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01-12-2021 | Atrial Fibrillation | MedViews

Mendelian randomization—a powerful tool to study the causal effects of atrial fibrillation on loss of brain volume

Author: Laura Andreasen

Published in: BMC Medicine | Issue 1/2021

Excerpt

Atrial fibrillation (AF) affects a growing proportion of the population, especially the elderly, and has previously been proven to increase the risk of cognitive impairment and dementia independently of stroke [1]. Previous studies have associated AF with loss of brain volume and the association appears to increase with age [2, 3]. The underlying pathophysiological mechanisms between AF, brain volume loss, and cognitive impairment, however, remain unknown. Park et al. [4] sought to investigate the causal effect of AF on brain volume loss using data from genome-wide association studies (GWAS) in a Mendelian randomization (MR) analysis setup. …

Hindricks G, Potpara T, Dagres N, Arbelo E, Bax JJ, Blomström-Lundqvist C, et al. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS): The Task Force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC. Eur Heart J. 2021;42:373–498.CrossRef

Moazzami K, Shao IY, Chen LY, Lutsey PL, Jack CR, Mosley T, et al. Atrial fibrillation, brain volumes, and subclinical cerebrovascular disease (from the Atherosclerosis Risk in Communities Neurocognitive Study [ARIC-NCS]). Am J Cardiol. 2020;125:222–8.CrossRef

Stefansdottir H, Arnar DO, Aspelund T, Sigurdsson S, Jonsdottir MK, Hjaltason H, et al. Atrial fibrillation is associated with reduced brain volume and cognitive function independent of cerebral infarcts. Stroke. 2013;44:1020–5.CrossRef

Park S, Lee S, Kim Y, Cho S, Kim K, Kim YC, et al. Causal effect of atrial fibrillation on brain white or grey matter volume: a Mendelian randomization study. medRxiv. 2020; 2020.12.17.20248314.

Davey Smith G, Ebrahim S. ‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease?*. Int J Epidemiol. 2003;32:1–22.CrossRef

Title: Mendelian randomization—a powerful tool to study the causal effects of atrial fibrillation on loss of brain volume
Author: Laura Andreasen
Publication date: 01-12-2021
Publisher: BioMed Central
Keyword: Atrial Fibrillation
Published in: BMC Medicine / Issue 1/2021
Electronic ISSN: 1741-7015
DOI: https://doi.org/10.1186/s12916-021-01946-1

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