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BMC Health Services Research
Published in: BMC Health Services Research 1/2017

Open Access 01-12-2017 | Research article

Cost-effectiveness of lung cancer screening and treatment methods: a systematic review of systematic reviews

Authors: Farbod Ebadifard Azar, Saber Azami-Aghdash, Fatemeh Pournaghi-Azar, Alireza Mazdaki, Aziz Rezapour, Parvin Ebrahimi, Negar Yousefzadeh

Published in: BMC Health Services Research | Issue 1/2017

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Abstract

Background

Due to extensive literature in the field of lung cancer and their heterogeneous results, the aim of this study was to systematically review of systematic reviews studies which reviewed the cost-effectiveness of various lung cancer screening and treatment methods.

Methods

In this systematic review of systematic reviews study, required data were collected searching the following key words which selected from Mesh: “lung cancer”, “lung oncology”, “lung Carcinoma”, “lung neoplasm”, “lung tumors”, “cost- effectiveness”, “systematic review” and “Meta-analysis”. The following databases were searched: PubMed, Cochrane Library electronic databases, Google Scholar, and Scopus. Two reviewers (RA and A-AS) evaluated the articles according to the checklist of “assessment of multiple systematic reviews” (AMSTAR) tool.

Results

Overall, information of 110 papers was discussed in eight systematic reviews. Authors focused on cost-effectiveness of lung cancer treatments in five systematic reviews. Targeted therapy options (bevacizumab, Erlotinib and Crizotinib) show an acceptable cost-effectiveness. Results of three studies failed to show cost-effectiveness of screening methods. None of the studies had used the meta-analysis method. The Quality of Health Economic Studies (QHES) tool and Drummond checklist were mostly used in assessing the quality of articles. Most perspective was related to the Payer (64 times) and the lowest was related to Social (11times). Most cases referred to Incremental analysis (82%) and also the lowest point of referral was related to Discounting (in 49% of the cases). The average quality score of included studies was calculated 9.2% from 11.

Conclusions

Targeted therapy can be an option for the treatment of lung cancer. Evaluation of the cost-effectiveness of computerized tomographic colonography (CTC) in lung cancer screening is recommended. The perspective of the community should be more taken into consideration in studies of cost-effectiveness. Paying more attention to the topic of Discounting will be necessary in the studies.
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Metadata
Title
Cost-effectiveness of lung cancer screening and treatment methods: a systematic review of systematic reviews
Authors
Farbod Ebadifard Azar
Saber Azami-Aghdash
Fatemeh Pournaghi-Azar
Alireza Mazdaki
Aziz Rezapour
Parvin Ebrahimi
Negar Yousefzadeh
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Health Services Research / Issue 1/2017
Electronic ISSN: 1472-6963
DOI
https://doi.org/10.1186/s12913-017-2374-1

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