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Published in: BMC Health Services Research 1/2017

Open Access 01-12-2017 | Research article

Identification of outliers and positive deviants for healthcare improvement: looking for high performers in hypoglycemia safety in patients with diabetes

Authors: Brigid Wilson, Chin-Lin Tseng, Orysya Soroka, Leonard M. Pogach, David C. Aron

Published in: BMC Health Services Research | Issue 1/2017

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Abstract

Background

The study objectives were to determine: (1) how statistical outliers exhibiting low rates of diabetes overtreatment performed on a reciprocal measure – rates of diabetes undertreatment; and (2) the impact of different criteria on high performing outlier status.

Methods

The design was serial cross-sectional, using yearly Veterans Health Administration (VHA) administrative data (2009–2013). Our primary outcome measure was facility rate of HbA1c overtreatment of diabetes in patients at risk for hypoglycemia. Outlier status was assessed by using two approaches: calculating a facility outlier value within year, comparator group, and A1c threshold while incorporating at risk population sizes; and examining standardized model residuals across year and A1c threshold. Facilities with outlier values in the lowest decile for all years of data using more than one threshold and comparator or with time-averaged model residuals in the lowest decile for all A1c thresholds were considered high performing outliers.

Results

Using outlier values, three of the 27 high performers from 2009 were also identified in 2010–2013 and considered outliers. There was only modest overlap between facilities identified as top performers based on three thresholds: A1c < 6%, A1c < 6.5%, and A1c < 7%. There was little effect of facility complexity or regional Veterans Integrated Service Networks (VISNs) on outlier identification. Consistent high performing facilities for overtreatment had higher rates of undertreatment (A1c > 9%) than VA average in the population of patients at high risk for hypoglycemia.

Conclusions

Statistical identification of positive deviants for diabetes overtreatment was dependent upon the specific measures and approaches used. Moreover, because two facilities may arrive at the same results via very different pathways, it is important to consider that a “best” practice may actually reflect a separate “worst” practice.
Literature
1.
go back to reference Bretschneider S, Marc-Aurele F Jr, Wu J. “best practices” research: a methodological guide for the perplexed. J Public Adm Res Theory. 2005;15(2):307–23.CrossRef Bretschneider S, Marc-Aurele F Jr, Wu J. “best practices” research: a methodological guide for the perplexed. J Public Adm Res Theory. 2005;15(2):307–23.CrossRef
2.
go back to reference Guzman G, Fitzgerald JA, Fulop L, Hayes K, Poropat A, Avery M, et al. How best practices are copied, transferred, or translated between health care facilities: a conceptual framework. Health Care Manage Rev. 2015;40(3):193–202.CrossRefPubMed Guzman G, Fitzgerald JA, Fulop L, Hayes K, Poropat A, Avery M, et al. How best practices are copied, transferred, or translated between health care facilities: a conceptual framework. Health Care Manage Rev. 2015;40(3):193–202.CrossRefPubMed
3.
go back to reference Maggs-Rapport F. ‘Best research practice’: in pursuit of methodological rigour. J Adv Nurs. 2001;35(3):373–83.CrossRefPubMed Maggs-Rapport F. ‘Best research practice’: in pursuit of methodological rigour. J Adv Nurs. 2001;35(3):373–83.CrossRefPubMed
4.
go back to reference Mold J, Gregory M. Best practices research. Fam Med. 2003;35(3):131–4.PubMed Mold J, Gregory M. Best practices research. Fam Med. 2003;35(3):131–4.PubMed
5.
go back to reference Gaspar J, Catumbela E, Marques B, Freitas A. A systematic review of outliers detection techniques in medical data: preliminary study. Rome: HEALTHINF; 2011. p. 2011. Gaspar J, Catumbela E, Marques B, Freitas A. A systematic review of outliers detection techniques in medical data: preliminary study. Rome: HEALTHINF; 2011. p. 2011.
6.
go back to reference Hodge V, Austin J. A survey of outlier detection methodologies. Artif Intell Rev. 2004;22(2):85–126.CrossRef Hodge V, Austin J. A survey of outlier detection methodologies. Artif Intell Rev. 2004;22(2):85–126.CrossRef
8.
go back to reference Baxter R, Kellar I, Taylor N, Lawton R. How is the positive deviance approach applied within healthcare organizations? A systematic review of methods used. BMC Health Serv Res. 2014;14(Suppl 2):7.CrossRef Baxter R, Kellar I, Taylor N, Lawton R. How is the positive deviance approach applied within healthcare organizations? A systematic review of methods used. BMC Health Serv Res. 2014;14(Suppl 2):7.CrossRef
9.
go back to reference Bradley EH, Curry LA, Ramanadhan S, Rowe L, Nembhard IM, Krumholz HM. Research in action: using positive deviance to improve quality of health care. Implement Sci. 2009;4:25.CrossRefPubMedPubMedCentral Bradley EH, Curry LA, Ramanadhan S, Rowe L, Nembhard IM, Krumholz HM. Research in action: using positive deviance to improve quality of health care. Implement Sci. 2009;4:25.CrossRefPubMedPubMedCentral
10.
go back to reference Krumholz HM, Curry LA, Bradley EH. Survival after acute myocardial infarction (SAMI) study: the design and implementation of a positive deviance study. Am Heart J. 2011;162(6):981–7.CrossRefPubMedPubMedCentral Krumholz HM, Curry LA, Bradley EH. Survival after acute myocardial infarction (SAMI) study: the design and implementation of a positive deviance study. Am Heart J. 2011;162(6):981–7.CrossRefPubMedPubMedCentral
11.
go back to reference Lawton J, Fox A, Fox C, Kinmonth A. Participating in the United Kingdom prospective diabetes study (UKPDS): a qualitative study of patients’ experiences. Br J Gen Pract. 2003;52(490):394–8. Lawton J, Fox A, Fox C, Kinmonth A. Participating in the United Kingdom prospective diabetes study (UKPDS): a qualitative study of patients’ experiences. Br J Gen Pract. 2003;52(490):394–8.
12.
go back to reference Luft HS. Data and methods to facilitate delivery system reform: harnessing collective intelligence to learn from positive deviance. Health Serv Res. 2010;45(5 Pt 2):1570–80.CrossRefPubMedPubMedCentral Luft HS. Data and methods to facilitate delivery system reform: harnessing collective intelligence to learn from positive deviance. Health Serv Res. 2010;45(5 Pt 2):1570–80.CrossRefPubMedPubMedCentral
13.
go back to reference Setiawan M, Sadiq S. A methodology for improving business process performance through positive deviance. Int J Inf Sys Model Des. 2013;4(2):1–22.CrossRef Setiawan M, Sadiq S. A methodology for improving business process performance through positive deviance. Int J Inf Sys Model Des. 2013;4(2):1–22.CrossRef
14.
go back to reference Singhal A, Greiner K. Using the positive deviance approach to reduce hospital-acquired infections at the veterans administration healthcare system in Pittsburgh. In: Suchman A, Sluyter D, Williamson P, editors. Leading change in healthcare: transforming organizations using complexity, positive psychology, and relationship-centered care. Radcliffe Publishing: New York; 2011. p. 177–209. Singhal A, Greiner K. Using the positive deviance approach to reduce hospital-acquired infections at the veterans administration healthcare system in Pittsburgh. In: Suchman A, Sluyter D, Williamson P, editors. Leading change in healthcare: transforming organizations using complexity, positive psychology, and relationship-centered care. Radcliffe Publishing: New York; 2011. p. 177–209.
15.
go back to reference Duckworth W, Abraira C, Moritz T, Reda D, Emanuele N. Al e. Glucose control and vascular complications in veterans with type 2 diabetes. N Engl J Med. 2009;360(2):129–39.CrossRefPubMed Duckworth W, Abraira C, Moritz T, Reda D, Emanuele N. Al e. Glucose control and vascular complications in veterans with type 2 diabetes. N Engl J Med. 2009;360(2):129–39.CrossRefPubMed
16.
go back to reference Miller ME, Bonds DE, Gerstein HC, Seaquist ER, Bergenstal RM, Calles-Escandon J, et al. The effects of baseline characteristics, glycaemia treatment approach, and glycated haemoglobin concentration on the risk of severe hypoglycaemia: post hoc epidemiological analysis of the ACCORD study. BMJ. 2010;340:b5444. published onlineCrossRefPubMedPubMedCentral Miller ME, Bonds DE, Gerstein HC, Seaquist ER, Bergenstal RM, Calles-Escandon J, et al. The effects of baseline characteristics, glycaemia treatment approach, and glycated haemoglobin concentration on the risk of severe hypoglycaemia: post hoc epidemiological analysis of the ACCORD study. BMJ. 2010;340:b5444. published onlineCrossRefPubMedPubMedCentral
17.
18.
go back to reference Aron DC. Quality indicators and performance measures in diabetes care. Curr Diab Rep. 2014;14(3):472.CrossRefPubMed Aron DC. Quality indicators and performance measures in diabetes care. Curr Diab Rep. 2014;14(3):472.CrossRefPubMed
19.
go back to reference Pogach L, Aron D. Quality of diabetes care (current levels, distribution, and trends) and challenges in measuring quality of care. In: Moran S, Gregg E, Williams D, Cowie C, Narayan K, eds. Diabetes and public health: from data to policy: Oxford University Press; 2010:373. Pogach L, Aron D. Quality of diabetes care (current levels, distribution, and trends) and challenges in measuring quality of care. In: Moran S, Gregg E, Williams D, Cowie C, Narayan K, eds. Diabetes and public health: from data to policy: Oxford University Press; 2010:373.
20.
go back to reference Lipska KJ, Ross JS, Miao Y, Shah ND, Lee SJ, Steinman MA. Potential overtreatment of diabetes mellitus in older adults with tight glycemic control. JAMA Intern Med. 2015;175(3):356–62.CrossRefPubMedPubMedCentral Lipska KJ, Ross JS, Miao Y, Shah ND, Lee SJ, Steinman MA. Potential overtreatment of diabetes mellitus in older adults with tight glycemic control. JAMA Intern Med. 2015;175(3):356–62.CrossRefPubMedPubMedCentral
21.
go back to reference Lipska KJ, Ross JS, Wang Y, Inzucchi SE, Minges K, Karter AJ, et al. National trends in US hospital admissions for hyperglycemia and hypoglycemia among Medicare beneficiaries, 1999 to 2011. JAMA Intern Med. 2014;174(7):1116–24.CrossRefPubMedPubMedCentral Lipska KJ, Ross JS, Wang Y, Inzucchi SE, Minges K, Karter AJ, et al. National trends in US hospital admissions for hyperglycemia and hypoglycemia among Medicare beneficiaries, 1999 to 2011. JAMA Intern Med. 2014;174(7):1116–24.CrossRefPubMedPubMedCentral
22.
go back to reference Tseng CL, Soroka O, Maney M, Aron DC, Pogach LM. Assessing potential glycemic overtreatment in persons at hypoglycemic risk. JAMA Intern Med. 2014;174(2):259–68.CrossRefPubMed Tseng CL, Soroka O, Maney M, Aron DC, Pogach LM. Assessing potential glycemic overtreatment in persons at hypoglycemic risk. JAMA Intern Med. 2014;174(2):259–68.CrossRefPubMed
23.
go back to reference Inzucchi SE, Siegel MD. Glucose control in the ICU — how tight is too tight? N Engl J Med. 2009;360(13):1346–9.CrossRefPubMed Inzucchi SE, Siegel MD. Glucose control in the ICU — how tight is too tight? N Engl J Med. 2009;360(13):1346–9.CrossRefPubMed
24.
go back to reference Ismail-Beigi F, Moghissi ES, Tiktin M, Hirsch IB, Inzucchi SE, Genuth S. Individualizing Glycemic targets in type 2 diabetes mellitus: implications of recent clinical trials. Ann Intern Med. 2011;154:554–9.CrossRefPubMed Ismail-Beigi F, Moghissi ES, Tiktin M, Hirsch IB, Inzucchi SE, Genuth S. Individualizing Glycemic targets in type 2 diabetes mellitus: implications of recent clinical trials. Ann Intern Med. 2011;154:554–9.CrossRefPubMed
25.
go back to reference Montori V, Fernandez-Balsells M. Glycemic control in type 2 diabetes: time for an evidence-based about-face? Ann Intern Med. 2009;150:803–8.CrossRefPubMed Montori V, Fernandez-Balsells M. Glycemic control in type 2 diabetes: time for an evidence-based about-face? Ann Intern Med. 2009;150:803–8.CrossRefPubMed
26.
go back to reference Pogach L, Aron D. Balancing hypoglycemia and glycemic control: a public health approach for insulin safety. JAMA. 2010;303(20):2076–7.CrossRefPubMed Pogach L, Aron D. Balancing hypoglycemia and glycemic control: a public health approach for insulin safety. JAMA. 2010;303(20):2076–7.CrossRefPubMed
27.
go back to reference Pogach LM, Tiwari A, Maney M, Rajan M, Miller DR, Aron D. Should mitigating comorbidities be considered in assessing healthcare plan performance in achieving optimal glycemic control? Am J Manag Care. 2007;13(3):133–40.PubMed Pogach LM, Tiwari A, Maney M, Rajan M, Miller DR, Aron D. Should mitigating comorbidities be considered in assessing healthcare plan performance in achieving optimal glycemic control? Am J Manag Care. 2007;13(3):133–40.PubMed
30.
go back to reference Lawton R, Taylor N, Clay-Williams R, Braithwaite J. Positive deviance: a different approach to achieving patient safety. BMJ Qual Saf. 2014;23(11):880–3.CrossRefPubMedPubMedCentral Lawton R, Taylor N, Clay-Williams R, Braithwaite J. Positive deviance: a different approach to achieving patient safety. BMJ Qual Saf. 2014;23(11):880–3.CrossRefPubMedPubMedCentral
31.
go back to reference Pogach L, Rajan M, Aron D. Aligning performance measurement with clinical epidemiology: comparison of weighted performance measurement and dichotomous threshold for glycemic control in the veterans health administration. Diabetes Care. 2006;29:241–6.CrossRefPubMed Pogach L, Rajan M, Aron D. Aligning performance measurement with clinical epidemiology: comparison of weighted performance measurement and dichotomous threshold for glycemic control in the veterans health administration. Diabetes Care. 2006;29:241–6.CrossRefPubMed
32.
go back to reference Aron DC. No “black swan”: unintended but not unanticipated consequences of diabetes performance measurement. Jt Comm J Qual Patient Saf. 2013;39(3):106–8.CrossRefPubMed Aron DC. No “black swan”: unintended but not unanticipated consequences of diabetes performance measurement. Jt Comm J Qual Patient Saf. 2013;39(3):106–8.CrossRefPubMed
34.
go back to reference Tabachnick BG, Fidell LS. Using multivariate statistics. 3rd ed. New York: Harper Collins; 1996. Tabachnick BG, Fidell LS. Using multivariate statistics. 3rd ed. New York: Harper Collins; 1996.
35.
go back to reference Bilimoria KY, Shen WT, Elaraj D, Bentrem DJ, Winchester DJ, Kebebew E, et al. Adrenocortical carcinoma in the United States: treatment utilization and prognostic factors. Cancer. 2008;113(11):3130–6.CrossRefPubMed Bilimoria KY, Shen WT, Elaraj D, Bentrem DJ, Winchester DJ, Kebebew E, et al. Adrenocortical carcinoma in the United States: treatment utilization and prognostic factors. Cancer. 2008;113(11):3130–6.CrossRefPubMed
36.
go back to reference Mull HJ, Chen Q, O’Brien WJ, Shwartz M, Borzecki AM, Hanchate A, et al. Comparing 2 methods of assessing 30-day readmissions: what is the impact on hospital profiling in the veterans health administration? Med Care. 2013;51(7):589–96.CrossRefPubMedPubMedCentral Mull HJ, Chen Q, O’Brien WJ, Shwartz M, Borzecki AM, Hanchate A, et al. Comparing 2 methods of assessing 30-day readmissions: what is the impact on hospital profiling in the veterans health administration? Med Care. 2013;51(7):589–96.CrossRefPubMedPubMedCentral
37.
go back to reference Rothberg MB, Morsi E, Benjamin EM, Pekow PS, Lindenauer PK. Choosing the best hospital: the limitations of public quality reporting. Health Aff (Millwood). 2008;27(6):1680–7.CrossRef Rothberg MB, Morsi E, Benjamin EM, Pekow PS, Lindenauer PK. Choosing the best hospital: the limitations of public quality reporting. Health Aff (Millwood). 2008;27(6):1680–7.CrossRef
38.
go back to reference Paddock SM, Adams JL, dlG H. Better-than-average and worse-than-average hospitals may not significantly differ from average hospitals: an analysis of Medicare hospital compare ratings. BMJ Qual Saf. 2015;24(2):128–34.CrossRefPubMed Paddock SM, Adams JL, dlG H. Better-than-average and worse-than-average hospitals may not significantly differ from average hospitals: an analysis of Medicare hospital compare ratings. BMJ Qual Saf. 2015;24(2):128–34.CrossRefPubMed
39.
go back to reference Jorgensen TS, Osler M, Angquist LH, Zimmermann E, Christensen GT, Sorensen TI. The U-shaped association of body mass index with mortality: influence of the traits height, intelligence, and education. Obesity (Silver Spring). 2016;24(10):2240–7.CrossRef Jorgensen TS, Osler M, Angquist LH, Zimmermann E, Christensen GT, Sorensen TI. The U-shaped association of body mass index with mortality: influence of the traits height, intelligence, and education. Obesity (Silver Spring). 2016;24(10):2240–7.CrossRef
40.
go back to reference Gomadam P, Shah A, Qureshi W, Yeboah PN, Freedman BI, Bowden D, Soliman EZ, Yeboah J. Blood pressure indices and cardiovascular disease mortality in persons with or without diabetes mellitus. J Hypertens. 2017. doi:10.1097/HJH.0000000000001509. [Epub ahead of print]. Gomadam P, Shah A, Qureshi W, Yeboah PN, Freedman BI, Bowden D, Soliman EZ, Yeboah J. Blood pressure indices and cardiovascular disease mortality in persons with or without diabetes mellitus. J Hypertens. 2017. doi:10.​1097/​HJH.​0000000000001509​. [Epub ahead of print].
42.
go back to reference Pascale R, Sternin J, Sternin M. The power of positive deviance: how unlikely innovators solve the World’s toughest problems. Boston: Harvard Business Press; 2010. Pascale R, Sternin J, Sternin M. The power of positive deviance: how unlikely innovators solve the World’s toughest problems. Boston: Harvard Business Press; 2010.
43.
go back to reference Sternin J. Practice positive deviance for extraordinary social and organizational change. The Change Champion’s Field Guide: Strategies and Tools for Leading Change in Your Organization. Hoboken: John Wiley & Sons; 2013. pp. 20–37. Sternin J. Practice positive deviance for extraordinary social and organizational change. The Change Champion’s Field Guide: Strategies and Tools for Leading Change in Your Organization. Hoboken: John Wiley & Sons; 2013. pp. 20–37.
44.
go back to reference Zeitlin M, Ghassemi H, Mansour M. Positive deviance in child nutrition - with emphasis on psychosocial and Behavioural aspects and implications for development. New York: United Nations University Press; 1991. Zeitlin M, Ghassemi H, Mansour M. Positive deviance in child nutrition - with emphasis on psychosocial and Behavioural aspects and implications for development. New York: United Nations University Press; 1991.
45.
go back to reference Bradley EH, Herrin J, Wang Y, Barton BA, Webster TR, Mattera JA, et al. Strategies for reducing the door-to-balloon time in acute myocardial infarction. N Engl J Med. 2006;355(22):2308–20.CrossRefPubMed Bradley EH, Herrin J, Wang Y, Barton BA, Webster TR, Mattera JA, et al. Strategies for reducing the door-to-balloon time in acute myocardial infarction. N Engl J Med. 2006;355(22):2308–20.CrossRefPubMed
46.
go back to reference Ramalingam B, Laric M, Primrose J. From best practice to best fit: understanding and navigating wicked problems in international development. London: Overseas Development Institute; 2014. p. 1–44. Ramalingam B, Laric M, Primrose J. From best practice to best fit: understanding and navigating wicked problems in international development. London: Overseas Development Institute; 2014. p. 1–44.
47.
go back to reference Urbach DR, Govindarajan A, Saskin R, Wilton AS, Baxter NN. Introduction of surgical safety checklists in Ontario, Canada. N Engl J Med. 2014;370(11):1029–38.CrossRefPubMed Urbach DR, Govindarajan A, Saskin R, Wilton AS, Baxter NN. Introduction of surgical safety checklists in Ontario, Canada. N Engl J Med. 2014;370(11):1029–38.CrossRefPubMed
Metadata
Title
Identification of outliers and positive deviants for healthcare improvement: looking for high performers in hypoglycemia safety in patients with diabetes
Authors
Brigid Wilson
Chin-Lin Tseng
Orysya Soroka
Leonard M. Pogach
David C. Aron
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Health Services Research / Issue 1/2017
Electronic ISSN: 1472-6963
DOI
https://doi.org/10.1186/s12913-017-2692-3

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