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Published in: BMC Health Services Research 1/2018

Open Access 01-12-2018 | Research article

Choosing wisely? Quantifying the extent of three low value psychotropic prescribing practices in Australia

Authors: Jonathan Brett, Helga Zoega, Nicholas A. Buckley, Benjamin J. Daniels, Adam G. Elshaug, Sallie-Anne Pearson

Published in: BMC Health Services Research | Issue 1/2018

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Abstract

Background

The global Choosing Wisely campaign has identified the following psychotropic prescribing as low-value (harmful or wasteful): (1) benzodiazepine use in the elderly, (2) antipsychotic use in dementia and (3) prescribing two or more antipsychotics concurrently. We aimed to quantify the extent of these prescribing practices in the Australian population.

Methods

We applied indicators to dispensing claims of a 10% random sample of Australian Pharmaceutical Benefits Scheme beneficiaries to quantify annual rates of each low-value practice from 2013 to 2016. We also assessed patient factors and direct medicine costs (extrapolated to the entire Australian population) associated with each practice in 2016.

Results

We observed little change in the rates of the three practices between 2013 and 2016. In 2016, 15.3% of people aged ≥65 years were prescribed a benzodiazepine, 0.5% were prescribed antipsychotics in the context of dementia and 0.2% of people aged ≥18 years received two or more antipsychotics concurrently. The likelihood of elderly people receiving benzodiazepines or antipsychotics in the context of dementia increased with age and the likelihood of receiving all three practices increased with comorbidity burden. In 2016, direct medicine costs to the government of all three practices combined, extrapolated to national figures, were > $21 million AUD.

Conclusions

Our indicators suggest that the frequency of these three practices has not changed appreciably in recent years and that they incur significant costs. Worryingly, people with the greatest risk of harm from these prescribing practices are often the most likely to receive them.
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Literature
1.
go back to reference Scott I, Duckett S. In search of professional consensus in defining and reducing low-value care. Med J Aust. 2015;203(4):179–81.CrossRef Scott I, Duckett S. In search of professional consensus in defining and reducing low-value care. Med J Aust. 2015;203(4):179–81.CrossRef
2.
go back to reference Gliwa C, Pearson SD. Evidentiary rationales for the choosing wisely top 5 lists. J Am Med Assoc. 2014;311(14):1443–4.CrossRef Gliwa C, Pearson SD. Evidentiary rationales for the choosing wisely top 5 lists. J Am Med Assoc. 2014;311(14):1443–4.CrossRef
3.
go back to reference Brody H. Medicine’s ethical responsibility for health care reform—the top five list. N Engl J Med. 2010;362(4):283–5.CrossRef Brody H. Medicine’s ethical responsibility for health care reform—the top five list. N Engl J Med. 2010;362(4):283–5.CrossRef
4.
go back to reference Levinson W, Kallewaard M, Bhatia RS, Wolfson D, Shortt S, Kerr EA, Burgers J, Cucic C, Daniels M, Forde I. ‘Choosing wisely’: a growing international campaign. BMJ Qual Saf. 2015;24:167–74.CrossRef Levinson W, Kallewaard M, Bhatia RS, Wolfson D, Shortt S, Kerr EA, Burgers J, Cucic C, Daniels M, Forde I. ‘Choosing wisely’: a growing international campaign. BMJ Qual Saf. 2015;24:167–74.CrossRef
5.
go back to reference Schwartz AL, Landon BE, Elshaug AG, Chernew ME, McWilliams JM. Measuring low-value care in Medicare. JAMA Intern Med. 2014;174(7):1067–76.CrossRef Schwartz AL, Landon BE, Elshaug AG, Chernew ME, McWilliams JM. Measuring low-value care in Medicare. JAMA Intern Med. 2014;174(7):1067–76.CrossRef
6.
go back to reference Brett J, Elshaug AG, Bhatia RS, Chalmers K, Badgery-Parker T, Pearson S-A. A methodological protocol for selecting and quantifying low-value prescribing practices in routinely collected data: an Australian case study. Implement Sci. 2017;12(1):58.CrossRef Brett J, Elshaug AG, Bhatia RS, Chalmers K, Badgery-Parker T, Pearson S-A. A methodological protocol for selecting and quantifying low-value prescribing practices in routinely collected data: an Australian case study. Implement Sci. 2017;12(1):58.CrossRef
8.
go back to reference Mellish L, Karanges EA, Litchfield MJ, Schaffer AL, Blanch B, Daniels BJ, Segrave A, Pearson S-A. The Australian pharmaceutical benefits scheme data collection: a practical guide for researchers. BMC Res Notes. 2015;8(1):634.CrossRef Mellish L, Karanges EA, Litchfield MJ, Schaffer AL, Blanch B, Daniels BJ, Segrave A, Pearson S-A. The Australian pharmaceutical benefits scheme data collection: a practical guide for researchers. BMC Res Notes. 2015;8(1):634.CrossRef
10.
go back to reference Brett J, Daniels B, Karanges EA, Buckley NA, Schneider C, Nassir A, McLachlan AJ, Pearson SA. Psychotropic polypharmacy in Australia, 2006 to 2015: a descriptive cohort study. Br J Clin Pharmacol. 2017;83(11):2581–8.CrossRef Brett J, Daniels B, Karanges EA, Buckley NA, Schneider C, Nassir A, McLachlan AJ, Pearson SA. Psychotropic polypharmacy in Australia, 2006 to 2015: a descriptive cohort study. Br J Clin Pharmacol. 2017;83(11):2581–8.CrossRef
11.
go back to reference Leckman-Westin E, Kealey E, Gupta N, Chen Q, Gerhard T, Crystal S, Olfson M, Finnerty M. Validation of a claims-based antipsychotic polypharmacy measure. Pharmacoepidemiol Drug Saf. 2014;23(6):628–35.CrossRef Leckman-Westin E, Kealey E, Gupta N, Chen Q, Gerhard T, Crystal S, Olfson M, Finnerty M. Validation of a claims-based antipsychotic polypharmacy measure. Pharmacoepidemiol Drug Saf. 2014;23(6):628–35.CrossRef
13.
go back to reference Chalmers K, Pearson S-A, Elshaug AG. Quantifying low-value care: a patient-centric versus service-centric lens. BMJ Qual Saf. 2017;26:855–8.CrossRef Chalmers K, Pearson S-A, Elshaug AG. Quantifying low-value care: a patient-centric versus service-centric lens. BMJ Qual Saf. 2017;26:855–8.CrossRef
14.
go back to reference Vitry A, Wong SA, Roughead EE, Ramsay E, Barratt J. Validity of medication-based co-morbidity indices in the Australian elderly population. Aust N Z J Public Health. 2009;33(2):126–30.CrossRef Vitry A, Wong SA, Roughead EE, Ramsay E, Barratt J. Validity of medication-based co-morbidity indices in the Australian elderly population. Aust N Z J Public Health. 2009;33(2):126–30.CrossRef
15.
go back to reference Lader M. Benzodiazepines revisited—will we ever learn? Addiction. 2011;106(12):2086–109.CrossRef Lader M. Benzodiazepines revisited—will we ever learn? Addiction. 2011;106(12):2086–109.CrossRef
16.
go back to reference Gareri P, De Fazio P, De Fazio S, Marigliano N, Ibbadu GF, De Sarro G. Adverse effects of atypical antipsychotics in the elderly. Drugs Aging. 2006;23(12):937–56.CrossRef Gareri P, De Fazio P, De Fazio S, Marigliano N, Ibbadu GF, De Sarro G. Adverse effects of atypical antipsychotics in the elderly. Drugs Aging. 2006;23(12):937–56.CrossRef
17.
go back to reference Gallego JA, Nielsen J, De Hert M, Kane JM, Correll CU. Safety and tolerability of antipsychotic polypharmacy. Expert Opin Drug Saf. 2012;11(4):527–42.CrossRef Gallego JA, Nielsen J, De Hert M, Kane JM, Correll CU. Safety and tolerability of antipsychotic polypharmacy. Expert Opin Drug Saf. 2012;11(4):527–42.CrossRef
20.
go back to reference Maust DT, Kales HC, Wiechers IR, Blow FC, Olfson M. No end in sight: benzodiazepine use in older adults in the United States. J Am Geriatr Soc. 2016;64(12):2546–53.CrossRef Maust DT, Kales HC, Wiechers IR, Blow FC, Olfson M. No end in sight: benzodiazepine use in older adults in the United States. J Am Geriatr Soc. 2016;64(12):2546–53.CrossRef
21.
go back to reference Campanelli CM. American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in older adults: the American Geriatrics Society 2012 Beers Criteria Update Expert Panel. J Am Geriatr Soc. 2012;60(4):616.CrossRef Campanelli CM. American Geriatrics Society updated Beers Criteria for potentially inappropriate medication use in older adults: the American Geriatrics Society 2012 Beers Criteria Update Expert Panel. J Am Geriatr Soc. 2012;60(4):616.CrossRef
22.
go back to reference Gallagher P, Ryan C, Byrne S, Kennedy J, O’Mahony D. STOPP (Screening Tool of Older Person’s Prescriptions) and START (Screening Tool to Alert doctors to Right Treatment). Consensus validation. Int J Clin Pharmacol Ther. 2008;46(2):72–83.CrossRef Gallagher P, Ryan C, Byrne S, Kennedy J, O’Mahony D. STOPP (Screening Tool of Older Person’s Prescriptions) and START (Screening Tool to Alert doctors to Right Treatment). Consensus validation. Int J Clin Pharmacol Ther. 2008;46(2):72–83.CrossRef
23.
go back to reference Colla CH, Morden NE, Sequist TD, Schpero WL, Rosenthal MB. Choosing wisely: prevalence and correlates of low-value health care services in the United States. J Gen Intern Med. 2015;30(2):221–8.CrossRef Colla CH, Morden NE, Sequist TD, Schpero WL, Rosenthal MB. Choosing wisely: prevalence and correlates of low-value health care services in the United States. J Gen Intern Med. 2015;30(2):221–8.CrossRef
24.
go back to reference Child A, Clarke A, Fox C, Maidment I. A pharmacy led program to review anti-psychotic prescribing for people with dementia. BMC Psychiatry. 2012;12(1):155.CrossRef Child A, Clarke A, Fox C, Maidment I. A pharmacy led program to review anti-psychotic prescribing for people with dementia. BMC Psychiatry. 2012;12(1):155.CrossRef
25.
go back to reference Routledge PA, O’Mahony M, Woodhouse K. Adverse drug reactions in elderly patients. Br J Clin Pharmacol. 2004;57(2):121–6.CrossRef Routledge PA, O’Mahony M, Woodhouse K. Adverse drug reactions in elderly patients. Br J Clin Pharmacol. 2004;57(2):121–6.CrossRef
26.
go back to reference Cabana MD, Rand CS, Powe NR, Wu AW, Wilson MH, Abboud P-AC, Rubin HR. Why don't physicians follow clinical practice guidelines?: a framework for improvement. J Am Med Assoc. 1999;282(15):1458–65.CrossRef Cabana MD, Rand CS, Powe NR, Wu AW, Wilson MH, Abboud P-AC, Rubin HR. Why don't physicians follow clinical practice guidelines?: a framework for improvement. J Am Med Assoc. 1999;282(15):1458–65.CrossRef
27.
go back to reference Hilmer SN, Gnjidic D. Rethinking psychotropics in nursing homes. Med J Aust. 2013;198(2):77.CrossRef Hilmer SN, Gnjidic D. Rethinking psychotropics in nursing homes. Med J Aust. 2013;198(2):77.CrossRef
28.
go back to reference Maidment ID, Shaw RL, Killick K, Damery S, Hilton A, Wilcock J, et al. Improving the management of behaviour that challenges associated with dementia in care homes: protocol for pharmacy–health psychology intervention feasibility study. BMJ Open. 2016;6(3):e010279.CrossRef Maidment ID, Shaw RL, Killick K, Damery S, Hilton A, Wilcock J, et al. Improving the management of behaviour that challenges associated with dementia in care homes: protocol for pharmacy–health psychology intervention feasibility study. BMJ Open. 2016;6(3):e010279.CrossRef
29.
go back to reference Ailabouni N, Mangin D, Nishtala PS. Deprescribing anticholinergic and sedative medicines: protocol for a feasibility trial (DEFEAT-polypharmacy) in residential aged care facilities. BMJ Open. 2017;7(4):e013800.CrossRef Ailabouni N, Mangin D, Nishtala PS. Deprescribing anticholinergic and sedative medicines: protocol for a feasibility trial (DEFEAT-polypharmacy) in residential aged care facilities. BMJ Open. 2017;7(4):e013800.CrossRef
30.
go back to reference Hollingworth SA, Siskind DJ. Anxiolytic, hypnotic and sedative medication use in Australia. Pharmacoepidemiol Drug Saf. 2010;19(3):280–8.CrossRef Hollingworth SA, Siskind DJ. Anxiolytic, hypnotic and sedative medication use in Australia. Pharmacoepidemiol Drug Saf. 2010;19(3):280–8.CrossRef
31.
go back to reference Lu CY, Barratt J, Vitry A, Roughead E. Charlson and Rx-risk comorbidity indices were predictive of mortality in the Australian health care setting. J Clin Epidemiol. 2011;64(2):223–8.CrossRef Lu CY, Barratt J, Vitry A, Roughead E. Charlson and Rx-risk comorbidity indices were predictive of mortality in the Australian health care setting. J Clin Epidemiol. 2011;64(2):223–8.CrossRef
32.
go back to reference Goeman D, Harvey K, Lee CY, Petrie N, Beanland C, Culhane C, Koch S. How prolific is psychotropic medicines use in people with dementia in Australia within the community setting? A retrospective analysis. Drugs Real World Outcomes. 2015;2(3):289–98.CrossRef Goeman D, Harvey K, Lee CY, Petrie N, Beanland C, Culhane C, Koch S. How prolific is psychotropic medicines use in people with dementia in Australia within the community setting? A retrospective analysis. Drugs Real World Outcomes. 2015;2(3):289–98.CrossRef
33.
go back to reference Rattinger GB, Burcu M, Dutcher SK, Chhabra PT, Rosenberg PB, Simoni-Wastila L, Franey CS, Walker LD, Zuckerman IH. Pharmacotherapeutic management of dementia across settings of care. J Am Geriatr Soc. 2013;61(5):723–33.CrossRef Rattinger GB, Burcu M, Dutcher SK, Chhabra PT, Rosenberg PB, Simoni-Wastila L, Franey CS, Walker LD, Zuckerman IH. Pharmacotherapeutic management of dementia across settings of care. J Am Geriatr Soc. 2013;61(5):723–33.CrossRef
34.
go back to reference Watts JJ, Abimanyi-Ochom J, Sanders KM. Osteoporosis costing all Australian: a new burden of disease analysis-2012 to 2022; 2013. Watts JJ, Abimanyi-Ochom J, Sanders KM. Osteoporosis costing all Australian: a new burden of disease analysis-2012 to 2022; 2013.
Metadata
Title
Choosing wisely? Quantifying the extent of three low value psychotropic prescribing practices in Australia
Authors
Jonathan Brett
Helga Zoega
Nicholas A. Buckley
Benjamin J. Daniels
Adam G. Elshaug
Sallie-Anne Pearson
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Health Services Research / Issue 1/2018
Electronic ISSN: 1472-6963
DOI
https://doi.org/10.1186/s12913-018-3811-5

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