Top

Published in:

Open Access 01-12-2015 | Research article

Comparative safety of serotonin (5-HT₃) receptor antagonists in patients undergoing surgery: a systematic review and network meta-analysis

Authors: Andrea C Tricco, Charlene Soobiah, Erik Blondal, Areti A Veroniki, Paul A Khan, Afshin Vafaei, John Ivory, Lisa Strifler, Huda Ashoor, Heather MacDonald, Emily Reynen, Reid Robson, Joanne Ho, Carmen Ng, Jesmin Antony, Kelly Mrklas, Brian Hutton, Brenda R Hemmelgarn, David Moher, Sharon E Straus

Published in: BMC Medicine | Issue 1/2015

Abstract

Background

Serotonin (5-HT₃) receptor antagonists are commonly used to decrease nausea and vomiting for surgery patients, but these agents may be harmful. We conducted a systematic review on the comparative safety of 5-HT₃ receptor antagonists.

Methods

Searches were done in MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials to identify studies comparing 5-HT₃ receptor antagonists with each other, placebo, and/or other antiemetic agents for patients undergoing surgical procedures. Screening search results, data abstraction, and risk of bias assessment were conducted by two reviewers independently. Random-effects pairwise meta-analysis and network meta-analysis (NMA) were conducted. PROSPERO registry number: CRD42013003564.

Results

Overall, 120 studies and 27,787 patients were included after screening of 7,608 citations and 1,014 full-text articles. Significantly more patients receiving granisetron plus dexamethasone experienced an arrhythmia relative to placebo (odds ratio (OR) 2.96, 95 % confidence interval (CI) 1.11–7.94), ondansetron (OR 3.23, 95 % CI 1.17–8.95), dolasetron (OR 4.37, 95 % CI 1.51–12.62), tropisetron (OR 3.27, 95 % CI 1.02–10.43), and ondansetron plus dexamethasone (OR 5.75, 95 % CI 1.71–19.34) in a NMA including 31 randomized clinical trials (RCTs) and 6,623 patients of all ages. No statistically significant differences in delirium frequency were observed across all treatment comparisons in a NMA including 18 RCTs and 3,652 patients.

Conclusion

Granisetron plus dexamethasone increases the risk of arrhythmia.

Available only for authorised users

Gan TJ, Meyer T, Apfel CC, Chung F, Davis PJ, Eubanks S, et al. Consensus guidelines for managing postoperative nausea and vomiting. Anesth Analg. 2003;97:62–71.PubMed

McCracken G, Houston P, Lefebvre G. Guideline for the management of postoperative nausea and vomiting. J Obstet Gynaecol Can. 2008;30:600–7.PubMed

Constenla M. 5-HT3 receptor antagonists for prevention of late acute-onset emesis. Ann Pharmacother. 2004;38:1683–91.PubMed

Buyukavci M, Olgun H, Ceviz N. The effects of ondansetron and granisetron on electrocardiography in children receiving chemotherapy for acute leukemia. Am J Clin Oncol. 2005;28:201–4.PubMed

Pinarli FG, Elli M, Dagdemir A, Baysal K, Acar S. Electrocardiographic findings after 5-HT3 receptor antagonists and chemotherapy in children with cancer. Pediatr Blood Cancer. 2006;47:567–71.PubMed

Gagnon ML. Moving knowledge to action through dissemination and exchange. J Clin Epidemiol. 2011;64:25–31.PubMed

Tricco AC, Soobiah C, Antony J, Hemmelgarn B, Moher D, Hutton B, et al. Safety of serotonin (5-HT3) receptor antagonists in patients undergoing surgery and chemotherapy: protocol for a systematic review and network meta-analysis. Syst Rev. 2013;2:46.PubMedPubMedCentral

Tricco AC, Soobiah C, Blondal E, Veroniki AA, Khan PA, Vafaei A et al. Comparative efficacy of serotonin (5-HT3) receptor antagonists in patients undergoing surgery: a systematic review and network meta-analysis. BMC Med. 2015; Ahead of print.

Carlisle JB. The analysis of 168 randomised controlled trials to test data integrity. Anaesthesia. 2012;67:521–37.PubMed

10.

Gan TJ, Gu J, Singla N, Chung F, Pearman MH, Bergese SD, et al. Rolapitant for the prevention of postoperative nausea and vomiting: a prospective, double-blinded, placebo-controlled randomized trial. Anesth Analg. 2011;112:804–12.PubMed

11.

Wells GA, Shea B, O’Connell D, Peterson J, Welch V, Losos M, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Ottawa: University of Ottawa; 2014.

12.

Glacy J, Putnam K, Godfrey S, Falzon L, Mauger B, Samson D, et al. Treatments for seasonal allergic rhinitis [Internet]. Rockville: Agency for Healthcare Research and Quality; 2013. (Comparative Effectiveness Reviews, No. 120.) Appendix F, McMaster Quality Assessment Scale of Harms (McHarm). http://www.ncbi.nlm.nih.gov/books/NBK153703/. Accessed Jan 2015.

13.

Raudenbush SW. Analyzing effect sizes: Random-effects models. In: Cooper H, Hedges LV, Valentine JC, editors. The handbook of research synthesis and meta-analysis. 2nd ed. New York: The Russell Sage Foundation; 2009. p. 295–316.

14.

Higgins JP, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. 2002;21:1539–58.PubMed

15.

Viechtbauer W. Conducting meta-analyses in R with the metafor package. J Stat Softw. 2010;36:1–48.

16.

R Core Team. R: A language and environment for statistical computing. http://www.R-project.org/. Accessed: Jan 2015.

17.

Salanti G. Indirect and mixed-treatment comparison, network, or multiple-treatments meta-analysis: many names, many benefits, many concerns for the next generation evidence synthesis tool. Res Synth Meth. 2012;3:80–97.

18.

Chaimani A, Higgins JP, Mavridis D, Spyridonos P, Salanti G. Graphical tools for network meta-analysis in STATA. PLoS One. 2013;8:e76654.PubMedPubMedCentral

19.

White IR, Barrett JK, Jackson D, Higgins J. Consistency and inconsistency in network meta‐analysis: model estimation using multivariate meta‐regression. Res Synth Meth. 2012;3:111–25.

20.

Song F, Altman DG, Glenny AM, Deeks JJ. Validity of indirect comparison for estimating efficacy of competing interventions: empirical evidence from published meta-analyses. BMJ. 2003;326:472.PubMedPubMedCentral

21.

Veroniki AA, Vasiliadis HS, Higgins JP, Salanti G. Evaluation of inconsistency in networks of interventions. Int J Epidemiol. 2013;42:332–45.PubMed

22.

Salanti G, Ades AE, Ioannidis JPA. Graphical methods and numerical summaries for presenting results from multiple-treatment meta-analysis: an overview and tutorial. J Clin Epidemiol. 2011;64:163–71.PubMed

23.

Chen CC, Lin CS, Ko YP, Hung YC, Lao HC, Hsu YW. Premedication with mirtazapine reduces preoperative anxiety and postoperative nausea and vomiting. Anesth Analg. 2008;106:109–13.PubMed

24.

Omran HASA, Nasr DAM. Effect of premedication with mirtazapine versus ondansetron on postoperative nausea and vomiting in breast surgery. Egypt J Anaesth. 2011;27:135–9.

25.

Homesley HD, Hahne WF, McLees B, Heck K, Barrett RJ, Lentz SS, et al. Randomized comparison of the antiemetic efficacy of a serotonin type 3 receptor antagonist (MDL 72,222) with a high-dose metoclopramide regimen. Am J Clin Oncol. 1993;16:175–9.PubMed

26.

Gan TJ, Meyer TA, Apfel CC, Chung F, Davis PJ, Habib AS, et al. Society for Ambulatory Anesthesia guidelines for the management of postoperative nausea and vomiting. Anesth Analg. 2007;105:1615–28.PubMed

27.

Golembiewski J, Chernin E, Chopra T. Prevention and treatment of postoperative nausea and vomiting. Am J Health Syst Pharm. 2005;62:1247–60.PubMed

28.

Kovac AL. Prevention and treatment of postoperative nausea and vomiting. Drugs. 2000;59:213–43.PubMed

29.

Wilhelm SM, Dehoorne-Smith ML, Kale-Pradhan PB. Prevention of postoperative nausea and vomiting. Ann Pharmacother. 2007;41(1):68–78. Epub 2007 Jan 2.PubMed

30.

Yun MJ, Kim YH, Kim AR. Comparison of azasetron and ondansetron for preventing postoperative nausea and vomiting in patients undergoing gynecological laparoscopic surgery. Yonsei Med J. 2010;51:88–92.PubMed

31.

Gunter JB, McAuliffe JJ, Beckman EC, Wittkugel EP, Spaeth JP, Varughese AM. A factorial study of ondansetron, metoclopramide, and dexamethasone for emesis prophylaxis after adenotonsillectomy in children. Paediatr Anaesth. 2006;16:1153–65.PubMed

32.

Gupta P, Khanna J, Mitramustafi AK, Bhartia VK. Role of pre-operative dexamethasone as prophylaxis for postoperative nausea and vomiting in laparoscopic surgery. J Minim Access Surg. 2006;2:12–5.PubMedPubMedCentral

33.

Gupta SD, Pal R, Sarkar A, Mukherjee S, Mitra K, Roy S, et al. Evaluation of Ondansetron-induced QT interval prolongation in the prophylaxis of postoperative emesis. J Nat Sci Biol Med. 2011;2:119–24.PubMedPubMedCentral

34.

Riley RD, Higgins JPT, Deeks JJ. Interpretation of random effects meta-analyses. BMJ. 2011;342:964–7.

35.

Higgins JP, Thompson SG, Spiegelhalter DJ. A re-evaluation of random-effects meta-analysis. J R Stat Soc Ser A Stat Soc. 2009;172:137–59.PubMedPubMedCentral

36.

White IR. Multivariate random-effects meta-regression: updates to mvmeta. Stata J. 2011;11:255–70.

37.

StataCorp. Stata Statistical Software: Release 13. College Station: StataCorp LP; 2013.

38.

Choi YS, Shim JK, Ahn SH, Kwak YL. Efficacy comparison of ramosetron with ondansetron on preventing nausea and vomiting in high-risk patients following spine surgery with a single bolus of dexamethasone as an adjunct. Korean J Anesthesiol. 2012;62:543–7.PubMedPubMedCentral

39.

Wang PK, Tsay PJ, Huang CC, Lai HY, Lin PC, Huang SJ, et al. Comparison of dexamethasone with ondansetron or haloperidol for prevention of patient-controlled analgesia-related postoperative nausea and vomiting: a randomized clinical trial. World J Surg. 2012;36:775–81.PubMed

40.

Ekinci O, Malat I, Isitmangil G, Aydin N. A randomized comparison of droperidol, metoclopramide, tropisetron, and ondansetron for the prevention of postoperative nausea and vomiting. Gynecol Obstet Invest. 2011;71:59–65.PubMed

41.

Park SK, Cho EJ. A randomized, double-blind trial of palonosetron compared with ondansetron in preventing postoperative nausea and vomiting after gynaecological laparoscopic surgery. J Int Med Res. 2011;39:399–407.PubMed

42.

Ryu JH, Jeon YT, Hwang JW, Oh AY, Moon JY, Ro YJ, et al. Intravenous, oral, and the combination of intravenous and oral ramosetron for the prevention of nausea and vomiting after laparoscopic cholecystectomy: a randomized, double-blind, controlled trial. Clin Ther. 2011;33:1162–72.PubMed

43.

Sahoo T, SenDasgupta C, Goswami A, Hazra A. Reduction in spinal-induced hypotension with ondansetron in parturients undergoing caesarean section: a double-blind randomised, placebo-controlled study. Int J Obstet Anesth. 2012;21:24–8.PubMed

44.

Bilgin TE, Birbicer H, Ozer Z, Doruk N, Tok E, Oral U. A comparative study of the antiemetic efficacy of dexamethasone, ondansetron, and metoclopramide in patients undergoing gynecological surgery. Med Sci Monit. 2010;16:CR336–341.PubMed

45.

Choi DK, Chin JH, Lee EH, Lim OB, Chung CH, Ro YJ, et al. Prophylactic control of post-operative nausea and vomiting using ondansetron and ramosetron after cardiac surgery. Acta Anaesthesiol Scand. 2010;54:962–9.PubMed

46.

Jee YS, Yoon HJ, Jang CH. Prophylactic antiemetic effects in gynecologic patients receiving fentanyl IV-patient controlled analgesia: comparison of combined treatment with ondansetron and dexamethasone with metoclopramide and dexamethasone. Korean J Anesthesiol. 2010;59:335–9.PubMedPubMedCentral

47.

Jokela R, Ahonen J, Seitsonen E, Marjakangas P, Korttila K. The influence of ondansetron on the analgesic effect of acetaminophen after laparoscopic hysterectomy. Clin Pharmacol Ther. 2010;87:672–8.PubMed

48.

Mehta D, Sanatani S, Whyte SD. The effects of droperidol and ondansetron on dispersion of myocardial repolarization in children. Paediatr Anaesth. 2010;20:905–12.PubMed

49.

Shakya S, Chaturvedi A, Sah BP. Prophylactic low dose ketamine and ondansetron for prevention of shivering during spinal anaesthesia. J Anaesthesiol Clin Pharmacol. 2010;26:465–9.PubMedPubMedCentral

50.

Singla NK, Singla SK, Chung F, Kutsogiannis DJ, Blackburn L, Lane SR, et al. Phase II study to evaluate the safety and efficacy of the oral neurokinin-1 receptor antagonist casopitant (GW679769) administered with ondansetron for the prevention of postoperative and postdischarge nausea and vomiting in high-risk patients. Anesthesiology. 2010;113:74–82.PubMed

51.

Feng PH, Chu KS, Lu IC, Shieh JP, Tzeng JI, Ho ST, et al. Haloperidol plus ondansetron prevents postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy. Acta Anaesthesiol Taiwan. 2009;47:3–9.PubMed

52.

Jain V, Mitra JK, Rath GP, Prabhakar H, Bithal PK, Dash HH. A randomized, double-blinded comparison of ondansetron, granisetron, and placebo for prevention of postoperative nausea and vomiting after supratentorial craniotomy. J Neurosurg Anesthesiol. 2009;21:226–30.PubMed

53.

Riad W, Marouf H. Combination therapy in the prevention of PONV after strabismus surgery in children: granisetron, ondansetron, midazolam with dexamethasone. Middle East J Anesthesiol. 2009;20:431–6.PubMed

54.

Rosow CE, Haspel KL, Smith SE, Grecu L, Bittner EA. Haloperidol versus ondansetron for prophylaxis of postoperative nausea and vomiting. Anesth Analg. 2008;106:1407–9. table of contents.PubMed

55.

Candiotti KA, Kovac AL, Melson TI, Clerici G, Joo Gan T. Palonosetron 04–06 Study G. A randomized, double-blind study to evaluate the efficacy and safety of three different doses of palonosetron versus placebo for preventing postoperative nausea and vomiting. Anesth Analg. 2008;107:445–51.PubMed

56.

Choi YS, Shim JK, Yoon do H, Jeon DH, Lee JY, Kwak YL. Effect of ramosetron on patient-controlled analgesia related nausea and vomiting after spine surgery in highly susceptible patients: comparison with ondansetron. Spine (Phila Pa 1976). 2008;33:E602–6.

57.

Contreras-Dominguez V, Carbonell-Bellolio P. Prophylactic antiemetic therapy for acute abdominal surgery. A comparative study of droperidol, metoclopramide, tropisetron, granisetron and dexamethasone. Rev Bras Anestesiol. 2008;58:35–44.PubMed

58.

Kovac AL, Eberhart L, Kotarski J, Clerici G, Apfel C. Palonosetron 04–07 Study G. A randomized, double-blind study to evaluate the efficacy and safety of three different doses of palonosetron versus placebo in preventing postoperative nausea and vomiting over a 72-hour period. Anesth Analg. 2008;107:439–44.PubMed

59.

Owczuk R, Wenski W, Polak-Krzeminska A, Twardowski P, Arszulowicz R, Dylczyk-Sommer A, et al. Ondansetron given intravenously attenuates arterial blood pressure drop due to spinal anesthesia: a double-blind, placebo-controlled study. Reg Anesth Pain Med. 2008;33:332–9.PubMed

60.

Piper SN, Rohm K, Boldt J, Kranke P, Maleck W, Seifert R, et al. Postoperative nausea and vomiting after surgery for prognathism: not only a question of patients’ comfort. A placebo-controlled comparison of dolasetron and droperidol. J Craniomaxillofac Surg. 2008;36:173–9.PubMed

61.

Said-Ahmed HAF. Does granisetron affect the analgesic efficacy of tramadol in patients undergoing abdominal hysterectomy? Acta Anaesthesiologica Italica. 2008;59:256–66.

62.

Bestas A, Önal SA, Bayar MK, Yildirim A, Aygen E. Effects of ondansetron and granisetron on postoperative nausea and vomiting in adult patients undergoing laparoscopic cholecystectomy: a randomized, double-blind, placebo-controlled clinical trial. Curr Ther Res Clin Exp. 2007;68:303–12.PubMedPubMedCentral

63.

Diemunsch P, Gan TJ, Philip BK, Girao MJ, Eberhart L, Irwin MG, et al. Single-dose aprepitant vs ondansetron for the prevention of postoperative nausea and vomiting: a randomized, double-blind phase III trial in patients undergoing open abdominal surgery. Br J Anaesth. 2007;99:202–11.PubMed

64.

Gan TJ, Apfel CC, Kovac A, Philip BK, Singla N, Minkowitz H, et al. A randomized, double-blind comparison of the NK1 antagonist, aprepitant, versus ondansetron for the prevention of postoperative nausea and vomiting. Anesth Analg. 2007;104:1082–9. tables of contents.PubMed

65.

Han DW, Hong SW, Kwon JY, Lee JW, Kim KJ. Epidural ondansetron is more effective to prevent postoperative pruritus and nausea than intravenous ondansetron in elective cesarean delivery. Acta Obstet Gynecol Scand. 2007;86:683–7.PubMed

66.

Lee Y, Wang PK, Lai HY, Yang YL, Chu CC, Wang JJ. Haloperidol is as effective as ondansetron for preventing postoperative nausea and vomiting. Can J Anaesth. 2007;54:349–54.PubMed

67.

Oksuz H, Zencirci B, Ezberci M. Comparison of the effectiveness of metoclopramide, ondansetron, and granisetron on the prevention of nausea and vomiting after laparoscopic cholecystectomy. J Laparoendosc Adv Surg Tech A. 2007;17:803–8.PubMed

68.

Rusch D, Arndt C, Martin H, Kranke P. The addition of dexamethasone to dolasetron or haloperidol for treatment of established postoperative nausea and vomiting. Anaesthesia. 2007;62:810–7.PubMed

69.

Sagir O, Gulhas N, Toprak H, Yucel A, Begec Z, Ersoy O. Control of shivering during regional anaesthesia: prophylactic ketamine and granisetron. Acta Anaesthesiol Scand. 2007;51:44–9.PubMed

70.

Sandhu T, Tanvatcharaphan P, Cheunjongkolkul V. Ondansetron versus metoclopramide in prophylaxis of nausea and vomiting for laparoscopic cholecystectomy: a prospective double-blind randomized study. Asian J Surg. 2008;31:50–4.PubMed

71.

Siddik-Sayyid SM, Aouad MT, Taha SK, Azar MS, Hakki MA, Kaddoum RN, et al. Does ondansetron or granisetron prevent subarachnoid morphine-induced pruritus after cesarean delivery? Anesth Analg. 2007;104:421–4.PubMed

72.

Bridges JD, Nettle CB, Dugirrala VJ, Suda KJ, Garey KW. Low-dose granisetron for the prevention of postoperative nausea and vomiting. J Appl Res. 2006;6:223–9.

73.

Chan MT, Choi KC, Gin T, Chui PT, Short TG, Yuen PM, et al. The additive interactions between ondansetron and droperidol for preventing postoperative nausea and vomiting. Anesth Analg. 2006;103:1155–62.PubMed

74.

Kelsaka E, Baris S, Karakaya D, Sarihasan B. Comparison of ondansetron and meperidine for prevention of shivering in patients undergoing spinal anesthesia. Reg Anesth Pain Med. 2006;31:40–5.PubMed

75.

Sarvela PJ, Halonen PM, Soikkeli AI, Kainu JP, Korttila KT. Ondansetron and tropisetron do not prevent intraspinal morphine- and fentanyl-induced pruritus in elective cesarean delivery. Acta Anaesthesiol Scand. 2006;50:239–44.PubMed

76.

Tosun Z, Akin A, Dogan H, Boyaci A. A randomized, placebo-controlled trial of a single dose of tropisetron for the prevention of vomiting after strabismus surgery in children. Mt Sinai J Med. 2006;73:1106–11.PubMed

77.

D’Angelo R, Philip B, Gan TJ, Kovac A, Hantler C, Doblar D, et al. A randomized, double-blind, close-ranging, pilot study of intravenous granisetron in the prevention of postoperative nausea and vomiting in patients abdominal hysterectomy. Eur J Anaesthesiol. 2005;22:774–9.PubMed

78.

Gan TJ, Coop A, Philip BK. A randomized, double-blind study of granisetron plus dexamethasone versus ondansetron plus dexamethasone to prevent postoperative nausea and vomiting in patients undergoing abdominal hysterectomy. Anesth Analg. 2005;101:1323–9.PubMed

79.

Khalil SN, Roth AG, Cohen IT, Simhi E, Ansermino JM, Bolos ME, et al. A double-blind comparison of intravenous ondansetron and placebo for preventing postoperative emesis in 1- to 24-month-old pediatric patients after surgery under general anesthesia. Anesth Analg. 2005;101:356–61. table of contents.PubMed

80.

Kocamanoglu IS, Baris S, Karakaya D, Sener B, Tur A, Cetinkaya M. Effects of granisetron with droperidol or dexamethasone on prevention of postoperative nausea and vomiting after general anesthesia for cesarean section. Methods Find Exp Clin Pharmacol. 2005;27:489–93.PubMed

81.

Kontrimaviciute E, Baublys A, Ivaskevicius J. Postoperative nausea and vomiting in patients undergoing total abdominal hysterectomy under spinal anaesthesia: a randomized study of ondansetron prophylaxis. Eur J Anaesthesiol. 2005;22:504–9.PubMed

82.

Pirat A, Tuncay SF, Torgay A, Candan S, Arslan G. Ondansetron, orally disintegrating tablets versus intravenous injection for prevention of intrathecal morphine-induced nausea, vomiting, and pruritus in young males. Anesth Analg. 2005;101:1330–6.PubMed

83.

Treschan TA, Zimmer C, Nass C, Stegen B, Esser J, Peters J. Inspired oxygen fraction of 0.8 does not attenuate postoperative nausea and vomiting after strabismus surgery. Anesthesiology. 2005;103:6–10.PubMed

84.

White PF, Scuderi PE. Prevention of postoperative nausea and vomiting (PONV): A dose-ranging study involving palonosetron, a potent 5-HT3 receptor antagonist. Anesthesiology. 2005;103:A703.

85.

Apfel CC, Korttila K, Abdalla M, Kerger H, Turan A, Vedder I, et al. A factorial trial of six interventions for the prevention of postoperative nausea and vomiting. N Engl J Med. 2004;350:2441–51.PubMedPubMedCentral

86.

Binstock W, Rubin R, Bachman C, Kahana M, McDade W, Lynch JP. The effect of premedication with OTFC, with or without ondansetron, on postoperative agitation, and nausea and vomiting in pediatric ambulatory patients. Paediatr Anaesth. 2004;14:759–67.PubMed

87.

Eberhart LH, Morin AM, Hoerle S, Wulf H, Geldner G. Droperidol and dolasetron alone or in combination for prevention of postoperative nausea and vomiting after vitrectomy. Ophthalmology. 2004;111:1569–75.PubMed

88.

Hanaoka K, Toyooka H, Kugimiya T, Ohashi Y. Granisetron Study Group of Japan. Efficacy of prophylactic intravenous granisetron in postoperative emesis in adults. J Anesth. 2004;18:158–65.PubMed

89.

Samarkandi AH, Riad W, Altaf R, Fatani R. Dexamethasone-ondansetron combination in prevention of nausea and vomiting after strabismus surgery in children. Egypt J Anaesth. 2004;20:399–403.

90.

Charuluxananan S, Kyokong O, Somboonviboon W, Narasethakamol A, Promlok P. Nalbuphine versus ondansetron for prevention of intrathecal morphine-induced pruritus after cesarean delivery. Anesth Analg. 2003;96:1789–93. table of contents.PubMed

91.

Loewen P, Lamb S, Clugston P. Randomized, double-blind trial of dolasetron versus droperidol for prophylaxis of postoperative nausea and vomiting in patients undergoing TRAM flap breast reconstruction surgery. Ann Plast Surg. 2003;51:472–7.PubMed

92.

O’Brien CM, Titley G, Whitehurst P. A comparison of cyclizine, ondansetron and placebo as prophylaxis against postoperative nausea and vomiting in children. Anaesthesia. 2003;58:707–11.PubMed

93.

Argiriadou H, Papaziogas B, Pavlidis T, Parlapani A, Georgiou M, Papagiannopoulou P, et al. Tropisetron vs ondansetron for prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy: a randomized double-blind, placebo-controlled study. Surg Endosc. 2002;16:1087–90.PubMed

94.

Gurkan Y, Toker K. Prophylactic ondansetron reduces the incidence of intrathecal fentanyl-induced pruritus. Anesth Analg. 2002;95:1763–6. table of contents.PubMed

95.

Dabbous A, Khoury SJ, Chehab IR, Bartelmaos T, Khoury G. Ondansetron versus dehydrobenzoperidol and metoclopramide for management of postoperative nausea in laparoscopic surgery patients. JSLS. 2001;5:139–42.PubMedPubMedCentral

96.

Kathirvel S, Dash HH, Bhatia A, Subramaniam B, Prakash A, Shenoy S. Effect of prophylactic ondansetron on postoperative nausea and vomiting after elective craniotomy. J Neurosurg Anesthesiol. 2001;13:207–12.PubMed

97.

Subramaniam B, Madan R, Sadhasivam S, Sennaraj B, Tamilselvan P, Rajeshwari S, et al. Dexamethasone is a cost-effective alternative to ondansetron in preventing PONV after paediatric strabismus repair. Br J Anaesth. 2001;86:84–9.PubMed

98.

Ahmed AB, Hobbs GJ, Curran JP. Randomized, placebo-controlled trial of combination antiemetic prophylaxis for day-case gynaecological laparoscopic surgery. Br J Anaesth. 2000;85:678–82.PubMed

99.

Charuluxananan S, Somboonviboon W, Kyokong O, Nimcharoendee K. Ondansetron for treatment of intrathecal morphine-induced pruritus after cesarean delivery. Reg Anesth Pain Med. 2000;25:535–9.PubMed

100.

Jensen AB, Christiansen DB, Coulthard K, Wilkins A, Roberts G, Walt JH, et al. Tropisetron reduces postoperative vomiting in children undergoing tonsillectomy. Paediatr Anaesth. 2000;10:69–75.PubMed

101.

Kreisler NS, Spiekermann BF, Ascari CM, Rhyne HA, Kloth RL, Sullivan LM, et al. Small-dose droperidol effectively reduces nausea in a general surgical adult patient population. Anesth Analg. 2000;91:1256–61.PubMed

102.

Philip BK, Pearman MH, Kovac AL, Chelly JE, Wetchler BV, McKenzie R, et al. Dolasetron for the prevention of postoperative nausea and vomiting following outpatient surgery with general anaesthesia: a randomized, placebo-controlled study. The Dolasetron PONV Prevention Study Group. Eur J Anaesthesiol. 2000;17:23–32.PubMed

103.

Zarate E, Watcha MF, White PF, Klein KW, Sa Rego M, Stewart DG. A comparison of the costs and efficacy of ondansetron versus dolasetron for antiemetic prophylaxis. Anesth Analg. 2000;90:1352–8.PubMed

104.

Koivuranta M, Ala-Kokko TI, Jokela R, Ranta P. Comparison of ondansetron and tropisetron combined with droperidol for the prevention of emesis in women with a history of post-operative nausea and vomiting. Eur J Anaesthesiol. 1999;16:390–5.PubMed

105.

McCall JE, Stubbs K, Saylors S, Pohlman S, Ivers B, Smith S, et al. The search for cost-effective prevention of postoperative nausea and vomiting in the child undergoing reconstructive burn surgery: ondansetron versus dimenhydrinate. J Burn Care Rehabil. 1999;20:309–15.PubMed

106.

Sinha PK, Tripathi M, Ambesh SP. Efficacy of ondansetron in prophylaxis of postoperative nausea and vomiting in patients following infratentorial surgery: a placebo-controlled prospective double-blind study. J Neurosurg Anesthesiol. 1999;11:6–10.PubMed

107.

Tsui SL, Ng KF, Wong LC, Tang GW, Pun TC, Yang JC. Prevention of postoperative nausea and vomiting in gynaecological laparotomies: a comparison of tropisetron and ondansetron. Anaesth Intensive Care. 1999;27:471–6.PubMed

108.

Diemunsch P, Korttila K, Leeser J, Helmers JH, Wilkey B, Nave S, et al. Oral dolasetron mesylate for prevention of postoperative nausea and vomiting: a multicenter, double-blind, placebo-controlled study. The Oral Dolasetron PONV Prevention Study Group. J Clin Anesth. 1998;10:145–52.PubMed

109.

Goodarzi M. A double blind comparison of droperidol and ondansetron for prevention of emesis in children undergoing orthopaedic surgery. Paediatr Anaesth. 1998;8:325–9.PubMed

110.

Hamid SK, Selby IR, Sikich N, Lerman J. Vomiting after adenotonsillectomy in children: a comparison of ondansetron, dimenhydrinate, and placebo. Anesth Analg. 1998;86:496–500.PubMed

111.

Morris RW, Aune H, Feiss P, Hanson A, Hasselstrom L, Maltby JR, et al. International, multicentre, placebo-controlled study to evaluate the effectiveness of ondansetron vs. metoclopramide in the prevention of post-operative nausea and vomiting. Eur J Anaesthesiol. 1998;15:69–79.PubMed

112.

Scholz J, Hennes HJ, Steinfath M, Farber L, Schweiger C, Dick W, et al. Tropisetron or ondansetron compared with placebo for prevention of postoperative nausea and vomiting. Eur J Anaesthesiol. 1998;15:676–85.PubMed

113.

Tramer MR, Sansonetti A, Fuchs-Buder T, Rifat K. Oculocardiac reflex and postoperative vomiting in paediatric strabismus surgery. A randomised controlled trial comparing four anaesthetic techniques. Acta Anaesthesiol Scand. 1998;42:117–23.PubMed

114.

Diemunsch P, D’Hollander A, Paxton L, Schoeffler P, Wessel P, Nave S, et al. Intravenous dolasetron mesilate in the prevention of postoperative nausea and vomiting in females undergoing gynecological surgery. J Clin Anesth. 1997;9:365–73.PubMed

115.

Diemunsch P, Leeser J, Feiss P, D’Hollander A, Bradburn BG, Paxton D, et al. Intravenous dolasetron mesilate ameliorates postoperative nausea and vomiting. Can J Anaesth. 1997;44:173–81.PubMed

116.

Graczyk SG, McKenzie R, Kallar S, Hickok CB, Melson T, Morrill B, et al. Intravenous dolasetron for the prevention of postoperative nausea and vomiting after outpatient laparoscopic gynecologic surgery. Anesth Analg. 1997;84:325–30.PubMed

117.

Klockgether-Radke A, Neumann S, Neumann P, Braun U, Muhlendyck H. Ondansetron, droperidol and their combination for the prevention of post-operative vomiting in children. Eur J Anaesthesiol. 1997;14:362–7.PubMed

118.

Koivuranta M, Laara E, Ranta P, Ravaska P, Alahuhta S. Comparison of ondansetron and droperidol in the prevention of postoperative nausea and vomiting after laparoscopic surgery in women. A randomised, double-blind, placebo-controlled trial. Acta Anaesthesiol Scand. 1997;41:1273–9.PubMed

119.

Korttila K, Clergue F, Leeser J, Feiss P, Olthoff D, Payeur-Michel C, et al. Intravenous dolasetron and ondansetron in prevention of postoperative nausea and vomiting: a multicenter, double-blind, placebo-controlled study. Acta Anaesthesiol Scand. 1997;41:914–22.PubMed

120.

Kovac AL, Scuderi PE, Boerner TF, Chelly JE, Goldberg ME, Hantler CB, et al. Treatment of postoperative nausea and vomiting with single intravenous doses of dolasetron mesylate: a multicenter trial. Dolasetron Mesylate PONV Treatment Study Group. Anesth Analg. 1997;85:546–52.PubMed

121.

Mikawa K, Takao Y, Nishina K, Shiga M, Maekawa N, Obara H. Optimal dose of granisetron for prophylaxis against postoperative emesis after gynecological surgery. Anesth Analg. 1997;85:652–6.PubMed

122.

Monagle J, Barnes R, Goodchild C, Hewitt M. Ondansetron is not superior to moderate dose metoclopramide in the prevention of post-operative nausea and vomiting after minor gynaecological surgery. Eur J Anaesthesiol. 1997;14:604–9.PubMed

123.

Morton NS, Camu F, Dorman T, Knudsen KE, Kvalsvik O, Nellgard P, et al. Ondansetron reduces nausea and vomiting after paediatric adenotonsillectomy. Paediatr Anaesth. 1997;7:37–45.PubMed

124.

Patel RI, Davis PJ, Orr RJ, Ferrari LR, Rimar S, Hannallah RS, et al. Single-dose ondansetron prevents postoperative vomiting in pediatric outpatients. Anesth Analg. 1997;85:538–45.PubMed

125.

Purhonen S, Kauko M, Koski EM, Nuutinen L. Comparison of tropisetron, droperidol, and saline in the prevention of postoperative nausea and vomiting after gynecologic surgery. Anesth Analg. 1997;84:662–7.PubMed

126.

Rung GW, Claybon L, Hord A, Patel C, Kallgren M, Koppel J, et al. Intravenous ondansetron for postsurgical opioid-induced nausea and vomiting. S3A-255 Study Group. Anesth Analg. 1997;84:832–8.PubMed

127.

Scuderi PE, Weaver Jr RG, James RL, Mims G, Elliott WG, Weeks DB. A randomized, double-blind, placebo controlled comparison of droperidol, ondansetron, and metoclopramide for the prevention of vomiting following outpatient strabismus surgery in children. J Clin Anesth. 1997;9:551–8.PubMed

128.

Taylor AM, Rosen M, Diemunsch PA, Thorin D, Houweling PL. A double-blind, parallel-group, placebo-controlled, dose-ranging, multicenter study of intravenous granisetron in the treatment of postoperative nausea and vomiting in patients undergoing surgery with general anesthesia. J Clin Anesth. 1997;9:658–63.PubMed

129.

Ulusoy HO, Akturk G, Luleci N, Kalac N, Albayrak D. Prophylactic administration of ondansetron in emergency intraabdominal operations. Middle East J Anesthesiol. 1997;14:45–58.PubMed

130.

Warriner CB, Knox D, Belo S, Cole C, Finegan BA, Perreault L. Prophylactic oral dolasetron mesylate reduces nausea and vomiting after abdominal hysterectomy. The Canadian Dolasetron Study Group. Can J Anaesth. 1997;44:1167–73.PubMed

131.

Ali-Melkkila T, Kanto J, Katevuo R. Tropisetron and metoclopramide in the prevention of postoperative nausea and vomiting. A comparative, placebo controlled study in patients undergoing ophthalmic surgery. Anaesthesia. 1996;51:232–5.PubMed

132.

Capouet V, De Pauw C, Vernet B, Ivens D, Derijcke V, Versichelen L, et al. Single dose i.v. tropisetron in the prevention of postoperative nausea and vomiting after gynaecological surgery. Br J Anaesth. 1996;76:54–60.PubMed

133.

Kovac AL, Pearman MH, Khalil SN, Scuderi PE, Joslyn AF, Prillaman BA, et al. Ondansetron prevents postoperative emesis in male outpatients. S3A-379 Study Group. J Clin Anesth. 1996;8:644–51.PubMed

134.

Naguib M, el Bakry AK, Khoshim MH, Channa AB, el Gammal M, el Gammal K, et al. Prophylactic antiemetic therapy with ondansetron, tropisetron, granisetron and metoclopramide in patients undergoing laparoscopic cholecystectomy: a randomized, double-blind comparison with placebo. Can J Anaesth. 1996;43:226–31.PubMed

135.

Desilva PH, Darvish AH, McDonald SM, Cronin MK, Clark K. The efficacy of prophylactic ondansetron, droperidol, perphenazine, and metoclopramide in the prevention of nausea and vomiting after major gynecologic surgery. Anesth Analg. 1995;81:139–43.PubMed

136.

Litman RS, Wu CL, Lee A, Griswold JD, Voisine R, Marshall C. Prevention of emesis after strabismus repair in children: a prospective, double-blinded, randomized comparison of droperidol versus ondansetron. J Clin Anesth. 1995;7:58–62.PubMed

137.

Paech MJ, Pavy TJ, Evans SF. Single-dose prophylaxis for postoperative nausea and vomiting after major abdominal surgery: ondansetron versus droperidol. Anaesth Intensive Care. 1995;23:548–54.PubMed

138.

Paxton D, Taylor RH, Gallagher TM, Crean PM. Postoperative emesis following otoplasty in children. Anaesthesia. 1995;50:1083–5.PubMed

139.

Kaufmann MA, Rosow C, Schnieper P, Schneider M. Prophylactic antiemetic therapy with patient-controlled analgesia: a double-blind, placebo-controlled comparison of droperidol, metoclopramide, and tropisetron. Anesth Analg. 1994;78:988–94.PubMed

140.

Ummenhofer W, Frei FJ, Urwyler A, Kern C, Drewe J. Effects of ondansetron in the prevention of postoperative nausea and vomiting in children. Anesthesiology. 1994;81:804–10.PubMed

141.

Dupeyron JP, Conseiller C, Levarlet M, Hemmingsen C, Schoeffler P, Pedersen FM, et al. The effect of oral ondansetron in the prevention of postoperative nausea and vomiting after major gynaecological surgery performed under general anaesthesia. Anaesthesia. 1993;48:214–8.PubMed

142.

Helmers JH, Briggs L, Abrahamsson J, Soni J, Moodley J, Forrler M, et al. A single i.v. dose of ondansetron 8 mg prior to induction of anaesthesia reduces postoperative nausea and vomiting in gynaecological patients. Can J Anaesth. 1993;40:1155–61.PubMed

143.

Raphael JH, Norton AC. Antiemetic efficacy of prophylactic ondansetron in laparoscopic surgery: randomized, double-blind comparison with metoclopramide. Br J Anaesth. 1993;71:845–8.PubMed

144.

Du Pen S, Scuderi P, Wetchler B, Sung YF, Mingus M, Clayborn L, et al. Ondansetron in the treatment of postoperative nausea and vomiting in ambulatory outpatients: a dose-comparative, stratified, multicentre study. Eur J Anaesthesiol Suppl. 1992;6:55–62.PubMed

145.

Charbit B, Albaladejo P, Funck-Brentano C, Legrand M, Samain E, Marty J. Prolongation of QTc interval after postoperative nausea and vomiting treatment by droperidol or ondansetron. Anesthesiology. 2005;102:1094–100.PubMed

146.

Kovac A, McKenzie R, O’Connor T, Duncalf D, Angel J, Gratz I, et al. Prophylactic intravenous ondansetron in female outpatients undergoing gynaecological surgery: a multicentre dose-comparison study. Eur J Anaesthesiol Suppl. 1992;6:37–47.PubMed

147.

Lerman J, Sims C, Sikich N, Gow R, Chin C, Dempsey E, et al. Pharmacokinetics of the active metabolite (MDL 74,156) of dolasetron mesylate after oral or intravenous administration to anesthetized children. Clin Pharmacol Ther. 1996;60:485–92.PubMed

148.

Wagner DS, Gauger V, Chiravuri D, Faust K. Ondansetron oral disintegrating tablets for the prevention of postoperative vomiting in children undergoing strabismus surgery. Ther Clin Risk Manag. 2007;3:691–4.PubMedPubMedCentral

149.

Rose JB, Brenn BR, Corddry DH, Thomas PC. Preoperative oral ondansetron for pediatric tonsillectomy. Anesth Analg. 1996;82:558–62.PubMed

150.

El-Deeb A, Abd el motlb E. Prophylactic multimodal antiemetic in women undergoing cesarean section under spinal anesthesia. Egypt J Anaesth. 2011;27:107–11.

151.

Jokela RM, Cakmakkaya OS, Danzeisen O, Korttila KT, Kranke P, Malhotra A, et al. Ondansetron has similar clinical efficacy against both nausea and vomiting. Anaesthesia. 2009;64:147–51.PubMed

152.

Pearman MH. Single dose intravenous ondansetron in the prevention of postoperative nausea and vomiting. Anaesthesia. 1994;49:11–5.PubMed

153.

Scuderi P, Wetchler B, Sung YF, Mingus M, DuPen S, Claybon L, et al. Treatment of postoperative nausea and vomiting after outpatient surgery with the 5-HT3 antagonist ondansetron. Anesthesiology. 1993;78:15–20.PubMed

154.

McKenzie R, Kovac A, O’Connor T, Duncalf D, Angel J, Gratz I, et al. Comparison of ondansetron versus placebo to prevent postoperative nausea and vomiting in women undergoing ambulatory gynecologic surgery. Anesthesiology. 1993;78:21–8.PubMed

155.

Bagameri A, Bosze P. Ondansetron (Zofran) treatment of chemotherapy induced nausea and vomiting in patients with gynecological malignancies. Magy Noorv Lapja. 1994;57:291–3.

156.

Chen LK, Fan SZ, Huang CH, Chao A, Cherng YG, Chen CL, et al. Effects of ondansetron on postoperative emesis in Chinese children. Acta Anaesthesiol Sin. 1998;36:87–91.PubMed

157.

Ebrahim Soltani AR, Mohammadinasab H, Goudarzi M, Arbabi S, Mohammadinasab A, Mohammadinasab F, et al. Comparing the efficacy of prophylactic p6 acupressure, ondansetron, metoclopramide and placebo in the prevention of vomiting and nausea after strabismus surgery. Acta Med Iran. 2011;49:208–12.PubMed

158.

Ng WW, Li AC, Lee DW, Leung TL, Ko CW, Leung KF, et al. Effectiveness of Ondansetron to prevent postoperative nausea and vomiting in ambulatory two port needlescopic cholecystectomy: a randomised controlled trial. Ambul Surg. 2008;14:1–14.

159.

Aouad MT, Siddik-Sayyid SM, Taha SK, Azar MS, Nasr VG, Hakki MA, et al. Haloperidol vs. ondansetron for the prevention of postoperative nausea and vomiting following gynaecological surgery. Eur J Anaesthesiol. 2007;24:171–8.PubMed

160.

Freedman SB, Uleryk E, Rumantir M, Finkelstein Y. Ondansetron and the risk of cardiac arrhythmias: a systematic review and postmarketing analysis. Ann Emerg Med. 2014;64:19–25.PubMed

161.

Rawlinson A, Kitchingham N, Hart C, McMahon G, Ong SL, Khanna A. Mechanisms of reducing postoperative pain, nausea and vomiting: a systematic review of current techniques. Evid Based Med. 2012;17:75–80.PubMed

162.

Tricco A, Veroniki A, Blondal E, Hamid J, Straus S. Incorporating dosages increases the relevance of network meta-analysis for decision-makers: A case example using data from a systematic review of serotonin (5-HT3) receptor antagonists in patients undergoing surgery. Toronto: Canadian Association of Pharmacy Technicians (CAPT) Conference; 2014.

Title: Comparative safety of serotonin (5-HT3) receptor antagonists in patients undergoing surgery: a systematic review and network meta-analysis
Authors: Andrea C Tricco
Charlene Soobiah
Erik Blondal
Areti A Veroniki
Paul A Khan
Afshin Vafaei
John Ivory
Lisa Strifler
Huda Ashoor
Heather MacDonald
Emily Reynen
Reid Robson
Joanne Ho
Carmen Ng
Jesmin Antony
Kelly Mrklas
Brian Hutton
Brenda R Hemmelgarn
David Moher
Sharon E Straus
Publication date: 01-12-2015
Publisher: BioMed Central
Published in: BMC Medicine / Issue 1/2015
Electronic ISSN: 1741-7015
DOI: https://doi.org/10.1186/s12916-015-0379-3

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Comparative safety of serotonin (5-HT₃) receptor antagonists in patients undergoing surgery: a systematic review and network meta-analysis

Abstract

Background

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

Please log in to get access to this content

Other articles of this Issue 1/2015

Integrating vector control across diseases

An adjustable fetal weight standard for twins: a statistical modeling study

Real-time characterization of risks of death associated with the Middle East respiratory syndrome (MERS) in the Republic of Korea, 2015

Implementing supported self-management for asthma: a systematic review and suggested hierarchy of evidence of implementation studies

Colorectal cancer screening: the time to act is now

The role of a hepatitis C virus vaccine: modelling the benefits alongside direct-acting antiviral treatments