Skip to main content
Top
Published in: BMC Health Services Research 1/2019

Open Access 01-12-2019 | Hepatitis C | Research article

Short-term budget affordability of hepatitis C treatments for state Medicaid programs

Authors: Jacquelyn W. Chou, Alison R. Silverstein, Dana P. Goldman

Published in: BMC Health Services Research | Issue 1/2019

Login to get access

Abstract

Background

With some Medicaid state programs still restricting patient access to hepatitis C (HCV) treatment, it is important to demonstrate how states could expand treatment access to a broader Medicaid population and balance short-term budget concerns.

Methods

We used the HCV Transmission and Progression (TaP) Markov model to quantify the impact of removing restrictions to HCV treatment access on the infected populations, expenditures, and net social value for the North Carolina (NC), Oregon (OR), and Wisconsin (WI) Medicaid programs. Four HCV treatment access scenarios were modeled: 1) Baseline: Patients were treated according to Medicaid disease severity and sobriety requirements in 2015; 2) Remove Sobriety Restrictions: Disease severity restrictions were maintained, but people who inject drugs (PWID) were given access to treatment; 3) Treat Early: All patients, except for PWIDs, regardless of disease severity, were eligible for treatment and the diagnosis rate increased from 50 to 66%; and 4) Remove Access Restrictions: all patients, regardless of disease severity and sobriety, were eligible for treatment. Our key model outputs were: number of infected Medicaid beneficiaries, HCV-related medical and treatment expenditures, total social value, and state Medicaid spending over 10 years.

Results

Across all three states, removing access restrictions resulted in the greatest benefits over 10 years (net social value relative to baseline = $408 M in NC; $408 M in OR; $271 M in WI) and the smallest infected population (5200 in NC; 2000 in OR; 614 in WI). Reduced disease transmission resulted in lower health care expenditures (-$66 M in NC; -$50 M in OR; -$54 M in WI). All of the expanded treatment access policies achieved break-even costs—where total treatment and health care expenditures fell below those of Baseline—in 4 to 8 years. Removing access restrictions yielded the greatest improvement in social value (net of medical expenditures and treatment costs, QALYs valued at $150 K per QALY).

Conclusions

While increasing treatment access in Medicaid will raise short-term costs, it will also provide clear benefits relatively quickly by saving money and improving health within a 10-year window. Patients and taxpayers would benefit by considering these gains and taking a more expansive and long-term view of HCV treatment policies.
Appendix
Available only for authorised users
Literature
3.
go back to reference Afdhal NH. The natural history of hepatitis C. In: Seminars in liver disease: 2004: copyright© 2004 by Thieme medical publishers, Inc., 333 seventh avenue, New York, NY 10001, USA; 2004. p. 3–8. Afdhal NH. The natural history of hepatitis C. In: Seminars in liver disease: 2004: copyright© 2004 by Thieme medical publishers, Inc., 333 seventh avenue, New York, NY 10001, USA; 2004. p. 3–8.
4.
go back to reference Center for Medicaid and CHIP Services: Assuring Medicaid beneficiaries access to Hepatitis C (HCV) drugs. In. Edited by Centers for Medicare and Medicaid Services. Baltimore, MD: Department of Health and Human Services; 2015. Center for Medicaid and CHIP Services: Assuring Medicaid beneficiaries access to Hepatitis C (HCV) drugs. In. Edited by Centers for Medicare and Medicaid Services. Baltimore, MD: Department of Health and Human Services; 2015.
6.
go back to reference Hepatitis C: The State of Medicaid 2017 National Summary Report [https://www.chlpi.org/wp-content/uploads/2013/12/State-of-HepC_2017_FINAL.pdf]. Hepatitis C: The State of Medicaid 2017 National Summary Report [https://​www.​chlpi.​org/​wp-content/​uploads/​2013/​12/​State-of-HepC_​2017_​FINAL.​pdf].
8.
go back to reference Moreno GA, Mulligan K, Huber C, Linthicum MT, Dreyfus D, Juday T, Marx SE, Gonzalez YS, Brookmeyer R, Lakdawalla DN: Costs and spillover effects of private insurers' coverage of hepatitis C treatment. Am J Manag Care 2016, 22(6 Spec No.):SP236–244. Moreno GA, Mulligan K, Huber C, Linthicum MT, Dreyfus D, Juday T, Marx SE, Gonzalez YS, Brookmeyer R, Lakdawalla DN: Costs and spillover effects of private insurers' coverage of hepatitis C treatment. Am J Manag Care 2016, 22(6 Spec No.):SP236–244.
9.
go back to reference Johnson RL, Blumen H, Ferro C: The burden of hepatitis C virus disease in commercial and managed Medicaid populations. In.; 2015. Johnson RL, Blumen H, Ferro C: The burden of hepatitis C virus disease in commercial and managed Medicaid populations. In.; 2015.
12.
go back to reference Chidi AP, Bryce CL, Donohue JM, Fine MJ, Landsittel DP, Myaskovsky L, Rogal SS, Switzer GE, Tsung A, Smith KJ. Economic and public health impacts of policies restricting access to hepatitis C treatment for medicaid patients. Value Health. 2016;19(4):326–34.CrossRef Chidi AP, Bryce CL, Donohue JM, Fine MJ, Landsittel DP, Myaskovsky L, Rogal SS, Switzer GE, Tsung A, Smith KJ. Economic and public health impacts of policies restricting access to hepatitis C treatment for medicaid patients. Value Health. 2016;19(4):326–34.CrossRef
13.
go back to reference Younossi Z, Gordon SC, Ahmed A, Dieterich D, Saab S, Beckerman R. Treating Medicaid patients with hepatitis C: clinical and economic impact. Am J Manag Care. 2017;23(2):107–12.PubMed Younossi Z, Gordon SC, Ahmed A, Dieterich D, Saab S, Beckerman R. Treating Medicaid patients with hepatitis C: clinical and economic impact. Am J Manag Care. 2017;23(2):107–12.PubMed
14.
go back to reference Van Nuys K, Brookmeyer R, Chou JW, Dreyfus D, Dieterich D, Goldman DP. Broad hepatitis C treatment scenarios return substantial health gains, but capacity is a concern. Health Aff. 2015;34(10):1666–74.CrossRef Van Nuys K, Brookmeyer R, Chou JW, Dreyfus D, Dieterich D, Goldman DP. Broad hepatitis C treatment scenarios return substantial health gains, but capacity is a concern. Health Aff. 2015;34(10):1666–74.CrossRef
16.
go back to reference Manos MM, Shvachko VA, Murphy RC, Arduino JM, Shire NJ. Distribution of hepatitis C virus genotypes in a diverse US integrated health care population. J Med Virol. 2012;84(11):1744–50.CrossRef Manos MM, Shvachko VA, Murphy RC, Arduino JM, Shire NJ. Distribution of hepatitis C virus genotypes in a diverse US integrated health care population. J Med Virol. 2012;84(11):1744–50.CrossRef
18.
go back to reference Kanwal F, Kramer JR, Ilyas J, Duan Z, El-Serag HB. HCV genotype 3 is associated with an increased risk of cirrhosis and hepatocellular cancer in a national sample of U.S. veterans with HCV. Hepatology. 2014;60(1):98–105.CrossRef Kanwal F, Kramer JR, Ilyas J, Duan Z, El-Serag HB. HCV genotype 3 is associated with an increased risk of cirrhosis and hepatocellular cancer in a national sample of U.S. veterans with HCV. Hepatology. 2014;60(1):98–105.CrossRef
19.
go back to reference Probst A, Dang T, Bochud M, Egger M, Negro F, Bochud PY. Role of hepatitis C virus genotype 3 in liver fibrosis progression--a systematic review and meta-analysis. J Viral Hepat. 2011;18(11):745–59.CrossRef Probst A, Dang T, Bochud M, Egger M, Negro F, Bochud PY. Role of hepatitis C virus genotype 3 in liver fibrosis progression--a systematic review and meta-analysis. J Viral Hepat. 2011;18(11):745–59.CrossRef
20.
go back to reference McCombs J, Matsuda T, Tonnu-Mihara I, Saab S, Hines P, L'Italien G, Juday T, Yuan Y. The risk of long-term morbidity and mortality in patients with chronic hepatitis C: results from an analysis of data from a Department of Veterans Affairs Clinical Registry. JAMA Intern Med. 2014;174(2):204–12.CrossRef McCombs J, Matsuda T, Tonnu-Mihara I, Saab S, Hines P, L'Italien G, Juday T, Yuan Y. The risk of long-term morbidity and mortality in patients with chronic hepatitis C: results from an analysis of data from a Department of Veterans Affairs Clinical Registry. JAMA Intern Med. 2014;174(2):204–12.CrossRef
21.
go back to reference North Carolina Division of Public Health: Hepatitis C in North Carolina: Two Epidemics with One Public Health Response. In.; 2016. North Carolina Division of Public Health: Hepatitis C in North Carolina: Two Epidemics with One Public Health Response. In.; 2016.
22.
go back to reference Oregon Health Authority: Viral Hepatitis in Oregon. In.; 2015. Oregon Health Authority: Viral Hepatitis in Oregon. In.; 2015.
23.
go back to reference Wisconsin Department of Health Services: Epidemiologic Profile of Hepatitis C Virus (HCV) in Wisconsin 2014. In.; 2014. Wisconsin Department of Health Services: Epidemiologic Profile of Hepatitis C Virus (HCV) in Wisconsin 2014. In.; 2014.
24.
go back to reference Klevens RM, Liu S, Roberts H, Jiles RB, Holmberg SD. Estimating acute viral hepatitis infections from nationally reported cases. Am J Public Health. 2014;104(3):482–7.CrossRef Klevens RM, Liu S, Roberts H, Jiles RB, Holmberg SD. Estimating acute viral hepatitis infections from nationally reported cases. Am J Public Health. 2014;104(3):482–7.CrossRef
25.
go back to reference Rosenberg ES, Hall EW, Sullivan PS, Sanchez TH, Workowski KA, Ward JW, Holtzman D. Estimation of state-level prevalence of Hepatitis C virus infection, US states and District of Columbia, 2010. Clin Infect Dis. 2017;64(11):1573–81.CrossRef Rosenberg ES, Hall EW, Sullivan PS, Sanchez TH, Workowski KA, Ward JW, Holtzman D. Estimation of state-level prevalence of Hepatitis C virus infection, US states and District of Columbia, 2010. Clin Infect Dis. 2017;64(11):1573–81.CrossRef
26.
go back to reference Denniston MM, Jiles RB, Drobeniuc J, Klevens RM, Ward JW, McQuillan GM, Holmberg SD. Chronic hepatitis C virus infection in the United States, National Health and nutrition examination survey 2003 to 2010. Ann Intern Med. 2014;160(5):293–300.CrossRef Denniston MM, Jiles RB, Drobeniuc J, Klevens RM, Ward JW, McQuillan GM, Holmberg SD. Chronic hepatitis C virus infection in the United States, National Health and nutrition examination survey 2003 to 2010. Ann Intern Med. 2014;160(5):293–300.CrossRef
27.
go back to reference Congressional Budget Office: Competition and the Cost of Medicare's Prescription Drug Program. In.; 2014. Congressional Budget Office: Competition and the Cost of Medicare's Prescription Drug Program. In.; 2014.
28.
go back to reference Sapatkin D. In major shift, Pa. To expand hepatitis C treatment for Medicaid patients. In: The inquirer. Philadelphia: PA. p. 2017. Sapatkin D. In major shift, Pa. To expand hepatitis C treatment for Medicaid patients. In: The inquirer. Philadelphia: PA. p. 2017.
29.
go back to reference Grabowski HG, Vernon JM. Brand loyalty, entry, and price competition in pharmaceuticals after the 1984 drug act. J Law Econ. 1992;35(2):331–50.CrossRef Grabowski HG, Vernon JM. Brand loyalty, entry, and price competition in pharmaceuticals after the 1984 drug act. J Law Econ. 1992;35(2):331–50.CrossRef
30.
go back to reference Hirth RA, Chernew ME, Miller E, Fendrick AM, Weissert WG. Willingness to pay for a quality-adjusted life year: in search of a standard. Med Decis Mak. 2000;20(3):332–42.CrossRef Hirth RA, Chernew ME, Miller E, Fendrick AM, Weissert WG. Willingness to pay for a quality-adjusted life year: in search of a standard. Med Decis Mak. 2000;20(3):332–42.CrossRef
32.
go back to reference Manns MP, McHutchison JG, Gordon SC, Rustgi VK, Shiffman M, Reindollar R, Goodman ZD, Koury K, Ling M-H, Albrecht JK. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet. 2001;358(9286):958–65.CrossRef Manns MP, McHutchison JG, Gordon SC, Rustgi VK, Shiffman M, Reindollar R, Goodman ZD, Koury K, Ling M-H, Albrecht JK. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet. 2001;358(9286):958–65.CrossRef
Metadata
Title
Short-term budget affordability of hepatitis C treatments for state Medicaid programs
Authors
Jacquelyn W. Chou
Alison R. Silverstein
Dana P. Goldman
Publication date
01-12-2019
Publisher
BioMed Central
Keyword
Hepatitis C
Published in
BMC Health Services Research / Issue 1/2019
Electronic ISSN: 1472-6963
DOI
https://doi.org/10.1186/s12913-019-3956-x

Other articles of this Issue 1/2019

BMC Health Services Research 1/2019 Go to the issue