Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
ADVANCED SEARCH
Log in
Top
BMC Medicine
Published in: BMC Medicine 1/2017

Open Access 01-12-2017 | Commentary

Highlights in soft tissue sarcomas and gastrointestinal stromal tumours (GIST) trials reported at ASCO 2017 Annual Meeting

Authors: Anna Maria Frezza, Silvia Stacchiotti, Alessandro Gronchi

Published in: BMC Medicine | Issue 1/2017

Login to get access

Abstract

Herein, we summarise the results of the most relevant studies presented at the 2017 ASCO Annual Meeting in the field of soft tissue sarcomas (STSs) and gastrointestinal stromal tumours (GISTs). Innovations on the management of localised disease, highlights from the different experiences in the metastatic setting and large studies on rare histologies will be included. Special attention will be paid to results on immunotherapy, antiangiogenics use in histology with limited sensitivity to standard chemotherapy and new compounds. The preliminary results on the impact of the next generation sequencing in the everyday management of STS and GIST patients will be also discussed.
Literature
1.
Pasquali S, Colombo C, Bottelli S, et al. The sarculator stratified prognosis of patients with high-risk soft tissue sarcomas (STS) of extremities and trunk wall treated with perioperative chemotherapy in a randomised controlled trial (RCT). 2017 ASCO Annual Meeting. J Clin Oncol. 2017;35:(suppl; abstr 11016).
2.
Gronchi A, Hindi N, Cruz J, et al. Trabectedin and radiotherapy in soft-tissue sarcoma (TRASTS) study: An international, prospective, phase I/II trial—A collaborative Spanish (GEIS), Italian (ISG), and French (FSG) groups study. 2017 ASCO Annual Meeting. J Clin Oncol. 2017;35:(suppl; abstr 11061).
3.
Raut CP, Espat J, Maki RG, et al. PERSIST-5: five year extended treatment with adjuvant imatinib for patients with intermediate/high risk primary gastrointestinal stromal tumor (GIST). 2017 ASCO Annual Meeting. J Clin Oncol. 2017;35:(suppl; abstr 11009).
4.
Chawla SP, Ganjoo KN, Schuetze S, et al. Phase III study of aldoxorubicin vs investigators' choice as treatment for relapsed/refractory soft tissue sarcomas. 2017 ASCO Annual Meeting. J Clin Oncol 2017;35:(suppl; abstr 11000).
5.
Eilber FC, Sankhala KK, Chawla SP, et al. Administration of aldoxorubicin and 14 days continuous infusion of ifosfamide/mesna in metastatic or locally advanced sarcomas. 2017 ASCO Annual Meeting. J Clin Oncol. 2017;35:(suppl; abstr 11051).
6.
Judson IR, Morden JP, Leahy MG, et al. Activity of cediranib in alveolar soft part sarcoma (ASPS) confirmed by CASPS (cediranib in ASPS), an international, randomised phase II trial (C2130/A12118). 2017 ASCO Annual Meeting. J Clin Oncol. 2017;35:(suppl; abstr 11004).
7.
Broto JM, Stacchiotti S, Lopez-Pousa A, et al. Multi-institutional European single-arm phase II trial of pazopanib in advanced malignant/dedifferentiated solitary fibrous tumors (SFT): A collaborative Spanish (GEIS), Italian (ISG), and French (FSG) sarcoma groups study. 2017 ASCO Annual Meeting. J Clin Oncol. 2017;35:(suppl; abstr 11003).
8.
Stacchiotti S, Ferrari S, Redondo A, et al. International single-arm phase II trial of pazopanib in advanced extraskeletal myxoid chondrosarcoma: A Collaborative Spanish (GEIS), Italian (ISG) and French (FSG) Sarcoma Groups study. 2017 ASCO Annual Meeting. J Clin Oncol. 2017;35:(suppl; abstr 11062).
9.
Attia S, Bolejack V, Ganjoo KN, et al. A phase II trial of regorafenib (REGO) in patients (pts) with advanced Ewing sarcoma and related tumors (EWS) of soft tissue and bone: SARC024 trial results. 2017 ASCO Annual Meeting. J Clin Oncol. 2017;35:(suppl; abstr 11005).
10.
Frezza AM, Asano N, Jones R, et al. Anthracycline, gemcitabine, and pazopanib in epithelioid sarcoma: Results of a retrospective multi-institutional case series. 2017 ASCO Annual Meeting. J Clin Oncol. 2017;35:(suppl; abstr 11065).
11.
Gounder NM, Stacchiotti S, Schöffski P, et al. Phase 2 multicenter study of the EZH2 inhibitor tazemetostat in adults with INI1 negative epithelioid sarcoma (NCT02601950). 2017 ASCO Annual Meeting. J Clin Oncol. 2017;35:(suppl; abstr 11058).
12.
Heinrich MC, Jones RL, von Mehren M, et al. GIST: imatinib and beyond - clinical activity of BLU-285 in advanced gastrointestinal stromal tumor (GIST). 2017 ASCO Annual Meeting. J Clin Oncol. 2017;35:(suppl; abstr 11011).
13.
D’Angelo SP, Mahoney MR, Van Tine BA, et al. A multi-center phase II study of nivolumab +/- ipilimumab for patients with metastatic sarcoma (Alliance A091401). 2017 ASCO Annual Meeting. J Clin Oncol. 2017;35:(suppl; abstr 11007).
14.
Burgess MA, Bolejack V, Van Tine BA, et al. Multicenter phase II study of pembrolizumab (P) in advanced soft tissue (STS) and bone sarcomas (BS): Final results of SARC028 and biomarker analyses. 2017 ASCO Annual Meeting. J Clin Oncol. 2017;35:(suppl; abstr 11008).
15.
Toulmonde M, Penel N, Adam J, et al. Combination of pembrolizumab and metronomic cyclophosphamide in patients with advanced sarcomas and GIST: A French Sarcoma Group phase II trial. 2017 ASCO Annual Meeting. J Clin Oncol. 2017;35:(suppl; abstr 11053).
16.
Komarov Y, Barchuk A, Semenova AI, et al. NY-ESO-1 antigen expression as a prognostic factor for soft tissue sarcomas. 2017 ASCO Annual Meeting. J Clin Oncol. 2017;35:(suppl; abstr 11075).
17.
Endo M, de Graff MA, Ingram DR, et al. NY-ESO-1 (CTAG1B) expression in mesenchymal tumors. Modern Pathol. 2015;28(4):587–95.CrossRef
18.
Somaiah N, Chawla SP, Block MS, et al. Immune response, safety, and survival impact from CMB305 in NY-ESO-1+ recurrent soft tissue sarcomas (STS). 2017 ASCO Annual Meeting. J Clin Oncol. 2017;35:(suppl; abstr 11006).
19.
Gounder M, Ali MS, Robinson V, et al. Impact of next-generation sequencing (NGS) on diagnostic and therapeutic options in soft-tissue and bone sarcoma. 2017 ASCO Annual Meeting. J Clin Oncol. 2017;35:(suppl; abstr 11001).
20.
Italiano A, Khalifa E, Laizet Y, Toulmonde M, Cousin S, Lucchesi C. Genetic landscape of soft-tissue sarcomas: moving toward personalized medicine. 2017 ASCO Annual Meeting. J Clin Oncol. 2017;35:(suppl; abstr 11002).
21.
Kelly CM, Bowler TG, D’Angelo SP, et al. The clinical impact of performing routine next generation sequencing in gastrointestinal stromal tumors (GIST). 2017 ASCO Annual Meeting. J Clin Oncol. 2017;35:(suppl; abstr 11010).
22.
Metadata
Title
Highlights in soft tissue sarcomas and gastrointestinal stromal tumours (GIST) trials reported at ASCO 2017 Annual Meeting
Authors
Anna Maria Frezza
Silvia Stacchiotti
Alessandro Gronchi
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Medicine / Issue 1/2017
Electronic ISSN: 1741-7015
DOI
https://doi.org/10.1186/s12916-017-0931-4

Other articles of this Issue 1/2017

BMC Medicine 1/2017 Go to the issue

Research article

Metabonomics uncovers a reversible proatherogenic lipid profile during infliximab therapy of inflammatory bowel disease

Research article

Use of malaria rapid diagnostic tests by community health workers in Afghanistan: cluster randomised trial

Research article

Effects of unconditional cash transfers on the outcome of treatment for severe acute malnutrition (SAM): a cluster-randomised trial in the Democratic Republic of the Congo

Research article

Association of bariatric surgery with risk of acute care use for hypertension-related disease in obese adults: population-based self-controlled case series study

Research article

What works for whom in the management of diabetes in people living with dementia: a realist review

Research article

Modest heterologous protection after Plasmodium falciparum sporozoite immunization: a double-blind randomized controlled clinical trial