossRef
23.
Radua J, Ramella-Cravaro V, Ioannidis JPA, Reichenberg A, Phiphopthatsanee N, Amir T, et al. What causes psychosis? An umbrella review of risk and protective factors. World Psychiatry. 2018;17(1):49–66.PubMedPubMedCentralCrossRef
24.
Howes OD, Whitehurst T, Shatalina E, Townsend L, Onwordi EC, Mak TLA, et al. The clinical significance of duration of untreated psychosis: an umbrella review and random-effects meta-analysis. World Psychiatry. 2021;20(1):75–95.PubMedPubMedCentralCrossRef
25.
Belbasis L, Bellou V, Evangelou E, Ioannidis JP, Tzoulaki I. Environmental risk factors and multiple sclerosis: an umbrella review of systematic reviews and meta-analyses. Lancet Neurol. 2015;14(3):263–73.PubMedCrossRef
26.
Okoth K, Chandan JS, Marshall T, Thangaratinam S, Thomas GN, Nirantharakumar K, et al. Association between the reproductive health of young women and cardiovascular disease in later life: umbrella review. Bmj. 2020;371:m3502.PubMedPubMedCentralCrossRef
27.
Li X, Meng X, Timofeeva M, Tzoulaki I, Tsilidis KK, Ioannidis JP, et al. Serum uric acid levels and multiple health outcomes: umbrella review of evidence from observational studies, randomised controlled trials, and Mendelian randomisation studies. Bmj. 2017;357:j2376.PubMedPubMedCentralCrossRef
28.
Neuenschwander M, Ballon A, Weber KS, Norat T, Aune D, Schwingshackl L, et al. Role of diet in type 2 diabetes incidence: umbrella review of meta-analyses of prospective observational studies. Bmj. 2019;366:l2368.PubMedPubMedCentralCrossRef
29.
Kyrgiou M, Kalliala I, Markozannes G, Gunter MJ, Paraskevaidis E, Gabra H, et al. Adiposity and cancer at major anatomical sites: umbrella review of the literature. Bmj. 2017;356:j477.PubMedPubMedCentralCrossRef
30.
Kalliala I, Markozannes G, Gunter MJ, Paraskevaidis E, Gabra H, Mitra A, et al. Obesity and gynaecological and obstetric conditions: umbrella review of the literature. Bmj. 2017;359:j4511.PubMedPubMedCentralCrossRef
31.
Ioannidis JP. Integration of evidence from multiple meta-analyses: a primer on umbrella reviews, treatment networks and multiple treatments meta-analyses. Cmaj. 2009;181(8):488–93.PubMedPubMedCentralCrossRef
32.
Markozannes G, Tzoulaki I, Karli D, Evangelou E, Ntzani E, Gunter MJ, et al. Diet, body size, physical activity and risk of prostate cancer: an umbrella review of the evidence. Eur J Cancer. 2016;69:61–9.PubMedCrossRef
33.
Aromataris E, Fernandez R, Godfrey CM, Holly C, Khalil H, Tungpunkom P. Summarizing systematic reviews: methodological development, conduct and reporting of an umbrella review approach. Int J Evid Based Healthc. 2015;13(3):132–40.PubMedCrossRef
34.
Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. Bmj. 2021;372:n71.PubMedPubMedCentralCrossRef
35.
Aromataris E, Fernandez R, Godfrey C, Holly C, Khalil H, Tungpunkom P. Methodology for jbi umbrella reviews. The Joanna Briggs Institute Reviewers Manual 2014: Joanna Briggs Institute; 2014. p. 5-34.
36.
Shea BJ, Reeves BC, Wells G, Thuku M, Hamel C, Moran J, et al. AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both. Bmj. 2017;358:j4008.PubMedPubMedCentralCrossRef
37.
AMSTAR. Assessing the methodological quality of systematic reviews. [Available from: https:/ /amstar.ca/Amstar_Checklist.php].
38.
Lorenz RC, Matthias K, Pieper D, Wegewitz U, Morche J, Nocon M, et al. A psychometric study found AMSTAR 2 to be a valid and moderately reliable appraisal tool. J Clin Epidemiol. 2019;114:133–40.PubMedCrossRef
39.
Créquit P, Trinquart L, Yavchitz A, Ravaud P. Wasted research when systematic reviews fail to provide a complete and up-to-date evidence synthesis: the example of lung cancer. BMC Med. 2016;14:8.PubMedPubMedCentralCrossRef
40.
Elliott JH, Synnot A, Turner T, Simmonds M, Akl EA, McDonald S, et al. Living systematic review: 1. Introduction-the why, what, when, and how. J Clin Epidemiol. 2017;91:23–30.PubMedCrossRef
41.
Garner P, Hopewell S, Chandler J, MacLehose H, Schünemann HJ, Akl EA, et al. When and how to update systematic reviews: consensus and checklist. Bmj. 2016;354:i3507.PubMedPubMedCentralCrossRef
42.
Shojania KG, Sampson M, Ansari MT, Ji J, Doucette S, Moher D. How quickly do systematic reviews go out of date? A survival analysis. Ann Intern Med. 2007;147(4):224–33.PubMedCrossRef
43.
Pieper D, Antoine SL, Mathes T, Neugebauer EA, Eikermann M. Systematic review finds overlapping reviews were not mentioned in every other overview. J Clin Epidemiol. 2014;67(4):368–75.PubMedCrossRef
44.
Bougioukas KI, Liakos A, Tsapas A, Ntzani E, Haidich AB. Preferred reporting items for overviews of systematic reviews including harms checklist: a pilot tool to be used for balanced reporting of benefits and harms. J Clin Epidemiol. 2018;93:9–24.PubMedCrossRef
45.
46.
Smith V, Devane D, Begley CM, Clarke M. Methodology in conducting a systematic review of systematic reviews of healthcare interventions. BMC Med Res Methodol. 2011;11(1):15.PubMedPubMedCentralCrossRef
47.
48.
Pollock M, Fernandes RM, Newton AS, Scott SD, Hartling L. A decision tool to help researchers make decisions about including systematic reviews in overviews of reviews of healthcare interventions. Syst Rev. 2019;8(1):29.PubMedPubMedCentralCrossRef
49.
Pollock M, Fernandes RM, Newton AS, Scott SD, Hartling L. The impact of different inclusion decisions on the comprehensiveness and complexity of overviews of reviews of healthcare interventions. Syst Rev. 2019;8(1):18.PubMedPubMedCentralCrossRef
50.
Sidik K, Jonkman JN. A simple confidence interval for meta-analysis. Stat Med. 2002;21(21):3153–9.PubMedCrossRef
51.
Higgins JP, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, et al. Cochrane handbook for systematic reviews of interventions: John Wiley & Sons; 2019.CrossRef
52.
Higgins J, Green S, Collaboration C. Cochrane handbook for systematic reviews of interventions: Wiley-Blackwell; 2008.CrossRef
53.
Balduzzi S, Rücker G, Schwarzer G. How to perform a meta-analysis with R: a practical tutorial. Evid Based Ment Health. 2019;22(4):153–60.PubMedCrossRef
54.
55.
Riley RD, Higgins JP, Deeks JJ. Interpretation of random effects meta-analyses. Bmj. 2011;342:d549.PubMedCrossRef
56.
Peters JL, Sutton AJ, Jones DR, Abrams KR, Rushton L. Contour-enhanced meta-analysis funnel plots help distinguish publication bias from other causes of asymmetry. J Clin Epidemiol. 2008;61(10):991–6.PubMedCrossRef
57.
58.
Duval S, Tweedie R. Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics. 2000;56(2):455–63.PubMedCrossRef
59.
Viechtbauer W. Conducting meta-analyses in R with the metafor package. Journal of Statistical Software. 2010;36(3):1–48.CrossRef
60.
Ioannidis JP. Excess significance bias in the literature on brain volume abnormalities. Arch Gen Psychiatry. 2011;68(8):773–80.PubMedCrossRef
61.
Ioannidis JP, Trikalinos TA. An exploratory test for an excess of significant findings. Clin Trials. 2007;4(3):245–53.PubMedCrossRef
62.
Ioannidis JPA. Clarifications on the application and interpretation of the test for excess significance and its extensions. J Math Psychol. 2013;57(5):184–7.CrossRef
63.
64.
Alizadeh S, Shab-Bidar S, Mohtavinejad N, Djafarian K. A posteriori dietary patterns and risk of pancreatic and renal cancers: a systematic review and meta-analysis. Nutr Food Sci. 2017;47(6):839–68.CrossRef
65.
Bai HW, Qian YY, Shi BY, Li G, Fan Y, Wang Z, et al. The association between fish consumption and risk of renal cancer: a meta-analysis of observational studies. PLoS One. 2013;8(11):e81939.PubMedPubMedCentralCrossRef
66.
Boyle P, Koechlin A, Autier P. Sweetened carbonated beverage consumption and cancer risk: meta-analysis and review. Eur J Cancer Prev. 2014;23(5):481–90.PubMedCrossRef
67.
68.
Clasen JL, Heath AK, Scelo G, Muller DC. Components of one-carbon metabolism and renal cell carcinoma: a systematic review and meta-analysis. Eur J Nutr. 2020;59(8):3801–13.PubMedPubMedCentralCrossRef
69.
Hu ZH, Lin YW, Xu X, Chen H, Mao YQ, Wu J, et al. No association between tea consumption and risk of renal cell carcinoma: a meta-analysis of epidemiological studies. Asian Pac J Cancer Prev. 2013;14(3):1691–5.PubMedCrossRef
70.
Huang TB, Ding PP, Chen JF, Yan Y, Zhang L, Liu H, et al. Dietary fiber intake and risk of renal cell carcinoma: evidence from a meta-analysis. Med Oncol. 2014;31(8):125.PubMedCrossRef
71.
Jayedi A, Emadi A, Shab-Bidar S. Dietary inflammatory index and site-specific cancer risk: a systematic review and dose-response meta-analysis. Adv Nutr. 2018;9(4):388–403.PubMedPubMedCentralCrossRef
72.
73.
Llaha F, Gil-Lespinard M, Unal P, de Villasante I, Castañeda J, Zamora-Ros R. Consumption of sweet beverages and cancer risk. A systematic review and meta-analysis of observational studies. Nutrients. 2021;13(2).
74.
Shen C, Huang Y, Yi S, Fang Z, Li L. Association of vitamin E intake with reduced risk of kidney cancer: a meta-analysis of observational studies. Med Sci Monit. 2015;21:3420–6.PubMedPubMedCentralCrossRef
75.
Wijarnpreecha K, Thongprayoon C, Thamcharoen N, Panjawatanan P, Cheungpasitporn W. Association between coffee consumption and risk of renal cell carcinoma: a meta-analysis. Intern Med J. 2017;47(12):1422–32.PubMedCrossRef
76.
Wu J, Yang N, Yuan M. Dietary and circulating vitamin D and risk of renal cell carcinoma: a meta-analysis of observational studies. Int Braz J Urol. 2021;47(4):733–44.PubMedCrossRef
77.
Xie L, Mo M, Jia HX, Liang F, Yuan J, Zhu J. Association between dietary nitrate and nitrite intake and sitespecific cancer risk: evidence from observational studies. Oncotarget. 2016;7(35):56915–32.PubMedPubMedCentralCrossRef
78.
Xu X, Zhu Y, Li J, Wang S. Dietary fiber, glycemic index, glycemic load and renal cell carcinoma risk. Carcinogenesis. 2019;40(3):441–7.PubMedCrossRef
79.
Xu X, Zhu Y, Zheng X, Xie L. Does beer, wine or liquor consumption correlate with the risk of renal cell carcinoma? A dose-response meta-analysis of prospective cohort studies. Oncotarget. 2015;6(15):13347–58.PubMedPubMedCentralCrossRef
80.
Zhang S, Jia Z, Yan Z, Yang J. Consumption of fruits and vegetables and risk of renal cell carcinoma: a meta-analysis of observational studies. Oncotarget. 2017;8(17):27892–903.PubMedPubMedCentralCrossRef
81.
Zhao J, Zhao L. Cruciferous vegetables intake is associated with lower risk of renal cell carcinoma: evidence from a meta-analysis of observational studies. PLoS One. 2013;8(10):e75732.PubMedPubMedCentralCrossRef
82.
Bellocco R, Pasquali E, Rota M, Bagnardi V, Tramacere I, Scotti L, et al. Alcohol drinking and risk of renal cell carcinoma: results of a meta-analysis. Ann Oncol. 2012;23(9):2235–44.PubMedCrossRef
83.
Huang TB, Guo ZF, Zhang XL, Zhang XP, Liu H, Geng J, et al. Coffee consumption and urologic cancer risk: a meta-analysis of cohort studies. Int Urol Nephrol. 2014;46(8):1481–93.PubMedCrossRef
84.
Liu B, Mao Q, Wang X, Zhou F, Luo J, Wang C, et al. Cruciferous vegetables consumption and risk of renal cell carcinoma: a meta-analysis. Nutr Cancer. 2013;65(5):668–76.PubMedCrossRef
85.
Shang Y, Yi S, Cui D, Han G, Liu C. Vitamin E intake and risk of renal cell carcinoma: a meta-analysis of 7 case-control studies. J Ren Nutr. 2015;25(4):339–44.PubMedCrossRef
86.
87.
88.
World Cancer Research Fund/American Institute for Cancer Research. Continuous Update Project Expert Report 2018. Diet, nutrition, physical activity and kidney cancer. 2018 [Available from: dietandcancerrep​ort.​org].
89.
Adams VR, Leggas M. Sunitinib malate for the treatment of metastatic renal cell carcinoma and gastrointestinal stromal tumors. Clin Ther. 2007;29(7):1338–53.PubMedCrossRef
90.
91.
Bara T Jr, Gurzu S, Sugimura H, Bara T, Beleaua MA, Jung I. A systematic review of the possible carcinogenic role of the aristolochic acid. Rom J Morphol Embryol. 2017;58(1):41–4.PubMed
92.
Biggar PH, Liangos O, Fey H, Brandenburg VM, Ketteler M. Vitamin D, chronic kidney disease and survival: a pluripotent hormone or just another bone drug? Pediatr Nephrol. 2011;26(1):7–18.PubMedCrossRef
93.
Caprio GG, Picascia D, Dallio M, Vitiello PP, Giunta EF, De Falco V, et al. Light alcohol drinking and the risk of cancer development: a controversial relationship. Rev Recent Clin Trials. 2020;15(3):164–77.PubMedCrossRef
94.
95.
Fang J, Xu X, Mao Q, Ying Y, Zhang X, Xie L. Lower circulating adiponectin is associated with higher risk of renal cell carcinoma: a meta-analysis. Int J Biol Markers. 2020;35(1):57–64.PubMedCrossRef
96.
Fox CH, Eberl M. Phytic acid (IP6), novel broad spectrum anti-neoplastic agent: a systematic review. Complement Ther Med. 2002;10(4):229–34.PubMedCrossRef
97.
Gandini S, Gnagnarella P, Serrano D, Pasquali E, Raimondi S. Vitamin D receptor polymorphisms and cancer. Adv Exp Med Biol. 2014;810:69–105.PubMed
98.
Gnagnarella P, Raimondi S, Aristarco V, Johansson HA, Bellerba F, Corso F, et al. Vitamin D receptor polymorphisms and cancer. Adv Exp Med Biol. 2020;1268:53–114.PubMedCrossRef
99.
Gouveia MC, Vella JP, Cafeo FR, Affonso Fonseca FL, Bacci MR. Association between irisin and major chronic diseases: a review. Eur Rev Med Pharmacol Sci. 2016;20(19):4072–7.PubMed
100.
Graff RE, Cho E, Preston MA, Sanchez A, Mucci LA, Wilson KM. Dietary acrylamide intake and risk of renal cell carcinoma in two large prospective cohorts. Cancer Epidemiol Biomarkers Prev. 2018;27(8):979–82.PubMedPubMedCentralCrossRef
101.
Händel MN, Cardoso I, Rasmussen KM, Rohde JF, Jacobsen R, Nielsen SM, et al. Processed meat intake and chronic disease morbidity and mortality: an overview of systematic reviews and meta-analyses. PLoS One. 2019;14(10):e0223883.PubMedPubMedCentralCrossRef
102.
103.
Jeyaraman MM, Abou-Setta AM, Grant L, Farshidfar F, Copstein L, Lys J, et al. Dairy product consumption and development of cancer: an overview of reviews. BMJ Open. 2019;9(1):e023625.PubMedPubMedCentralCrossRef
104.
105.
106.
Key TJ, Schatzkin A, Willett WC, Allen NE, Spencer EA, Travis RC. Diet, nutrition and the prevention of cancer. Public Health Nutr. 2004;7(1a):187–200.PubMedCrossRef
107.
Khan MI, Bielecka ZF, Najm MZ, Bartnik E, Czarnecki JS, Czarnecka AM, et al. Vitamin D receptor gene polymorphisms in breast and renal cancer: current state and future approaches (review). Int J Oncol. 2014;44(2):349–63.PubMedCrossRef
108.
Krajewski W, Dzięgała M, Kołodziej A, Dembowski J, Zdrojowy R. Vitamin D and urological cancers. Cent European J Urol. 2016;69(2):139–47.PubMedPubMedCentral
109.
Kume H, Takahashi S, Teramoto S, Isurugi K. Risk factors for adult renal cell carcinoma: a systematic review and implications for prevention. BJU Int. 2001;88(7):804.PubMed
110.
Latino-Martel P, Cottet V, Druesne-Pecollo N, Pierre FH, Touillaud M, Touvier M, et al. Alcoholic beverages, obesity, physical activity and other nutritional factors, and cancer risk: a review of the evidence. Crit Rev Oncol Hematol. 2016;99:308–23.PubMedCrossRef
111.
Lenko V, Bialesova L, Macejova D, Bujdak P, Breza J, Brtko J. The relationship between renal cell carcinoma and nuclear retinoid/rexinoid receptors. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2013;157(4):316–24.PubMedCrossRef
112.
Ljungberg B, Campbell SC, Choi HY, Jacqmin D, Lee JE, Weikert S, et al. The epidemiology of renal cell carcinoma. Eur Urol. 2011;60(4):615–21.PubMedCrossRef
113.
Luong K, Nguyen LT. The beneficial role of vitamin D and its analogs in cancer treatment and prevention. Crit Rev Oncol Hematol. 2010;73(3):192–201.PubMedCrossRef
114.
Miller PE, Snyder DC. Phytochemicals and cancer risk: a review of the epidemiological evidence. Nutr Clin Pract. 2012;27(5):599–612.PubMedCrossRef
115.
Niu X, Zhu Z, Bao J. Prognostic significance of pretreatment controlling nutritional status score in urological cancers: a systematic review and meta-analysis. Cancer Cell Int. 2021;21(1):126.PubMedPubMedCentralCrossRef
116.
Ouzzane A, Rouprêt M, Leon P, Yates DR, Colin P. Epidemiology and risk factors of upper urinary tract tumors: literature review for the yearly scientific report of the French National Association of Urology. Prog Urol. 2014;24(15):966–76.PubMedCrossRef
117.
Riboldi BP, Vinhas ÁM, Moreira JD. Risks of dietary acrylamide exposure: a systematic review. Food Chem. 2014;157:310–22.PubMedCrossRef
118.
Rumrich IK, Viluksela M, Vähäkangas K, Gissler M, Surcel HM, Hänninen O. Maternal smoking and the risk of cancer in early life - a meta-analysis. PLoS One. 2016;11(11):e0165040.PubMedPubMedCentralCrossRef
119.
120.
Ströhle A, Waldmann A, Wolters M, Hahn A. Vegetarian nutrition: Preventive potential and possible risks. Part 1: Plant foods. Wien Klin Wochenschr. 2006;118(19-20):580–93.PubMedCrossRef
121.
Teissedre PL, Rasines-Perea Z, Ruf JC, Stockley C, Antoce AO, Romano R, et al. Effects of alcohol consumption in general, and wine in particular, on the risk of cancer development: a review. OENE One. 2020;54(4):813–32.CrossRef
122.
Virk-Baker MK, Nagy TR, Barnes S, Groopman J. Dietary acrylamide and human cancer: a systematic review of literature. Nutr Cancer. 2014;66(5):774–90.PubMedPubMedCentralCrossRef
123.
Weikert S, Ljungberg B. Contemporary epidemiology of renal cell carcinoma: perspectives of primary prevention. World J Urol. 2010;28(3):247–52.PubMedCrossRef
124.
125.
Al-Bayati O, Hasan A, Pruthi D, Kaushik D, Liss MA. Systematic review of modifiable risk factors for kidney cancer. Urol Oncol. 2019;37(6):359–71.PubMedCrossRef
126.
Darling AL, Abar L, Norat T. WCRF-AICR continuous update project: Systematic literature review of prospective studies on circulating 25-hydroxyvitamin D and kidney cancer risk. J Steroid Biochem Mol Biol. 2016;164:85–9.PubMedCrossRef
127.
Dhote R, Thiounn N, Debré B, Vidal-Trecan G. Risk factors for adult renal cell carcinoma. Urol Clin North Am. 2004;31(2):237–47.PubMedCrossRef
128.
Dhôte R, Pellicer-Coeuret M, Thiounn N, Debré B, Vidal-Trecan G. Risk factors for adult renal cell carcinoma: a systematic review and implications for prevention. BJU Int. 2000;86(1):20–7.PubMedCrossRef
129.
Javed F, Bello Correra FO, Chotai M, Tappuni AR, Almas K. Systemic conditions associated with areca nut usage: a literature review. Scand J Public Health. 2010;38(8):838–44.PubMedCrossRef
130.
Jiang F, Teng M, Zhu YX, Li YJ. No association between dietary acrylamide and renal cell carcinoma: an updated meta-analysis. J Sci Food Agric. 2020;100(7):3071–7.PubMedCrossRef
131.
Johnson C, Raj TS, Trudeau L, Bacon SL, Padwal R, Webster J, et al. The science of salt: a systematic review of clinical salt studies 2013 to 2014. J Clin Hypertens (Greenwich). 2015;17(5):401–11.PubMedCentralCrossRef
132.
Kim JY, Kwon O. Garlic intake and cancer risk: an analysis using the Food and Drug Administration’s evidence-based review system for the scientific evaluation of health claims. Am J Clin Nutr. 2009;89(1):257–64.PubMedCrossRef
133.
Lin G, Ning L, Gu D, Li S, Yu Z, Long Q, et al. Examining the association of circulating 25-hydroxyvitamin D with kidney cancer risk: a meta-analysis. Int J Clin Exp Med. 2015;8(11):20499–507.PubMedPubMedCentral
134.
Lipworth L, Tarone RE, McLaughlin JK. The epidemiology of renal cell carcinoma. J Urol. 2006;176(6 Pt 1):2353–8.PubMedCrossRef
135.
Mao B, Li Y, Zhang Z, Chen C, Chen Y, Ding C, et al. One-carbon metabolic factors and risk of renal cell cancer: a meta-analysis. PLoS One. 2015;10(10):e0141762.PubMedPubMedCentralCrossRef
136.
Pelucchi C, Bosetti C, Galeone C, La Vecchia C. Dietary acrylamide and cancer risk: an updated meta-analysis. Int J Cancer. 2015;136(12):2912–22.PubMedCrossRef
137.
Pelucchi C, La Vecchia C, Bosetti C, Boyle P, Boffetta P. Exposure to acrylamide and human cancer--a review and meta-analysis of epidemiologic studies. Ann Oncol. 2011;22(7):1487–99.PubMedCrossRef
138.
Rosato V, Negri E, Serraino D, Montella M, Libra M, Lagiou P, et al. Processed meat and risk of renal cell and bladder cancers. Nutr Cancer. 2018;70(3):418–24.PubMedCrossRef
139.
Yip CSC, Chan W, Fielding R. The associations of fruit and vegetable intakes with burden of diseases: a systematic review of meta-analyses. J Acad Nutr Diet. 2019;119(3):464–81.PubMedCrossRef
140.
141.
Navai N, Wood CG. Environmental and modifiable risk factors in renal cell carcinoma. Urol Oncol. 2012;30(2):220–4.PubMedCrossRef
142.
Washio M, Mori M. Risk factors for kidney cancer (renal cell carcinoma) in a Japanese population: a mini-review. International Medical Journal. 2011;18(3):220–3.
143.
Boeing H, Schlehofer B, Wahrendorf J. Diet, obesity and risk for renal cell carcinoma: results from a case control-study in Germany. Z Ernahrungswiss. 1997;36(1):3–11.PubMedCrossRef
144.
Gallicchio L, Moore LE, Stevens VL, Ahn J, Albanes D, Hartmuller V, et al. Circulating 25-hydroxyvitamin D and risk of kidney cancer: cohort consortium vitamin D pooling project of rarer cancers. Am J Epidemiol. 2010;172(1):47–57.PubMedPubMedCentralCrossRef
145.
146.
Ljungberg B, Albiges L, Bedke J, Bex A, Capitanio U, Giles RH, et al. EAU – ESTRO – ESUR – SIOG Guidelines on Renal Cell Carcinoma. Edn. presented at the EAU Annual Congress Milan 2021. Arnhem, The Netherlands: EAU Guidelines Office; 2021.
147.
Bradlee ML, Singer MR, Qureshi MM, Moore LL. Food group intake and central obesity among children and adolescents in the Third National Health and Nutrition Examination Survey (NHANES III). Public Health Nutr. 2010;13(6):797–805.PubMedCrossRef
148.
Silva D, Cunha KAD, Segheto W, Reis VG, Coelho FA, Morais SHO, et al. Behavioral patterns that increase or decrease risk of abdominal adiposity in adults. Nutr Hosp. 2018;35(1):90–7.PubMedCrossRef
149.
Koebnick C, Black MH, Wu J, Shu YH, MacKay AW, Watanabe RM, et al. A diet high in sugar-sweetened beverage and low in fruits and vegetables is associated with adiposity and a pro-inflammatory adipokine profile. Br J Nutr. 2018;120(11):1230–9.PubMedPubMedCentralCrossRef
150.
Dreher ML, Ford NA. A comprehensive critical assessment of increased fruit and vegetable intake on weight loss in women. Nutrients. 2020;12(7).
151.
Takagi T, Hayashi R, Nakai Y, Okada S, Miyashita R, Yamada M, et al. Dietary intake of carotenoid-rich vegetables reduces visceral adiposity in obese Japanese men-a randomized, double-blind trial. Nutrients. 2020;12(8).
152.
Zhang Y. Cancer-preventive isothiocyanates: measurement of human exposure and mechanism of action. Mutat Res. 2004;555(1-2):173–90.PubMedCrossRef
153.
Liu RH. Potential synergy of phytochemicals in cancer prevention: mechanism of action. J Nutr. 2004;134(12 Suppl):3479s-85s.
154.
Tang L, Zhang Y. Isothiocyanates in the chemoprevention of bladder cancer. Curr Drug Metab. 2004;5(2):193–201.PubMedCrossRef
155.
Zhang Y, Talalay P, Cho CG, Posner GH. A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure. Proc Natl Acad Sci U S A. 1992;89(6):2399–403.PubMedPubMedCentralCrossRef
156.
Conaway CC, Getahun SM, Liebes LL, Pusateri DJ, Topham DK, Botero-Omary M, et al. Disposition of glucosinolates and sulforaphane in humans after ingestion of steamed and fresh broccoli. Nutr Cancer. 2000;38(2):168–78.PubMedCrossRef
157.
Mahéo K, Morel F, Langouët S, Kramer H, Le Ferrec E, Ketterer B, et al. Inhibition of cytochromes P-450 and induction of glutathione S-transferases by sulforaphane in primary human and rat hepatocytes. Cancer Res. 1997;57(17):3649–52.PubMed
158.
Tang L, Zhang Y, Jobson HE, Li J, Stephenson KK, Wade KL, et al. Potent activation of mitochondria-mediated apoptosis and arrest in S and M phases of cancer cells by a broccoli sprout extract. Mol Cancer Ther. 2006;5(4):935–44.PubMedCrossRef
159.
Tang L, Zhang Y. Mitochondria are the primary target in isothiocyanate-induced apoptosis in human bladder cancer cells. Mol Cancer Ther. 2005;4(8):1250–9.PubMedCrossRef
160.
Tang L, Zhang Y. Dietary isothiocyanates inhibit the growth of human bladder carcinoma cells. J Nutr. 2004;134(8):2004–10.PubMedCrossRef
161.
Tang L, Li G, Song L, Zhang Y. The principal urinary metabolites of dietary isothiocyanates, N-acetylcysteine conjugates, elicit the same anti-proliferative response as their parent compounds in human bladder cancer cells. Anticancer Drugs. 2006;17(3):297–305.PubMedCrossRef
162.
Chinni SR, Li Y, Upadhyay S, Koppolu PK, Sarkar FH. Indole-3-carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest and apoptosis in prostate cancer cells. Oncogene. 2001;20(23):2927–36.PubMedCrossRef
163.
Cover CM, Hsieh SJ, Tran SH, Hallden G, Kim GS, Bjeldanes LF, et al. Indole-3-carbinol inhibits the expression of cyclin-dependent kinase-6 and induces a G1 cell cycle arrest of human breast cancer cells independent of estrogen receptor signaling. J Biol Chem. 1998;273(7):3838–47.PubMedCrossRef
164.
Mendoza-Pérez J, Gu J, Herrera LA, Tannir NM, Zhang S, Matin S, et al. Prognostic significance of promoter CpG island methylation of obesity-related genes in patients with nonmetastatic renal cell carcinoma. Cancer. 2017;123(18):3617–27.PubMedCrossRef
165.
Shenoy N, Bhagat TD, Cheville J, Lohse C, Bhattacharyya S, Tischer A, et al. Ascorbic acid-induced TET activation mitigates adverse hydroxymethylcytosine loss in renal cell carcinoma. J Clin Invest. 2019;129(4):1612–25.PubMedPubMedCentralCrossRef
166.
Shim EH, Livi CB, Rakheja D, Tan J, Benson D, Parekh V, et al. L-2-Hydroxyglutarate: an epigenetic modifier and putative oncometabolite in renal cancer. Cancer Discov. 2014;4(11):1290–8.PubMedPubMedCentralCrossRef
167.
168.
Haffner MC, Chaux A, Meeker AK, Esopi DM, Gerber J, Pellakuru LG, et al. Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers. Oncotarget. 2011;2(8):627–37.PubMedPubMedCentralCrossRef
169.
Jin SG, Jiang Y, Qiu R, Rauch TA, Wang Y, Schackert G, et al. 5-Hydroxymethylcytosine is strongly depleted in human cancers but its levels do not correlate with IDH1 mutations. Cancer Res. 2011;71(24):7360–5.PubMedPubMedCentralCrossRef
170.
Kraus TF, Globisch D, Wagner M, Eigenbrod S, Widmann D, Münzel M, et al. Low values of 5-hydroxymethylcytosine (5hmC), the “sixth base,” are associated with anaplasia in human brain tumors. Int J Cancer. 2012;131(7):1577-1590.
171.
Kudo Y, Tateishi K, Yamamoto K, Yamamoto S, Asaoka Y, Ijichi H, et al. Loss of 5-hydroxymethylcytosine is accompanied with malignant cellular transformation. Cancer Sci. 2012;103(4):670–6.PubMedPubMedCentralCrossRef
172.
Okamoto K, Toyokuni S, Uchida K, Ogawa O, Takenewa J, Kakehi Y, et al. Formation of 8-hydroxy-2'-deoxyguanosine and 4-hydroxy-2-nonenal-modified proteins in human renal-cell carcinoma. Int J Cancer. 1994;58(6):825–9.PubMedCrossRef
173.
Umemura T, Sai K, Takagi A, Hasegawa R, Kurokawa Y. Formation of 8-hydroxydeoxyguanosine (8-OH-dG) in rat kidney DNA after intraperitoneal administration of ferric nitrilotriacetate (Fe-NTA). Carcinogenesis. 1990;11(2):345–7.PubMedCrossRef
174.
Daniel CR, Cross AJ, Graubard BI, Park Y, Ward MH, Rothman N, et al. Large prospective investigation of meat intake, related mutagens, and risk of renal cell carcinoma. Am J Clin Nutr. 2012;95(1):155–62.PubMedCrossRef
175.
Karami S, Daugherty SE, Purdue MP. A prospective study of alcohol consumption and renal cell carcinoma risk. Int J Cancer. 2015;137(1):238–42.PubMedCrossRef
176.
Lew JQ, Chow WH, Hollenbeck AR, Schatzkin A, Park Y. Alcohol consumption and risk of renal cell cancer: the NIH-AARP diet and health study. Br J Cancer. 2011;104(3):537–41.PubMedPubMedCentralCrossRef
177.
Macleod LC, Hotaling JM, Wright JL, Davenport MT, Gore JL, Harper J, et al. Risk factors for renal cell carcinoma in the VITAL study. J Urol. 2013;190(5):1657–61.PubMedPubMedCentralCrossRef
178.
Papadimitriou N, Markozannes G, Kanellopoulou A, Critselis E, Alhardan S, Karafousia V, et al. An umbrella review of the evidence associating diet and cancer risk at 11 anatomical sites. Nat Commun. 2021;12(1):4579.PubMedPubMedCentralCrossRef
179.
Sterne JA, Sutton AJ, Ioannidis JP, Terrin N, Jones DR, Lau J, et al. Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials. Bmj. 2011;343:d4002.PubMedCrossRef
180.
Teissedre P-L, Rasines-Perea Z, Ruf J-C, Stockley C, Antoce AO, Romano R, et al. Effects of alcohol consumption in general, and wine in particular, on the risk of cancer development: a review. OENE One. 2020;54(4):813–32.CrossRef
181.
Grandi SM, Filion KB, Yoon S, Ayele HT, Doyle CM, Hutcheon JA, et al. Cardiovascular disease-related morbidity and mortality in women with a history of pregnancy complications. Circulation. 2019;139(8):1069–79.PubMedCrossRef
Metadata
Title
The role of diet in renal cell carcinoma incidence: an umbrella review of meta-analyses of observational studies
Authors
Zhanchen Liao
Zhitao Fang
Siqi Gou
Yong Luo
Yiqi Liu
Zhun He
Xin Li
Yansong Peng
Zheng Fu
Dongjin Li
Haiyun Chen
Zhigang Luo
Publication date
01-12-2022
Publisher
BioMed Central
Published in
BMC Medicine / Issue 1/2022
Electronic ISSN: 1741-7015
DOI
https://doi.org/10.1186/s12916-021-02229-5

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