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BMC Medicine
Published in: BMC Medicine 1/2017

Open Access 01-12-2017 | Editorial

Spotlight on landmark oncology trials: the latest evidence and novel trial designs

Authors: Helena Earl, Stefano Molica, Piotr Rutkowski

Published in: BMC Medicine | Issue 1/2017

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Abstract

The era of precision oncology is marked with prominent successes in the therapy of advanced soft tissue sarcomas, breast cancer, ovarian cancer and haematological neoplasms, among others. Moreover, recent trials of immune checkpoint inhibitors in melanoma, non-small cell lung carcinoma, and head and neck cancers have significantly influenced the therapeutic landscape by providing promising evidence for immunotherapy efficacy in the adjuvant setting in high-risk locoregional disease. To speed up the introduction of targeted therapy for cancer patients, novel phase II trials are being designed, and may likely form the basis for the ‘landmark trials’ of the future. A special article collection in BMC Medicine, “Spotlight on landmark oncology trials”, features articles from invited experts on recent clinical practice-changing trials.
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Metadata
Title
Spotlight on landmark oncology trials: the latest evidence and novel trial designs
Authors
Helena Earl
Stefano Molica
Piotr Rutkowski
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Medicine / Issue 1/2017
Electronic ISSN: 1741-7015
DOI
https://doi.org/10.1186/s12916-017-0884-7

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