Skip to main content
Top
Published in: BMC Health Services Research 1/2019

Open Access 01-12-2019 | Research article

The Harvard medical practice study trigger system performance in deceased patients

Authors: Dorthe O. Klein, Roger J. M. W. Rennenberg, Richard P. Koopmans, Martin H. Prins

Published in: BMC Health Services Research | Issue 1/2019

Login to get access

Abstract

Background

To detect possible threats to quality and safety, multiple systems have been developed. One of them is retrospective chart review. A team of experts scrutinizes medical records, selected by trigger systems, to detect possible adverse events (AEs). The most important AEs and more hints for possible improvement of care appear in deceased patients. Using triggers in a sample of these patients might increase the performance and lower the burden of scrutinizing records without possible preventable AEs. The aim of this study was therefore to determine the performance of the trigger system in a sample of deceased patients and to calculate the specificity and the sensitivity of this trigger system for predicting AEs.

Methods

We performed a study in which the records of deceased patients were screened for triggers by a team of trained nurses. A sample of 100 medical records was randomly selected out of records which had been screened between 2012 and 2015 for the first time, prior to the study in 2016. For the determination of significant differences between the first and second screening, McNemar’s test of symmetry was used. Also, observed agreement, Cohen’s Kappa and prevalence-adjusted and-bias-adjusted-kappa (PABAK) statistics were calculated. This was done for the two trigger rounds on both any trigger present and for every trigger separately.

Results

The observed agreement for any given trigger was 75% with a Kappa and PABAK of 0.5. For the individual triggers, the observed agreement was on average 90%. The corresponding Kappa was on average 0.42 (range: − 0.03-0.78) and the average PABAK was 0.8 (range: 0.44–0.92). Two adverse events were found in cases without triggers previously. The recalculated specificity and sensitivity for the original population were 58 and 92% respectively.

Conclusions

For the reproducibility of triggers it seems that some perform better than others, but on average this is to our opinion suboptimal. The low specificity implies that many records are selected without AEs. This leads to a high false-positive rate making this labour-intensive record review process costly. Therefore, research for better and more expedient systems is required.
Literature
1.
go back to reference Kohn LT, Corrigan JM, Donaldson MS, editors. To Err is human: building a safer health system. Washington: National Academies Press (US); 2000. Kohn LT, Corrigan JM, Donaldson MS, editors. To Err is human: building a safer health system. Washington: National Academies Press (US); 2000.
2.
go back to reference Zegers M, et al. Adverse events and potentially preventable deaths in Dutch hospitals: results of a retrospective patient record review study. Qual Saf Health Care. 2009;18(4):297–302.CrossRef Zegers M, et al. Adverse events and potentially preventable deaths in Dutch hospitals: results of a retrospective patient record review study. Qual Saf Health Care. 2009;18(4):297–302.CrossRef
3.
go back to reference Langelaan, M., Monitor zorggerelateerde schade 2011/2012 - Dossieronderzoek in Nederlandse ziekenhuizen. 2013, EMGO+ Instituut/VUmc, NIVEL, Nederlands Instituut voor onderzoek van de gezondheidszorg. Langelaan, M., Monitor zorggerelateerde schade 2011/2012 - Dossieronderzoek in Nederlandse ziekenhuizen. 2013, EMGO+ Instituut/VUmc, NIVEL, Nederlands Instituut voor onderzoek van de gezondheidszorg.
4.
go back to reference Langelaan, M., Baines, R.J., Broekens, M.A. , Monitor Zorggerelateerde Schade 2008 - Dossieronderzoek in Nederlandse ziekenhuizen. 2008, EMGO+ Instituut/VUmc, NIVEL, Nederlands Instituut voor onderzoek van de gezondheidszorg. Langelaan, M., Baines, R.J., Broekens, M.A. , Monitor Zorggerelateerde Schade 2008 - Dossieronderzoek in Nederlandse ziekenhuizen. 2008, EMGO+ Instituut/VUmc, NIVEL, Nederlands Instituut voor onderzoek van de gezondheidszorg.
5.
go back to reference Landrigan CP, et al. Temporal trends in rates of patient harm resulting from medical care. N Engl J Med. 2010;363(22):2124–34.CrossRef Landrigan CP, et al. Temporal trends in rates of patient harm resulting from medical care. N Engl J Med. 2010;363(22):2124–34.CrossRef
6.
go back to reference Woloshynowych M, Neale G, Vincent C. Case record review of adverse events: a new approach. Qual Saf Health Care. 2003;12(6):411–5.CrossRef Woloshynowych M, Neale G, Vincent C. Case record review of adverse events: a new approach. Qual Saf Health Care. 2003;12(6):411–5.CrossRef
7.
go back to reference Resar RK, Rozich JD, Classen D. Methodology and rationale for the measurement of harm with trigger tools. Qual Saf Health Care. 2003;12(Suppl 2):ii39–45.PubMedPubMedCentral Resar RK, Rozich JD, Classen D. Methodology and rationale for the measurement of harm with trigger tools. Qual Saf Health Care. 2003;12(Suppl 2):ii39–45.PubMedPubMedCentral
8.
go back to reference Brennan TA, Leape LL. Adverse events, negligence in hospitalized patients: results from the Harvard medical practice study. Perspect Healthc Risk Manage. 1991;11(2):2–8.CrossRef Brennan TA, Leape LL. Adverse events, negligence in hospitalized patients: results from the Harvard medical practice study. Perspect Healthc Risk Manage. 1991;11(2):2–8.CrossRef
9.
go back to reference Classen DC, Lloyd RC, Provost L, Griffin FA, Resar R. Development and evaluation of the Institute for Healthcare Improvement Global Trigger Tool. J Patient Safety. 2008;4(3):169–77.CrossRef Classen DC, Lloyd RC, Provost L, Griffin FA, Resar R. Development and evaluation of the Institute for Healthcare Improvement Global Trigger Tool. J Patient Safety. 2008;4(3):169–77.CrossRef
10.
go back to reference Unbeck M, et al. Is detection of adverse events affected by record review methodology? An evaluation of the "Harvard medical practice study" method and the "global trigger tool". Patient Saf Surg. 2013;7(1):10.CrossRef Unbeck M, et al. Is detection of adverse events affected by record review methodology? An evaluation of the "Harvard medical practice study" method and the "global trigger tool". Patient Saf Surg. 2013;7(1):10.CrossRef
11.
go back to reference Hogan H, et al. Preventable deaths due to problems in care in English acute hospitals: a retrospective case record review study. BMJ Qual Saf. 2012;21(9):737–45.CrossRef Hogan H, et al. Preventable deaths due to problems in care in English acute hospitals: a retrospective case record review study. BMJ Qual Saf. 2012;21(9):737–45.CrossRef
12.
go back to reference Baines RJ, et al. Changes in adverse event rates in hospitals over time: a longitudinal retrospective patient record review study. BMJ Qual Saf. 2013;22(4):290–8.CrossRef Baines RJ, et al. Changes in adverse event rates in hospitals over time: a longitudinal retrospective patient record review study. BMJ Qual Saf. 2013;22(4):290–8.CrossRef
13.
go back to reference Baines R, et al. How effective are patient safety initiatives? A retrospective patient record review study of changes to patient safety over time. BMJ Qual Saf. 2015;24(9):561–71.CrossRef Baines R, et al. How effective are patient safety initiatives? A retrospective patient record review study of changes to patient safety over time. BMJ Qual Saf. 2015;24(9):561–71.CrossRef
15.
go back to reference Chen A, et al. Potentially preventable deaths in the Victorian audit of surgical mortality. ANZ J Surg. 2017;87(1–2):17–21.CrossRef Chen A, et al. Potentially preventable deaths in the Victorian audit of surgical mortality. ANZ J Surg. 2017;87(1–2):17–21.CrossRef
16.
go back to reference Schoeneberg C, et al. Preventable and potentially preventable deaths in severely injured elderly patients: a single-center retrospective data analysis of a German trauma center. World J Surg. 2014;38(12):3125–32.CrossRef Schoeneberg C, et al. Preventable and potentially preventable deaths in severely injured elderly patients: a single-center retrospective data analysis of a German trauma center. World J Surg. 2014;38(12):3125–32.CrossRef
17.
go back to reference Lau H, Litman KC. Saving lives by studying deaths: using standardized mortality reviews to improve inpatient safety. Jt Comm J Qual Patient Saf. 2011;37(9):400–8.CrossRef Lau H, Litman KC. Saving lives by studying deaths: using standardized mortality reviews to improve inpatient safety. Jt Comm J Qual Patient Saf. 2011;37(9):400–8.CrossRef
18.
go back to reference Zimmerman R, et al. Aiming for zero preventable deaths: using death review to improve care and reduce harm. Healthc Q. 2010;13 Spec No:81–7.CrossRef Zimmerman R, et al. Aiming for zero preventable deaths: using death review to improve care and reduce harm. Healthc Q. 2010;13 Spec No:81–7.CrossRef
19.
go back to reference Sharek PJ, Parry G, Goldmann D, Bones K, Hackbarth A, Resar R, et al. Performance characteristics of a methodology to quantify adverse events over time in hospitalized patients. Health Serv Res. 2011;46(2):654–78. Sharek PJ, Parry G, Goldmann D, Bones K, Hackbarth A, Resar R, et al. Performance characteristics of a methodology to quantify adverse events over time in hospitalized patients. Health Serv Res. 2011;46(2):654–78.
20.
go back to reference Langelaan M, de Bruijne MC, Baines RJ. Monitor zorggerelateerde schade 2011/2012 - Dossiersonderzoek in nederlandse ziekenhuizen; 2013. Langelaan M, de Bruijne MC, Baines RJ. Monitor zorggerelateerde schade 2011/2012 - Dossiersonderzoek in nederlandse ziekenhuizen; 2013.
21.
go back to reference de Bruine, M.C., Zegers, M., Hoonhout, L.H.F., Wagner, C.,, Onbedoelde schade in Nederlandse ziekenhuizen - Dossieronderzoek van ziekenhuisopnames in 2004 EMGO+ Instituut/VUmc, NIVEL, Nederlands Instituut voor onderzoek van de gezondheidszorg, 2004. de Bruine, M.C., Zegers, M., Hoonhout, L.H.F., Wagner, C.,, Onbedoelde schade in Nederlandse ziekenhuizen - Dossieronderzoek van ziekenhuisopnames in 2004 EMGO+ Instituut/VUmc, NIVEL, Nederlands Instituut voor onderzoek van de gezondheidszorg, 2004.
22.
go back to reference Brennan TA, et al. Incidence of adverse events and negligence in hospitalized patients. Results of the Harvard medical practice study I. N Engl J Med. 1991;324(6):370–6.CrossRef Brennan TA, et al. Incidence of adverse events and negligence in hospitalized patients. Results of the Harvard medical practice study I. N Engl J Med. 1991;324(6):370–6.CrossRef
23.
go back to reference Klein DO, et al. The ability of triggers to retrospectively predict potentially preventable adverse events in a sample of deceased patients. Prev Med Rep. 2017;8:250–5.CrossRef Klein DO, et al. The ability of triggers to retrospectively predict potentially preventable adverse events in a sample of deceased patients. Prev Med Rep. 2017;8:250–5.CrossRef
24.
go back to reference Byrt T, Bishop J, Carlin JB. Bias, prevalence and kappa. J Clin Epidemiol. 1993;46(5):423–9.CrossRef Byrt T, Bishop J, Carlin JB. Bias, prevalence and kappa. J Clin Epidemiol. 1993;46(5):423–9.CrossRef
25.
go back to reference Sari AB, et al. Sensitivity of routine system for reporting patient safety incidents in an NHS hospital: retrospective patient case note review. BMJ. 2007;334(7584):79.CrossRef Sari AB, et al. Sensitivity of routine system for reporting patient safety incidents in an NHS hospital: retrospective patient case note review. BMJ. 2007;334(7584):79.CrossRef
26.
go back to reference Soop M, et al. The incidence of adverse events in Swedish hospitals: a retrospective medical record review study. Int J Qual Health Care. 2009;21(4):285–91.CrossRef Soop M, et al. The incidence of adverse events in Swedish hospitals: a retrospective medical record review study. Int J Qual Health Care. 2009;21(4):285–91.CrossRef
27.
go back to reference Wilson RM, et al. Patient safety in developing countries: retrospective estimation of scale and nature of harm to patients in hospital. BMJ. 2012;344:e832.CrossRef Wilson RM, et al. Patient safety in developing countries: retrospective estimation of scale and nature of harm to patients in hospital. BMJ. 2012;344:e832.CrossRef
28.
go back to reference Landis JR, Koch GG. The measurement of observer agreement for categorical data. Biometrics. 1977;33(1):159–74.CrossRef Landis JR, Koch GG. The measurement of observer agreement for categorical data. Biometrics. 1977;33(1):159–74.CrossRef
29.
go back to reference Naessens JM, et al. Measuring hospital adverse events: assessing inter-rater reliability and trigger performance of the global trigger tool. Int J Qual Health Care. 2010;22(4):266–74.CrossRef Naessens JM, et al. Measuring hospital adverse events: assessing inter-rater reliability and trigger performance of the global trigger tool. Int J Qual Health Care. 2010;22(4):266–74.CrossRef
30.
go back to reference Ock M, et al. Assessing reliability of medical record reviews for the detection of hospital adverse events. J Prev Med Public Health. 2015;48(5):239–48.CrossRef Ock M, et al. Assessing reliability of medical record reviews for the detection of hospital adverse events. J Prev Med Public Health. 2015;48(5):239–48.CrossRef
31.
go back to reference Unbeck M, et al. Validation of triggers and development of a pediatric trigger tool to identify adverse events. BMC Health Serv Res. 2014;14:655.CrossRef Unbeck M, et al. Validation of triggers and development of a pediatric trigger tool to identify adverse events. BMC Health Serv Res. 2014;14:655.CrossRef
32.
go back to reference Classen DC, et al. 'Global trigger tool' shows that adverse events in hospitals may be ten times greater than previously measured. Health Aff (Millwood). 2011;30(4):581–9.CrossRef Classen DC, et al. 'Global trigger tool' shows that adverse events in hospitals may be ten times greater than previously measured. Health Aff (Millwood). 2011;30(4):581–9.CrossRef
33.
go back to reference Sharek PJ, et al. Performance characteristics of a methodology to quantify adverse events over time in hospitalized patients. Health Serv Res. 2011;46(2):654–78.CrossRef Sharek PJ, et al. Performance characteristics of a methodology to quantify adverse events over time in hospitalized patients. Health Serv Res. 2011;46(2):654–78.CrossRef
34.
go back to reference Landrigan CP, Parry GJ, Bones CB, Hackbarth AD, Goldmann DA, Sharek PJ. Temporal trends in rates of patient harm resulting from medical care. N Engl J Med. 2010;363(22):2124–34. Landrigan CP, Parry GJ, Bones CB, Hackbarth AD, Goldmann DA, Sharek PJ. Temporal trends in rates of patient harm resulting from medical care. N Engl J Med. 2010;363(22):2124–34.
35.
go back to reference Lander L, et al. A trigger tool fails to identify serious errors and adverse events in pediatric otolaryngology. Otolaryngol Head Neck Surg. 2010;143(4):480–6.CrossRef Lander L, et al. A trigger tool fails to identify serious errors and adverse events in pediatric otolaryngology. Otolaryngol Head Neck Surg. 2010;143(4):480–6.CrossRef
36.
go back to reference Matlow AG, et al. Description of the development and validation of the Canadian Paediatric trigger tool. BMJ Qual Saf. 2011;20(5):416–23.CrossRef Matlow AG, et al. Description of the development and validation of the Canadian Paediatric trigger tool. BMJ Qual Saf. 2011;20(5):416–23.CrossRef
37.
go back to reference Howard IL, et al. Development of a trigger tool to identify adverse events and harm in emergency medical services. Emerg Med J. 2017;34(6):391–7.CrossRef Howard IL, et al. Development of a trigger tool to identify adverse events and harm in emergency medical services. Emerg Med J. 2017;34(6):391–7.CrossRef
38.
go back to reference Neubert A, et al. Are computerised monitoring systems of value to improve pharmacovigilance in paediatric patients? Eur J Clin Pharmacol. 2006;62(11):959–65.CrossRef Neubert A, et al. Are computerised monitoring systems of value to improve pharmacovigilance in paediatric patients? Eur J Clin Pharmacol. 2006;62(11):959–65.CrossRef
39.
go back to reference Eggleton KS, Dovey SM. Using triggers in primary care patient records to flag increased adverse event risk and measure patient safety at clinic level. N Z Med J. 2014;127(1390):45–52.PubMed Eggleton KS, Dovey SM. Using triggers in primary care patient records to flag increased adverse event risk and measure patient safety at clinic level. N Z Med J. 2014;127(1390):45–52.PubMed
40.
go back to reference Hogan H, et al. Avoidability of hospital deaths and association with hospital-wide mortality ratios: retrospective case record review and regression analysis. BMJ. 2015;351:h3239.CrossRef Hogan H, et al. Avoidability of hospital deaths and association with hospital-wide mortality ratios: retrospective case record review and regression analysis. BMJ. 2015;351:h3239.CrossRef
41.
go back to reference Brennan, T.A., et al., Incidence of adverse events and negligence in hospitalized patients: Results of the Harvard medical practice study I. 1991. Qual Saf Health Care, 2004 13(2): 145–151; discussion 151-2. Brennan, T.A., et al., Incidence of adverse events and negligence in hospitalized patients: Results of the Harvard medical practice study I. 1991. Qual Saf Health Care, 2004 13(2): 145–151; discussion 151-2.
Metadata
Title
The Harvard medical practice study trigger system performance in deceased patients
Authors
Dorthe O. Klein
Roger J. M. W. Rennenberg
Richard P. Koopmans
Martin H. Prins
Publication date
01-12-2019
Publisher
BioMed Central
Published in
BMC Health Services Research / Issue 1/2019
Electronic ISSN: 1472-6963
DOI
https://doi.org/10.1186/s12913-018-3839-6

Other articles of this Issue 1/2019

BMC Health Services Research 1/2019 Go to the issue