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BMC Medicine
Published in: BMC Medicine 1/2017

Open Access 01-12-2017 | Commentary

The 2016 classification criteria for primary Sjogren’s syndrome: what’s new?

Authors: Franco Franceschini, Ilaria Cavazzana, Laura Andreoli, Angela Tincani

Published in: BMC Medicine | Issue 1/2017

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Abstract

New 2016 ACR/EULAR classification criteria for primary Sjogren’s syndrome (SS) have been developed and endorsed by the ACR. The newly proposed criteria include simple-to-perform items.
Two important points of the new criteria should be considered. Firstly, they indicate that either salivary gland biopsy or anti-Ro must be positive in order to corroborate the inflammatory and autoimmune nature of the disease. Secondly, the criteria recognize the systemic nature of SS, namely that patients without salivary or ocular glandular symptoms, but with extraglandular manifestations and B cell activation markers were also included in the SS classification. Additionally, the new criteria modified some technical points. The ocular staining score threshold was increased to 5 due to the higher specificity. The immunological profile includes only anti-Ro antibodies, while positivity for antinuclear antibodies and rheumatoid factor or isolated anti-La was excluded due to a lack of specificity.
The 2016 ACR/EULAR criteria are suitable for early identification of SS, providing patients with the opportunity of enrollment in clinical trials for new specific treatment. Although validation has been successful, the real life application of these criteria will test their performance.
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Metadata
Title
The 2016 classification criteria for primary Sjogren’s syndrome: what’s new?
Authors
Franco Franceschini
Ilaria Cavazzana
Laura Andreoli
Angela Tincani
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Medicine / Issue 1/2017
Electronic ISSN: 1741-7015
DOI
https://doi.org/10.1186/s12916-017-0837-1

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