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At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
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BMC Medicine
Published in: BMC Medicine 1/2017

Open Access 01-12-2017 | Opinion

Gestational diabetes mellitus—right person, right treatment, right time?

Authors: Robert S. Lindsay, Sharon T. Mackin, Scott M. Nelson

Published in: BMC Medicine | Issue 1/2017

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Abstract

Background

Personalised treatment that is uniquely tailored to an individual’s phenotype has become a key goal of clinical and pharmaceutical development across many, particularly chronic, diseases. For type 2 diabetes, the importance of the underlying clinical heterogeneity of the condition is emphasised and a range of treatments are now available, with personalised approaches being developed. While a close connection between risk factors for type 2 diabetes and gestational diabetes has long been acknowledged, stratification of screening, treatment and obstetric intervention remains in its infancy.

Conclusions

Although there have been major advances in our understanding of glucose tolerance in pregnancy and of the benefits of treatment of gestational diabetes, we argue that far more vigorous approaches are needed to enable development of companion diagnostics, and to ensure the efficacious and safe use of novel therapeutic agents and strategies to improve outcomes in this common condition.
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Metadata
Title
Gestational diabetes mellitus—right person, right treatment, right time?
Authors
Robert S. Lindsay
Sharon T. Mackin
Scott M. Nelson
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Medicine / Issue 1/2017
Electronic ISSN: 1741-7015
DOI
https://doi.org/10.1186/s12916-017-0925-2

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