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Published in: BMC Complementary Medicine and Therapies 1/2018

Open Access 01-12-2018 | Research article

Beneficial effect of compound essential oil inhalation on central fatigue

Authors: Chenxia Han, Feng Li, Simin Tian, Yan Liu, Huai Xiao, Xiumei Wu, Weiyue Zhang, Wei Zhang, Meng Mao

Published in: BMC Complementary Medicine and Therapies | Issue 1/2018

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Abstract

Backgrounds

Although the physical and mental enhancement effect of essential oils have been proved, the beneficial effect of essential oil in central fatigue remains unclear. In this study, we extracted essential oils from nine aromatic plants to make a compound essential oil, and detected the therapeutic effect of central fatigue by daily aerial diffusion.

Methods

Thirty-three rats were randomly and equally divided into control group, chronic sleep deprivation group, and compound essential oil inhalation group. Central fatigue was generated by chronic sleep deprivation.

Results

After 21-day various interferences, it is found that the sleep deprivation rats showed an evident decrease in physical endurance, negative emotion, and cognitive dysfunction compared with the control group, and the group that treated with the compound essential oil behaved significantly better than central fatigue group.

Conclusion

We concluded that this formula of essential oils could alleviate central fatigue on rats, and our study provides a new direction of application of aromatic therapy, which could be expanded to insomnia, depression and other healthy issue in the further research.
Literature
1.
go back to reference Smith A. The Olfactory Process and its Effect on Human Behavior. Biology 202 Second Web Reports On Serendip. 1999. Smith A. The Olfactory Process and its Effect on Human Behavior. Biology 202 Second Web Reports On Serendip. 1999.
2.
go back to reference Gattefosse RM. Gattefosse's Aromatherapy. In: Essex. England: CW Daniel; 1993. Gattefosse RM. Gattefosse's Aromatherapy. In: Essex. England: CW Daniel; 1993.
3.
go back to reference Yim VW, Ng AK, Tsang HW, Leung AY. A review on the effects of aromatherapy for patients with depressive symptoms. J Altern Complement Med. 2009;15(2):187–95.CrossRef Yim VW, Ng AK, Tsang HW, Leung AY. A review on the effects of aromatherapy for patients with depressive symptoms. J Altern Complement Med. 2009;15(2):187–95.CrossRef
4.
go back to reference Chnaubelt K. Medical Aromatherapy: Healing With Essential Oils. Berkeley: Frog Ltd; 1999. Chnaubelt K. Medical Aromatherapy: Healing With Essential Oils. Berkeley: Frog Ltd; 1999.
5.
go back to reference Shiina Y, Funabashi N, Lee K, Toyoda T, Sekine T, Honjo S, Hasegawa R, Kawata T, Wakatsuki Y, Hayashi S, Murakami S, Koike K, Daimon M, Komuro I. Relaxation effects of lavender aromatherapy improve coronary flow velocity reserve in healthy men evaluated by transthoracic Doppler echocardiography. Int J Cardiol. 2008;129(2):193–7.CrossRef Shiina Y, Funabashi N, Lee K, Toyoda T, Sekine T, Honjo S, Hasegawa R, Kawata T, Wakatsuki Y, Hayashi S, Murakami S, Koike K, Daimon M, Komuro I. Relaxation effects of lavender aromatherapy improve coronary flow velocity reserve in healthy men evaluated by transthoracic Doppler echocardiography. Int J Cardiol. 2008;129(2):193–7.CrossRef
6.
go back to reference Watt M, Essential oils. Their lack of skin absorption but effectiveness via inhalation. Aromatic Thymes. 1995;3(2):11–3. Watt M, Essential oils. Their lack of skin absorption but effectiveness via inhalation. Aromatic Thymes. 1995;3(2):11–3.
7.
go back to reference Yamada K, Mimaki Y, Sashida Y. Anticonvulsive effects of inhaling lavender oil vapour. Biol Pharm Bull. 1994;17(2):359–60.CrossRef Yamada K, Mimaki Y, Sashida Y. Anticonvulsive effects of inhaling lavender oil vapour. Biol Pharm Bull. 1994;17(2):359–60.CrossRef
8.
go back to reference Dalsgaard MK, Secher NH. The brain at work: a cerebral metabolic manifestation of central fatigue? J Neurosci Res. 2007;85:3334–9.CrossRef Dalsgaard MK, Secher NH. The brain at work: a cerebral metabolic manifestation of central fatigue? J Neurosci Res. 2007;85:3334–9.CrossRef
9.
go back to reference Chaudhuri A, Behan PO. Fatigue and basal ganglia. J Neurol Sc. 2000;179:34–42.CrossRef Chaudhuri A, Behan PO. Fatigue and basal ganglia. J Neurol Sc. 2000;179:34–42.CrossRef
10.
go back to reference Chaudhuri A, Behan PO. Fatigue in neurological disorders. Lancet. 2004;363:978–88.CrossRef Chaudhuri A, Behan PO. Fatigue in neurological disorders. Lancet. 2004;363:978–88.CrossRef
11.
go back to reference Harrington ME. Neurobiological studies of fatigue. Prog Neurobiol. 2012;99:93–105.CrossRef Harrington ME. Neurobiological studies of fatigue. Prog Neurobiol. 2012;99:93–105.CrossRef
12.
go back to reference Leavitt VM, De Luca J. Central Fatigue: Issues Related to Cognition, Mood and Behavior, and Psychiatric Diagnoses. PM R. 2010;2:332–7.CrossRef Leavitt VM, De Luca J. Central Fatigue: Issues Related to Cognition, Mood and Behavior, and Psychiatric Diagnoses. PM R. 2010;2:332–7.CrossRef
13.
go back to reference Eric A, Newsholme EB. Branched-Chain Amino Acids and Central Fatigue. J Nutr. 2006;136:274–6.CrossRef Eric A, Newsholme EB. Branched-Chain Amino Acids and Central Fatigue. J Nutr. 2006;136:274–6.CrossRef
14.
go back to reference Felger JC, Miller AH. Cytokine effects on the basal ganglia and dopamine function:the subcortical source of inflammatory malaise. Front Neuroendocrinol. 2012;33(3):315–27.CrossRef Felger JC, Miller AH. Cytokine effects on the basal ganglia and dopamine function:the subcortical source of inflammatory malaise. Front Neuroendocrinol. 2012;33(3):315–27.CrossRef
15.
go back to reference Grim PF. Relaxation therapies and neurosis: a central fatigue interpretation. Psychosomatics. 1972;13(6):363–70.CrossRef Grim PF. Relaxation therapies and neurosis: a central fatigue interpretation. Psychosomatics. 1972;13(6):363–70.CrossRef
16.
go back to reference Millet Y, Aubert D, Favier FB, et al. Effect of acute hypoxia on central fatigue during repeated isometricleg contractions. Scand J Med Sci Sports. 2009;19:695–702.CrossRef Millet Y, Aubert D, Favier FB, et al. Effect of acute hypoxia on central fatigue during repeated isometricleg contractions. Scand J Med Sci Sports. 2009;19:695–702.CrossRef
17.
go back to reference Perry N, Perry E. Aromatherapy in the management of psychiatric disorders: clinical and neuropharmacological perspectives. CNS Drugs. 2006;20(4):257–80.CrossRef Perry N, Perry E. Aromatherapy in the management of psychiatric disorders: clinical and neuropharmacological perspectives. CNS Drugs. 2006;20(4):257–80.CrossRef
18.
go back to reference Boehm K, Büssing A, Ostermann T. Aromatherapy as an adjuvant treatment in Cancer care — a descriptive systematic review. Afr J Tradit Complement Altern Med. 2012;9(4):503–18.PubMedPubMedCentral Boehm K, Büssing A, Ostermann T. Aromatherapy as an adjuvant treatment in Cancer care — a descriptive systematic review. Afr J Tradit Complement Altern Med. 2012;9(4):503–18.PubMedPubMedCentral
19.
go back to reference Varney E, Buckle J. Effect of inhaled essential oils on mental Exhaustionand moderate burnout: a small pilot study. J Altern Complement Med. 2013;19(1):69–71.CrossRef Varney E, Buckle J. Effect of inhaled essential oils on mental Exhaustionand moderate burnout: a small pilot study. J Altern Complement Med. 2013;19(1):69–71.CrossRef
20.
go back to reference Steflitsch W, Steiner D, Peinhaupt W, Riedler B, Smuc M, Diewald G. Health promotion through prevention of stress and burnout with essential oils for all professionals at the Otto Wagner Spital in Vienna. Forsch Komplementmed. 2015;22(3):185–94.PubMed Steflitsch W, Steiner D, Peinhaupt W, Riedler B, Smuc M, Diewald G. Health promotion through prevention of stress and burnout with essential oils for all professionals at the Otto Wagner Spital in Vienna. Forsch Komplementmed. 2015;22(3):185–94.PubMed
21.
go back to reference Corner J, Cawler N, Hildebrand S. An evaluation of the use of massage and essential oils on the wellbeing of cancer patients. Int J Palliat Nurs. 1995;1(2):67–73.CrossRef Corner J, Cawler N, Hildebrand S. An evaluation of the use of massage and essential oils on the wellbeing of cancer patients. Int J Palliat Nurs. 1995;1(2):67–73.CrossRef
22.
go back to reference Wilcock A, Manderson C, Weller R, Walker G, Carr D, Carey AM, Broadhurst D, Mew J, Ernst E. Does aromatherapy massage benefit patients with cancer attending a specialist palliative care day Centre? Palliat Med. 2004;18(4):287–90.CrossRef Wilcock A, Manderson C, Weller R, Walker G, Carr D, Carey AM, Broadhurst D, Mew J, Ernst E. Does aromatherapy massage benefit patients with cancer attending a specialist palliative care day Centre? Palliat Med. 2004;18(4):287–90.CrossRef
23.
go back to reference Graham PH, Browne L, Cox H, Graham J. Inhalation aromatherapy during radiotherapy: results of a placebo-controlled double-blind randomized trial. J Clin Oncol. 2003;21(12):2372–6.CrossRef Graham PH, Browne L, Cox H, Graham J. Inhalation aromatherapy during radiotherapy: results of a placebo-controlled double-blind randomized trial. J Clin Oncol. 2003;21(12):2372–6.CrossRef
24.
go back to reference Maddocks-Jennings W, Wilkinson JM, Cavanagh HM, Shillington D. Evaluating the effects of the essential oils Leptospermum scoparium (manuka) and Kunzea ericoides (kanuka) on radiotherapy induced mucositis: a randomized, placebo controlled feasibility study. Eur J Oncol Nurs. 2009;13(2):87–93.CrossRef Maddocks-Jennings W, Wilkinson JM, Cavanagh HM, Shillington D. Evaluating the effects of the essential oils Leptospermum scoparium (manuka) and Kunzea ericoides (kanuka) on radiotherapy induced mucositis: a randomized, placebo controlled feasibility study. Eur J Oncol Nurs. 2009;13(2):87–93.CrossRef
25.
go back to reference Yamashita M, Yamamoto T. Establishment of a rat model of central fatigue induced by chronic sleep disorder and excessive brain tryptophan. Japan J Cogn Neurosci. 2013;15:67–74. Yamashita M, Yamamoto T. Establishment of a rat model of central fatigue induced by chronic sleep disorder and excessive brain tryptophan. Japan J Cogn Neurosci. 2013;15:67–74.
26.
go back to reference Lillehei AS, Halcón LL, Savik K, Reis R. Effect of inhaled lavender and sleep hygiene on self-reported sleep issues: a randomized controlled trial. J Altern Complement Med. 2015;21(7):430–8.CrossRef Lillehei AS, Halcón LL, Savik K, Reis R. Effect of inhaled lavender and sleep hygiene on self-reported sleep issues: a randomized controlled trial. J Altern Complement Med. 2015;21(7):430–8.CrossRef
27.
go back to reference Yamashita M, Yamamoto T. Tryptophan and Kynurenic Acid May Produce an Amplified Effect in Central Fatigue Induced by Chronic Sleep Disorder. Int J Tryptophan Res. 2014;7:9–14.CrossRef Yamashita M, Yamamoto T. Tryptophan and Kynurenic Acid May Produce an Amplified Effect in Central Fatigue Induced by Chronic Sleep Disorder. Int J Tryptophan Res. 2014;7:9–14.CrossRef
28.
go back to reference Komiya M, Takeuchi T, Harada E. Lemon oil vapor causes an anti-stresseffect via modulating the 5-HT and DA activities in mice. Behav Brain Res. 2006;172:240–9.CrossRef Komiya M, Takeuchi T, Harada E. Lemon oil vapor causes an anti-stresseffect via modulating the 5-HT and DA activities in mice. Behav Brain Res. 2006;172:240–9.CrossRef
29.
go back to reference Umezu T. Evidence for dopamine involvement in ambulation promotedby pulegone in mice. Pharmacol Biochem Behav. 2010;94:497–502.CrossRef Umezu T. Evidence for dopamine involvement in ambulation promotedby pulegone in mice. Pharmacol Biochem Behav. 2010;94:497–502.CrossRef
30.
go back to reference Lehrner J, Marwinski G, Lehr S. Et cl. Ambient odors oforange and lavender reduce anxiety and improve mood in a dental office. Physiol Behav. 2005;86:92–5.CrossRef Lehrner J, Marwinski G, Lehr S. Et cl. Ambient odors oforange and lavender reduce anxiety and improve mood in a dental office. Physiol Behav. 2005;86:92–5.CrossRef
31.
go back to reference Luosheng H, Yanfei GU, Hong LI. Advances in herbal volatile oil and aromatic herbs. China J Chinese Material Medica. 2009;34(12):1605–10. Luosheng H, Yanfei GU, Hong LI. Advances in herbal volatile oil and aromatic herbs. China J Chinese Material Medica. 2009;34(12):1605–10.
32.
go back to reference National Pharmacopoeia Committee. Pharmacopoeia of People’s Republic of China. Beijing: China Medical Science Press; 2015. National Pharmacopoeia Committee. Pharmacopoeia of People’s Republic of China. Beijing: China Medical Science Press; 2015.
33.
go back to reference Wu Y, Zhang Y, Xie G, et al. The Metabolic Responses to Aerial Diffusion of Essential Oils. Plos One. 2012;7(9):e44830.CrossRef Wu Y, Zhang Y, Xie G, et al. The Metabolic Responses to Aerial Diffusion of Essential Oils. Plos One. 2012;7(9):e44830.CrossRef
34.
go back to reference Alhaider IA, Aleisa AM, Tran TT, Alkadhi KA. Sleep depriva-tion prevents stimulation-induced increases of levels of P-CREBand BDNF: protection by caffeine. Mol Cell Neurosci. 2011;46:742–51.CrossRef Alhaider IA, Aleisa AM, Tran TT, Alkadhi KA. Sleep depriva-tion prevents stimulation-induced increases of levels of P-CREBand BDNF: protection by caffeine. Mol Cell Neurosci. 2011;46:742–51.CrossRef
35.
go back to reference Grahnstedt S, Ursin R. Platform sleep deprivation affects deep slow wave sleep in addition to REM sleep. Behav Brain Res. 1985;18:233–9.CrossRef Grahnstedt S, Ursin R. Platform sleep deprivation affects deep slow wave sleep in addition to REM sleep. Behav Brain Res. 1985;18:233–9.CrossRef
37.
go back to reference Porsolt RD, Bertin A, Jalfre M. Behavioral despair in mice: a primary screening test for antidepressants. Arch Int Pharmacodyn Ther. 1977;229:327–36.PubMed Porsolt RD, Bertin A, Jalfre M. Behavioral despair in mice: a primary screening test for antidepressants. Arch Int Pharmacodyn Ther. 1977;229:327–36.PubMed
38.
go back to reference Prut L, Belzung C. The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review. Eur J Pharmacol. 2003;463:3–33.CrossRef Prut L, Belzung C. The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review. Eur J Pharmacol. 2003;463:3–33.CrossRef
39.
go back to reference Silva AP, Cerqueira GS, Nunes LC, de Freitas RM. Efects of an aqueous extract of Orbignya phalerata Mart onlocomotor activity and motor coordination in mice and as antioxidant in vitro. Pharmazie. 2012;67(3):260–3.PubMed Silva AP, Cerqueira GS, Nunes LC, de Freitas RM. Efects of an aqueous extract of Orbignya phalerata Mart onlocomotor activity and motor coordination in mice and as antioxidant in vitro. Pharmazie. 2012;67(3):260–3.PubMed
40.
go back to reference Pellow S, Chopin P, File SE, et al. Validation of open: closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J neurosci Methods. 1985;14:149–67.CrossRef Pellow S, Chopin P, File SE, et al. Validation of open: closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J neurosci Methods. 1985;14:149–67.CrossRef
41.
go back to reference Lister RG. The use of a plus-maze to measure anxiety in the mouse. Psychovharmacolozv. 1987;92:180–5. Lister RG. The use of a plus-maze to measure anxiety in the mouse. Psychovharmacolozv. 1987;92:180–5.
42.
go back to reference JuYudong Y, Lishanshan, et al. The beneficial effect and application of aromatic plant. Modern Agric Sci. 2015;1:125–7. JuYudong Y, Lishanshan, et al. The beneficial effect and application of aromatic plant. Modern Agric Sci. 2015;1:125–7.
43.
go back to reference Lis-Balchin M. Essential. Oils and ‘aromatherapy’: their modern role in healing. J R Soc Health. 1997;117:324–9.CrossRef Lis-Balchin M. Essential. Oils and ‘aromatherapy’: their modern role in healing. J R Soc Health. 1997;117:324–9.CrossRef
44.
go back to reference Mori K, Nagao H, Yoshihara Y. The olfactory bulb: coding and processing of odor molecule information. Science. 1999;286(22):711.CrossRef Mori K, Nagao H, Yoshihara Y. The olfactory bulb: coding and processing of odor molecule information. Science. 1999;286(22):711.CrossRef
45.
go back to reference Komiya M, Takeuchi T, Harada E. Lemon oil vapor causes an anti-stress effect via modulating the 5-HT and DA activities in mice. Behav Brain Res. 2006;172(2):240–9.CrossRef Komiya M, Takeuchi T, Harada E. Lemon oil vapor causes an anti-stress effect via modulating the 5-HT and DA activities in mice. Behav Brain Res. 2006;172(2):240–9.CrossRef
46.
go back to reference Haze S, Sakai K, Gozu Y. Effects of fragrance inhalation on sympathetic activity in normal adults. Jpn J Pharmacol. 2002;90(3):247–53.CrossRef Haze S, Sakai K, Gozu Y. Effects of fragrance inhalation on sympathetic activity in normal adults. Jpn J Pharmacol. 2002;90(3):247–53.CrossRef
47.
go back to reference Pultrini Ade M, Galindo LA, Costa M. Effects of the essential oil from Citrus aurantium L. in experimental anxiety models in mice. Life Sci. 2006;78(15):1720–5.CrossRef Pultrini Ade M, Galindo LA, Costa M. Effects of the essential oil from Citrus aurantium L. in experimental anxiety models in mice. Life Sci. 2006;78(15):1720–5.CrossRef
48.
go back to reference White PA. Modulatory effects of Mentha piperata on lung tumor incidence, genotoxicity, and oxidative stress in benzo [a]pyrene-treated Swiss albino mice. Environ Mol Mutagen. 2007;48(6):503.CrossRef White PA. Modulatory effects of Mentha piperata on lung tumor incidence, genotoxicity, and oxidative stress in benzo [a]pyrene-treated Swiss albino mice. Environ Mol Mutagen. 2007;48(6):503.CrossRef
49.
go back to reference Setzer WN. Essential oils and anxiolytic aromatherapy. Nat Prod Commun. 2009;4(9):1305–16.PubMed Setzer WN. Essential oils and anxiolytic aromatherapy. Nat Prod Commun. 2009;4(9):1305–16.PubMed
50.
go back to reference Misharina TA, Samusenko AL. Antioxidant properties of essential oils from lemon, grapefruit, coriander, clove, and their mixtures. Prikl Biokhim Mikrobiol. 2008;44(4):482–6.PubMed Misharina TA, Samusenko AL. Antioxidant properties of essential oils from lemon, grapefruit, coriander, clove, and their mixtures. Prikl Biokhim Mikrobiol. 2008;44(4):482–6.PubMed
51.
go back to reference Ping H, Houlin X, Fang J, et al. Effect of Benzoinum and Borneo Camphor in different proportion on the miceof cerebral ischemia,anoxia and blood-brain barrier. Pharmacology Clinics Chinese Materia Medica. 2013;29(5):75–8. Ping H, Houlin X, Fang J, et al. Effect of Benzoinum and Borneo Camphor in different proportion on the miceof cerebral ischemia,anoxia and blood-brain barrier. Pharmacology Clinics Chinese Materia Medica. 2013;29(5):75–8.
52.
go back to reference Abidov M, Crendal F, Grachev S. Et cl. Effect of extracts from Rhodiola rosea and Rhodiola crenulata (Crassulaceae) roots on ATP content in mitochondria of skeletal muscles. Bull Exp Biol Med. 2003;136(6):585–7.CrossRef Abidov M, Crendal F, Grachev S. Et cl. Effect of extracts from Rhodiola rosea and Rhodiola crenulata (Crassulaceae) roots on ATP content in mitochondria of skeletal muscles. Bull Exp Biol Med. 2003;136(6):585–7.CrossRef
53.
go back to reference Gramza-Michałowska A. Caffeine in tea Camellia sinensis--content, absorption, benefits and risks of consumption. J Nutr Health Aging. 2014;18(2):143–9.CrossRef Gramza-Michałowska A. Caffeine in tea Camellia sinensis--content, absorption, benefits and risks of consumption. J Nutr Health Aging. 2014;18(2):143–9.CrossRef
54.
go back to reference Zhu M, Zhu H, Tan N. Et cl. The effects of Acorus tatarinowii Schott on 5-HT concentrations, TPH2 and 5-HT1B expression in the dorsal raphe of exercised rats. J Ethnopharmacol. 2014;2(158):431–6.CrossRef Zhu M, Zhu H, Tan N. Et cl. The effects of Acorus tatarinowii Schott on 5-HT concentrations, TPH2 and 5-HT1B expression in the dorsal raphe of exercised rats. J Ethnopharmacol. 2014;2(158):431–6.CrossRef
55.
go back to reference Vaio CD, Graziani G, Gaspari A, et al. Essential oils content and antioxidant properties of peel ethanol extract in 18 lemon cultivars. Sci Hortic. 2010;126(1):50–5.CrossRef Vaio CD, Graziani G, Gaspari A, et al. Essential oils content and antioxidant properties of peel ethanol extract in 18 lemon cultivars. Sci Hortic. 2010;126(1):50–5.CrossRef
56.
go back to reference Mc Devitt RA, Hiroi R, Mackenzie SM, Robin NC, et al. Serotonin 1B autoreceptors originating in the caudal dorsal raphenucleus reduce expression of fear and depression-like behavior. Biol.Psychiatry. 2011;69:780–7.CrossRef Mc Devitt RA, Hiroi R, Mackenzie SM, Robin NC, et al. Serotonin 1B autoreceptors originating in the caudal dorsal raphenucleus reduce expression of fear and depression-like behavior. Biol.Psychiatry. 2011;69:780–7.CrossRef
57.
go back to reference Treit D, Fundytus M. Thigmotaxisas a test for anxiolytic activity in rats. Pharmacol Biochem Behav. 1989;31(4):959–62.CrossRef Treit D, Fundytus M. Thigmotaxisas a test for anxiolytic activity in rats. Pharmacol Biochem Behav. 1989;31(4):959–62.CrossRef
58.
go back to reference Chen W-Z, Liu S, Chen F-F, et al. Prevention of postoperative fatigue syndrome in rat model by Ginsenoside Rb1 via Down-regulation of inflammation along the NMDA receptor pathway in the hippocampus. Biol Pharm Bull. 2015;38:239–47.CrossRef Chen W-Z, Liu S, Chen F-F, et al. Prevention of postoperative fatigue syndrome in rat model by Ginsenoside Rb1 via Down-regulation of inflammation along the NMDA receptor pathway in the hippocampus. Biol Pharm Bull. 2015;38:239–47.CrossRef
59.
go back to reference Rodgers R, Johnson N. Factor analysis of spatiotemporal and ethological measures in the murine elevated plus-maze test of anxiety. Pharmacol Biochem Behav. 1995;52:297–303.CrossRef Rodgers R, Johnson N. Factor analysis of spatiotemporal and ethological measures in the murine elevated plus-maze test of anxiety. Pharmacol Biochem Behav. 1995;52:297–303.CrossRef
Metadata
Title
Beneficial effect of compound essential oil inhalation on central fatigue
Authors
Chenxia Han
Feng Li
Simin Tian
Yan Liu
Huai Xiao
Xiumei Wu
Weiyue Zhang
Wei Zhang
Meng Mao
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Complementary Medicine and Therapies / Issue 1/2018
Electronic ISSN: 2662-7671
DOI
https://doi.org/10.1186/s12906-018-2375-6

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